Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study

Hedman, J.; Kaprio, Jaakko; Poussa, Tuija; Nieminen, Markku M.

doi:10.1093/ije/28.4.717

Cited by 475 publications

(341 citation statements)

References 27 publications

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“…The prevalence of SNP in general population is considered to be around 4 % [1]. In cadaveric studies, this prevalence has been shown to be as high as 32 % [2].…”

Section: Introductionmentioning

confidence: 99%

Importance of CT Scan of Paranasal Sinuses in the Evaluation of the Anatomical Findings in Patients Suffering from Sinonasal Polyposis

Varshney

Biswas

et al. 2015

Indian J Otolaryngol Head Neck Surg

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Sinonasal polyps are benign lesions arising from nose and/or sinuses mucosa. Paranasal sinuses computed tomogram (CT) scan are important for functional endoscopic sinus surgery (FESS) as their information assist the surgeon in pre-operative planning. This study aimed to show importance of CT scan in evaluation of anatomical variations to prove a correlation with disease process and extent of disease in sinonasal polyposis patients. A study was done from Sept, 2010 to Sept, 2011 with 33 patients presenting with nasal polyps. All recruited patients, after thorough history, general examination and thorough ENT examination, were examined by nasal endoscopy and sinus CT scans. All scans were carried out using a 3 mm thickness in axial and coronal planes with sagittal reconstruction. An analysis was then carried out to see anatomical variations and disease extent in CT scans. Maxillary sinus was the most commonly and most severely affected sinus, while the sphenoid sinus was the least involved sinus. Ostiomeatal complex (OMC) was found to be blocked in 84.85 % cases. There were few anatomic variations (57.58 %) found as hypertrophied uncinate process (30.30 %), septal deviation (21.21 %), skull base type-2, Concha bullosa, Haller's cell, Paradoxical middle turbinate, Onodi cell, pneumatized crista galli and dehiscent skull base. Hyperdense and heterogeneous opacification in paranasal sinuses was seen in 12.12 % patients. Importance of CT scans is to know anatomical variations as etiology, fungal etiology, to know extent of polyposis and anatomical variations to prevent complications during FESS and Navigation sinus surgery.

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“…The prevalence of SNP in general population is considered to be around 4 % [1]. In cadaveric studies, this prevalence has been shown to be as high as 32 % [2].…”

Section: Introductionmentioning

confidence: 99%

Importance of CT Scan of Paranasal Sinuses in the Evaluation of the Anatomical Findings in Patients Suffering from Sinonasal Polyposis

Varshney

Biswas

et al. 2015

Indian J Otolaryngol Head Neck Surg

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“…The incidence of aspirin-intolerant syndrome is about 10% of the US population, with most NSAIDs showing some level of cross-reactivity [57,58]. COX-2 inhibitors also cross-react with aspirin with a much lower incidence and the order of crossreactivity appears to vary inversely with the [90].…”

Section: Pulmonarymentioning

confidence: 99%

5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

Burnett

Levy

2012

Adv Therapy

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“…Un estudio finlandés estudió la prevalencia de IA en cuatro mil trescientos adultos utilizando un cuestionario específico. En este estudio se describe una prevalencia general de 5,7%, mientras que la prevalencia de IA que se presenta con síntomas respiratorios fue de 1,2% 6 . La prevalencia de AIA en la población general es de aproximadamente 0,2%, pero en los pacientes con IA aumenta a 16,4% 3 .…”

Section: Epidemiologíaunclassified

Intolerancia a la aspirina en pacientes con poliposis nasal y asma bronquial

2009

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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RESUMENLa tríada de la aspirina, caracterizada por intolerancia a la aspirina, asma bronquial y poliposis nasal, fue descrita inicialmente por Widal en 1922. La prevalencia de intolerancia a la aspirina en la población general es de aproximadamente 6%, pero estudios han revelado que hasta 78% de los pacientes con poliposis nasal padecen la triada. La presentación clínica consiste en un patrón característico evolutivo de la aparición de los síntomas, presentándose en primer lugar rinitis, luego poliposis nasal, asma bronquial y finalmente IA. Si bien es sabido que esta patología corresponde a una pseudoalergia, donde ocurre una degranulación inespecífica de los mastocitos, los mecanismos fisiopatológicos que gatillan esta degranulación no están totalmente dilucidados, siendo la hipótesis más aceptada actualmente aquella que guarda relación con las modificaciones en el metabolismo del ácido araquidónico causadas por la aspirina. Actualmente no existen exámenes de laboratorio para la confirmación diagnóstica de intolerancia a la aspirina, por lo que frente a la sospecha clínica de esta patología debe someterse al paciente a pruebas de provocación para hacer el diagnóstico certero de esta enfermedad, siendo la más utilizada la prueba de provocación con aspirina oral.Palabras clave: Intolerancia a la aspirina, poliposis nasal, triada de la aspirina. ABSTRACTThe aspirin triad, characterized by aspirin intolerance, bronchial asthma and nasal polyposis was first described by Widal in 1922. Prevalence of aspirin intolerance in the general population is near 6%, but studies have shown that 78% of the patients with nasal polyps suffer from the triad. Clinical presentation consists of a characteristic evolutive pattern, with rhinitis appearing first, then nasal polyps, bronchial asthma and finally aspirin intolerance. Even though it is well known that this pathology corresponds to pseudoallergy, where unspecific mast cell degranulation occurs, the physiopathologic mechanisms that trigger this degranulation are not completely understood. The most accepted hypothesis involves aspirin-induced modifications in the metabolism of arachidonic acid. Currently there are no in vitro tests available for aspirin intolerance 1 Médico, Tesista de magíster en Ciencias Médicas, Mención Inmunología, Universidad de Chile.

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Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study

Abstract: The current prevalence of doctor-diagnosed asthma among adults is 4.4%, and allergic rhinitis, nasal polyposis and aspirin intolerance are associated with an increased risk of asthma. There is also association between aspirin-induced asthma and allergic-like rhinitis.

Cited by 475 publications

References 27 publications

Importance of CT Scan of Paranasal Sinuses in the Evaluation of the Anatomical Findings in Patients Suffering from Sinonasal Polyposis

Importance of CT Scan of Paranasal Sinuses in the Evaluation of the Anatomical Findings in Patients Suffering from Sinonasal Polyposis

5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

Intolerancia a la aspirina en pacientes con poliposis nasal y asma bronquial

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