Prevalence of Asthma and Allergic Rhinitis in Children with Celiac Disease

Ozdogan, Sebnem; Urgancı, Nafiye; Usta, Merve; Kızılkan, Nuray Uslu

doi:10.5812/ijp.6358

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…It has been shown that atopy is found in coeliac patients, but it is still unclear whether this coexistence is to be considered coincidental or an expression of a real association. Several case-control studies (23,24) failed to demonstrate an increased prevalence of atopic conditions in children with CD when compared to controls. On the other hand, Kero et al (25) reported a cumulative incidence of asthma in children with CD (24.6%) significantly higher than in children without CD (3.4%; P<0.001) and Ress et al (26) showed that CD prevalence in children with active atopic dermatitis was more than four times as high as in randomly selected children.…”

Section: Discussionmentioning

confidence: 99%

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Oliveira¹,

Mohan

Fagbemi

2018

Arq. Gastroenterol.

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Section: Discussionmentioning

confidence: 99%

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Oliveira¹,

Mohan

Fagbemi

2018

Arq. Gastroenterol.

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“…In our study, no relationship was discovered between diet coherence and olfactory functions and nasal cells. 30…”

Section: Discussionmentioning

confidence: 99%

Does Celiac Disease Affect Smell Sensation, Mucociliary Clearance and Nasal Smear?

BERKİTEN,

TUTAR,

GÖKDEN

et al. 2024

KBB ve BBC Dergisi

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We aimed to evaluate olfactory function and nasal smear cytology in patients with celiac disease (CD) and healthy volunteers. Material and Methods: In this study, a total 74 subjects including 38 CD patients and 36 healthy controls were involved. CD has been verified by serological tests and small intestine biopsy. Sniffin Stick test was used to evaluate olfactory function. Nasal mucociliary clearance (MCC) time was measured with saccharin test. Neutrophils, eosinophils, basophilic and goblet cells were evauluted in nasal cytology. Sniffin test findings, MCC, nasal cytology and response to treatment with diet findings of CD patients and control group have been compared. Results: In CD group, normosmia was detected in 20 patients, and hiposmia in 17 patients. Total smell score (TDI) was 35±4 in control group, while it was 31±8 in CD group. The difference between two groups was statistically significant (p=0.009). While there was no statistically significant difference between the groups in terms of discrimination (DIS) and identification (ID) scores (p=0.277; p=0.960), the mean theroshold (THR) was found to be statistically significantly lower in the CD group (p=0.018). No evident difference has been determined between the two groups in terms of nasal MCC duration (p=0.948). While there was no statistically signicant difference in the average goblet cell grade, eosinophil, neutrophil, and lymphocyte grade average differences were significant (p=0.001). There was no statistically remarkable difference between diet compliant and non-diet compliant group in terms of THR, DIS, ID, and TDI scores (p>0.05). Conclusion: In our study, deterioration of nasal functions and nasal cytological findings-in particularly lymphocyte infiltration-makes it possible to think that CD group is a systemic disease that affects all organs, especially mucous membranes.

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“…Although the exact causes of concomitance are unknown but their common prevalence have surely been discussed in the recent years. [19][20][21][22] A study from Switzerland 21 having large number of cases with CD as well controls found an increased hazard ratio of asthma as 1.61 (95% CI: 1.50-1.72) for cases with CD. Incidence of hospitalization was significantly raised in cases having CD and asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Common genetic as well as environmental factors have been argued to be the causes of CD along with asthma. Kero and colleagues 22 showed that the risk of asthma was 7.26 times increased in cases who had been diagnosed with CD. Zauli and coworkers 24 found a positive association of CD with atopy and noted that an overall prevalence of 1% amongst atopic cases in Italy.…”

Section: Discussionmentioning

confidence: 99%

“…As CD is described as autoimmune disease, also linked with T helper type 1 and type 2 cells, these are said to play the dominant role in pathophysiology of diseases like asthma as well other allergic disorders. [19][20][21][22] While no work finding out the possible association of CD with asthma or any allergic disorder is done in Pakistan, few international studies are there but with inconsistent findings. Some suggested that allergic disorders may occur with autoimmune diseases as both have some common risk factors of genetic and environmental origin.…”

Section: Introductionmentioning

confidence: 99%

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Asthma and Allergic Rhinitis amongst children having Celiac disease.

Khuhro¹,

Rehman²,

Waqas³

et al. 2019

TPMJ

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Objectives: Relationship amongst celiac disease (CD) and lung diseases has been discussed in the past. Studies have documented that CD is linked with lung diseases. CD has also been described to complement asthma. This study was planned to document the prevalence of asthma as well as allergic rhinitis in confirmed cases of CD and conducted pulmonary function testing in children aged 5 to 16 years while comparing them with controls. Study Design: Cross sectional study. Setting: Department of Pediatrics Medicine, Children Hospital Chandka Medical College / Shaheed Mohtarma Benazir Bhutto Medical University, Larkana. Period: From 1st January 2018 to 30th June 2018. Material & Methods: We enrolled 50 confirmed cases of CD along with 100 controls with non specific abdominal pain. All were aged 6 to 16 years, of both genders. Demographics as well as questions related to asthma and allergic rhinitis were noted. Results: Amongst a total of 150 children, 61 (40.7%) male and 89 (59.3%) female. Overall mean age amongst children was 9.80 years with standard deviation of 2.6 years. A total of 40 (26.7%) children who had weight below the 3rd percentile while 36 (24.0%) had height below the 3rd percentile. Most children, 82 (54.7%) had normal BMI. Weight below the 3rd percentile and height below the 3rd percentile were of statistical significance as children with a weight and height below the 3rd percentile were significantly higher in the CD group (P = 0.026 and P = 0.005, respectively). Asthma and allergic rhinitis characteristics were not much different between the two groups (p > 0.05). The Pulmonary function test (PFT) results showed that 7 (14.0%) cases with CD and 12 (12.0%) controls had obstructive pulmonary changes (p > 0.05). Conclusion: Rates of Asthma and allergic rhinitis in children having CD were not significantly higher in comparison to controls. No linkage between asthma and allergic rhinitis symptoms was seen children having CD.

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Prevalence of Asthma and Allergic Rhinitis in Children with Celiac Disease

Abstract: Background: Celiac disease is an autoimmune disorder characterized by damage to the small intestinal mucosa following the intake of glutencontaining foods in genetically predisposed individuals. Studies suggest that celiac disease is associated with asthma and allergic rhinitis.

Cited by 3 publications

References 31 publications

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Does Celiac Disease Affect Smell Sensation, Mucociliary Clearance and Nasal Smear?

Asthma and Allergic Rhinitis amongst children having Celiac disease.

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