Prevalence of articular chondrocalcinosis in elderly subjects in a rural area of Catalonia.

Sanmartí, Raimón; Pañella, Daniel Raventós; Brancós, M A; Canela, Jaume; Collado, Antonia Espinosa; Brugués, Joan Mora

doi:10.1136/ard.52.6.418

Cited by 55 publications

(25 citation statements)

References 10 publications

(1 reference statement)

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“…Of note in this study was that we had a high proportion of female patients. However, our population is similar to other studies of CPDD in terms of age and gender distribution [21,22]. Also, the prevalence of CPDD in our patient cohort was 12%, which is comparable to the 15% in an elderly cohort reported by Wilkins [23] and the 14% reported by Doherty [24].…”

Section: Discussionsupporting

confidence: 76%

Osteoarthritis of the Scaphoidtrapezium Joint: an Early Sign of Calcium Pyrophosphate Dihydrate Disease

Peter

Simmen²,

Brühlmann³

et al. 2001

Clin Rheumatol

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The aim of this study was to determine the value of scaphoidtrapezium osteoarthritis (ST osteoarthritis) as an early sign of calcium pyrophosphate dihydrate disease (CPDD) in a cohort of patients undergoing surgery for osteoarthritis of the first carpometacarpal joint. We examined whether patients with cartilage calcification of the wrist at the time of operation had ST osteoarthritis, indicating CPDD at an earlier time (retrospective study), and whether patients with ST osteoarthritis but without cartilage calcification at the time of surgery develop radiological or clinical signs of CPDD at a later time (prospective study). From 1 January 1989 to 31 December 1995 a total of 169 patients (from an orthopaedic clinic) with a diagnosis of osteoarthritis of the first carpometacarpal joint were included in the study; 167 underwent surgery and two were treated without. Of the 16 patients showing calcification on surgery and therefore included in the retrospective study, 12 had prior radiographs, of which eight showed ST osteoarthritis. Among these, four had no concomitant cartilage calcification in the prior radiographs. Of the 32 patients in the prospective group having ST osteoarthritis but no calcifications at the time of surgery, 27 could be clinically examined. Of these, two showed cartilage calcifications on the follow-up radiographs of the hands. The presence of ST osteoarthritis is a helpful diagnostic finding for the diagnosis of CPDD, especially in cases without radiographic cartilage or fibrocartilage calcification of the wrist. ST osteoarthritis may then point to the correct diagnosis.

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Section: Discussionsupporting

confidence: 76%

Osteoarthritis of the Scaphoidtrapezium Joint: an Early Sign of Calcium Pyrophosphate Dihydrate Disease

Peter

Simmen²,

Brühlmann³

et al. 2001

Clin Rheumatol

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“…The high frequency of patients with unilateral knee involvement in the OA + CPPD group of our study seems also to corroborate the predisposing role of OA in local CPPD deposition. The high frequency (25%) of CPPD crystal deposition in our series of patients with knee OA supports the idea that there is some causal relationship between both conditions; indeed, the prevalence of CPPD crystal deposition of the knee in the general population of the same age without OA is much lower (10%-15%) [1,6,7,22,23]. The question whether obesity could play a role in CPPD crystal deposition was addressed.…”

Section: Discussionmentioning

confidence: 54%

“…Predisposing factors such as a previously damaged joint [1,2], and metabolic diseases such as hypothyroidism [3] or haemochromatosis [4], have been described for both diseases. Although intra-articular calcium pyrophosphate dihydrate (CPPD) crystal deposition can be observed in advanced stages of OA [5][6][7], the occurrence of these crystal deposits during the evolution of OA has not yet been specifically evaluated.…”

Section: Introductionmentioning

confidence: 99%

Local Deposition of Calcium Pyrophosphate Crystals in Evolution of Knee Osteoarthritis

L¹,

Linthoudt²,

Gerster

2001

Clin Rheumatol

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The aim of the study was to investigate the frequency of development of local calcium pyrophosphate (CPPD) crystal deposition in patients with knee OA initially found negative for these crystals, as well as to discover whether prognostic indicators for this subset of patients can be found. A clinical follow-up of records of outpatients with idiopathic knee OA was established. An anteroposterior plain radiography of the knee joints was made initially and at the end of the observation period. The follow-up period needed to be more than 1 year. Patients were divided into two groups. The first included patients with knee OA who did not develop intra-articular CPPD crystal deposition during the observation period (OA group). The second included those patients whose X-rays or synovial fluid (SF) analysis in the follow-up showed these crystal deposits to be present (OA + CPPD group). There were 59 patients (42 women, 17 men) who met the selection criteria. During the observation period (8.1 + 7.4 years in the OA group, 10.4 +/- 6 years in the OA + CPPD group), intra-articular CPPD deposits were observed in 15 patients (25%): 10 on the X-rays, eight in the SF and three in both examinations. Age at diagnosis of OA and incidence of obesity were similar in both groups. There was a trend (P = 0.21) towards men developing intra-articular CPPD crystal deposits more frequently than women. OA in only one knee joint was significantly more frequent in the group with CPPD (P<0.01). Of those with CPPD deposits 40% required surgery at the end of the observation period, compared to 27.2% of those without deposits (P = 0.27). The waiting period before knee surgery was shorter in the OA + CPPD group but the difference was not statistically significant. In conclusion, local CPPD crystal deposition was observed in 25% of cases during the evolution of knee OA. No predictive factors were found. OA of the knee could, per se, favour the development of CPPD deposits. The occurrence of intra-articular CPPD deposits seemed to be related to a more rapid and severe evolution of OA of the knee.

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“…Although studies have been performed on the epidemiology of CPPD crystal deposition, they have focused on articular cartilage in the extremitieswith radiographic determination of calcium deposition as a diagnostic criterion (4,7,8). In the literature to date, there has been a focus on associated complications such as inflammation (the socalled "crowned dens" syndrome, which is predominantly due to CPPD but also hydroxyapatite crystals) (9)(10)(11)(12)(13)(14), mass effect causing compression on the cervicomedullary junction (15,16), or an association with odontoid fractures (17).…”

Section: Image Acquisition and Analysismentioning

confidence: 99%

Frequency of Atlantoaxial Calcium Pyrophosphate Dihydrate Deposition at CT

Chang

Lim²,

Wolfson³

et al. 2013

Radiology

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Prevalence of articular chondrocalcinosis in elderly subjects in a rural area of Catalonia.

Cited by 55 publications

References 10 publications

Osteoarthritis of the Scaphoidtrapezium Joint: an Early Sign of Calcium Pyrophosphate Dihydrate Disease

Osteoarthritis of the Scaphoidtrapezium Joint: an Early Sign of Calcium Pyrophosphate Dihydrate Disease

Local Deposition of Calcium Pyrophosphate Crystals in Evolution of Knee Osteoarthritis

Frequency of Atlantoaxial Calcium Pyrophosphate Dihydrate Deposition at CT

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