Prevalence of Arthritis Among Adults with Prediabetes and Arthritis-Specific Barriers to Important Interventions for Prediabetes — United States, 2009–2016

Sandoval-Rosario, Michelle; Nayeri, Babak Michael; Nmd,; Rascon, Addey; Boring, Michael A.; Aseret-Manygoats, Teresa; Helmick, Charles G.; Hootman, Jennifer; Imperatore, Giuseppina; Barbour, Kamil E.

doi:10.15585/mmwr.mm6744a4

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…In one study, the prevalence of physical inactivity and obesity among US adults with prediabetes and arthritis was found to be 56.5 and 50.1%, respectively, higher than that in adults without prediabetes and arthritis. 20) Physical inactivity is reportedly associated with the risk of progression to chronic diseases including obesity, prediabetes, T2DM, coronary heart disease, and RA. 15,21,28) Conversely, physical activity reduces proinflammatory markers by IL-6 production, hence inhibiting chronic disease development.…”

Section: Discussionmentioning

confidence: 99%

“…21) Because activity-induced improvement in insulin activity (decreased rapidly) is dependent on the duration and intensity of previous activity, adults should participate in aerobic activity at least 3 days/ week with no more than 2 consecutive days without activity. 20,31) As the prevalence and incidence of diabetes increase worldwide, 32) regular physical activity could play an important role in the reduction of the risk of developing of T2DM and RA in prediabetic adults. 33) Additionally, US adults with metabolic syndromes are reportedly associated with a 2-fold risk of developing T2DM and CVD.…”

Section: Discussionmentioning

confidence: 99%

“…Joint pain, joint stiffness and deformity reduced the engagement of patients with RA in physical activity. 17,20) 56.5% of adults with both RA and prediabetes are physically inactive. 20) According to a study by the Diabetes Prevention Program (DPP), physical activity and weight loss interventions can reduce the risk of diabetes by 58%.…”

mentioning

confidence: 99%

“…17,20) 56.5% of adults with both RA and prediabetes are physically inactive. 20) According to a study by the Diabetes Prevention Program (DPP), physical activity and weight loss interventions can reduce the risk of diabetes by 58%. [21][22][23] Physical activity and glycemic control may be beneficial in the inhibition of RA progression as well as in the reduction of its prevalence in patients with prediabetes.…”

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confidence: 99%

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Physical Activity and Prevalence of Rheumatoid Arthritis in Korean Adults with Prediabetes in the 2009-2013 National Health Cohort Study

Sin

2019

Korean J Clin Pharm

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Prevalence of rheumatoid arthritis (RA) in patients with type2 diabetes mellitus (T2DM) and prediabetes was known to be higher than that of general population, 1-5) further increasing its risk for disease prevalence among adults with advanced age, 6-7) long disease duration, 6-7) and poor glycemic control. 1-2) RA is an autoimmune disease that causes chronic inflammation in the area surrounding musculoskeletal or synovial joints and connective tissues. 1-3,7-8) T2DM is significantly associated with bone, cartilage, ligament, and tendon damage. 2-3) RA development results from a multifactorial interaction of genes and the environment, including the abnormal response of anti-citrullinated protein antibodies (ACPAs) to antigens. These interactions result in synovial inflammation, bone, cartilage, and tissue damage, composed of pro-inflammatory cytokines. 4-5,8-9) Pro-inflammatory cytokines 5,9) such as interferongamma (IFN-γ), interleukin (IL)-1ß, IL-2, IL-5, IL-7, IL-8, and TNF-α, granulocyte macrophage-colony stimulating factor (GM-CSF), are also known to be high in overweight patients with prediabetes. [4][5]9) With biological pharmacotherapies, modifiable behavior such as physical activity has been shown to induce the antiinflammatory myokine IL-6, 10) which induces the release of ABSTRACT Background: Rheumatoid arthritis is highly prevalent in overweight patients with type 2 diabetes mellitus and can be reduced by physical activity via altered proinflammatory parameters. However, the association between the frequency of physical activity and the prevalence of rheumatoid arthritis in prediabetic patients remains unclear and was evaluated in this study. Methods: Utilizing the Korean National Health Insurance Sharing Service database, 58,391 adults, who met the research criteria and underwent a general medical check-up between 2009 and 2013, were selected for this study. To analyze the data, a logistic regression with a proc survey logistic procedure was used. Results: The study revealed that the cumulative rheumatoid arthritis prevalence was lower in prediabetic patients compared to that in the control group (OR, 0.64; 95% CI, 0.483-0.840; p=0.001). More frequent physical activity (>3 days/week) was significantly associated with a reduced rheumatoid arthritis prevalence in both groups (OR, 0.28; 95% CI, 0.039-0.521; p=0.044 vs. OR, 0.15; 95% CI, 0.063-0.237; p=0.007). Additionally, a 3.8-fold higher risk of rheumatoid arthritis development was observed in prediabetic adults with less frequent baseline physical activity (≤2 days/week). Overall, in prediabetes, the prevalence of rheumatoid arthritis was associated with the frequency of physical activity and not with the fasting plasma glucose levels. Conclusion: More frequent physical activity is associated with a low risk of developing rheumatoid arthritis in prediabetic patients. Thus, further studies are needed to confirm the clinical outcomes of frequent physical activity in rheumatoid arthritis prevention and control.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Physical Activity and Prevalence of Rheumatoid Arthritis in Korean Adults with Prediabetes in the 2009-2013 National Health Cohort Study

Sin

2019

Korean J Clin Pharm

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“…При экстраполяции на более чем 45 миллионов взрослых в США в возрасте 20 лет с предиабетом, у 42,7% была недостаточная ФА. Доказано, что рекомендации по ФА для людей с низкой активностью и другими ограничениями необходимо индивидуализировать в рамках специальной программы упражнений, чтобы учесть их конкретные ограничения [66,67]. Однако, вмешательства в образ жизни, протестированные в клинических испытаниях, были плохо реализованы в условиях первичной медицинской помощи из-за растущего числа людей, живущих с предиабетом и ограниченными инфраструктурой, ресурсами и координацией усилий по профилактике диабета [68].…”

Section: подходы к лечениюunclassified

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

Пырикова

Осипова

Полякова

2020

Arhivʺ vnutrennej mediciny

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Prediabetes is a common violation of carbohydrate metabolism, the medical and social relevance of which is due to the negative impact on the incidence of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). The analyzed literature emphasizes the presence of a close pathogenetic relationship between type 2 DM/prediabetes and CVD. This relationship becomes even more relevant, taking into account, on the one hand, the persistent upward trend in the prevalence of carbohydrate metabolism disorders in the population, and on the other hand, the fact that in patients with dysglycemia it is cardiovascular complications that are the main cause of death. However, while the significance of type 2 DM as a risk factor for CVD is widely known and its presence immediately stratifies most patients to a group of high or very high cardiovascular risk, the contribution of prediabetes to the development of CVD remains underestimated among the therapeutic and cardiological communities. The high prevalence of prediabetes creates prerequisites for a further increase in the incidence of type 2 DM and CVD in the Russian Federation, which requires doctors of various specialties to be wary of early detection of prediabetes, since timely preventive measures can significantly reduce the risk of type 2 DM and its complications in the future. Currently, the effectiveness of both non-drug and drug strategies in preventing the development of type 2 DM in people with prediabetes has been confirmed, more and more data are accumulating about the possibility of effective prevention of CVD in prediabetes. According to modern research, the primary role of measures to actively change lifestyle in the treatment and prevention of prediabetes is emphasized, at the same time, the effectiveness of these measures can be reduced due to insufficient commitment of the patients themselves to their independent long-term implementation. Therefore, the strategy of prescribing metformin for the prevention of type 2 diabetes is absolutely justified if the doctor and patient recognize the inefficiency or inability to follow the recommendations for active lifestyle changes for a long time. The article presents the data on the etiology, epidemiology, diagnosis, and approaches to the management of patients with prediabetes from the standpoint of modern recommendations.

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Genetic underpinning of the comorbidity between type 2 diabetes and osteoarthritis

Arruda

Hartley

Katsoula

et al. 2023

The American Journal of Human Genetics

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Prevalence of Arthritis Among Adults with Prediabetes and Arthritis-Specific Barriers to Important Interventions for Prediabetes — United States, 2009–2016

Cited by 9 publications

References 8 publications

Physical Activity and Prevalence of Rheumatoid Arthritis in Korean Adults with Prediabetes in the 2009-2013 National Health Cohort Study

Physical Activity and Prevalence of Rheumatoid Arthritis in Korean Adults with Prediabetes in the 2009-2013 National Health Cohort Study

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

Genetic underpinning of the comorbidity between type 2 diabetes and osteoarthritis

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