Prevalence of ApoB100 rs693 gene polymorphism in metabolic syndrome among female students at King Abdulaziz University

Alghamdi, Rana A.; Al-Zahrani, Maryam H.; Balgoon, Maha J.; Alkhattabi, Nuha A.

doi:10.1016/j.sjbs.2021.02.064

Cited by 4 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there are no changes in amino acids, silent mutations of specific SNPs are attributable to increased cardiovascular risks [ 21 ]. For instance, an rs693 polymorphism has been reported to cause an altered lipid profile [ 16 , 21 , 22 ]. The SNP rs693 is located on the most extended exon of the APOB gene, with 7572 base pairs [ 17 ].…”

Section: The Role Of Cholesterol-related Genes In Dyslipidemiamentioning

confidence: 99%

“…Alghamdi et al (2021) reported a significant association between the rs693 AG genotype and TC levels and the rs693 GG genotype and TG levels in a young female group with MetS compared to controls; however, there was no significant association in other genotypes (AA/AG/GG) and lipid parameters, including LDL, HDL and Apo B100 levels, between the MetS and control groups [ 22 ]. Similarly, a case-control study involving patients with acute coronary syndrome and healthy controls found no correlation between SNP rs693 polymorphisms and apolipoprotein B levels [ 26 ].…”

Section: The Role Of Cholesterol-related Genes In Dyslipidemiamentioning

confidence: 99%

See 1 more Smart Citation

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

et al. 2022

View full text Add to dashboard Cite

Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessive nutrients and sedentary lifestyle are modifiable and could be improved by lifestyle modification. However, genetic susceptibility to MetS, a non-modifiable factor, has attracted the attention of researchers, which could act as the basis for future diagnosis, prognosis, and therapy for MetS. Several cholesterol-related genes associated with each characteristic of MetS have been identified, such as apolipoprotein, lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and adiponectin. This review aims to summarize the genetic information of cholesterol-related genes in MetS, which may potentially serve as biomarkers for early prevention and management of MetS.

show abstract

Section: The Role Of Cholesterol-related Genes In Dyslipidemiamentioning

confidence: 99%

Section: The Role Of Cholesterol-related Genes In Dyslipidemiamentioning

confidence: 99%

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

et al. 2022

View full text Add to dashboard Cite

show abstract

Association of Apelin gene rs3115757 variation and expression with metabolic syndrome among female students in King Abdulaziz University

et al. 2021

View full text Add to dashboard Cite

Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome

et al. 2023

View full text Add to dashboard Cite

Atherogenic dyslipidemia plays a critical role in the development of metabolic syndrome (MetS), being one of its major components, along with central obesity, insulin resistance, and hypertension. In recent years, the development of molecular genetics techniques and extended analysis at the genome or exome level has led to important progress in the identification of genetic factors (heritability) involved in lipid metabolism disorders associated with MetS. In this review, we have proposed to present the current knowledge related to the genetic etiology of atherogenic dyslipidemia, but also possible challenges for future studies. Data from the literature provided by candidate gene-based association studies or extended studies, such as genome-wide association studies (GWAS) and whole exome sequencing (WES,) have revealed that atherogenic dyslipidemia presents a marked genetic heterogeneity (monogenic or complex, multifactorial). Despite sustained efforts, many of the genetic factors still remain unidentified (missing heritability). In the future, the identification of new genes and the molecular mechanisms by which they intervene in lipid disorders will allow the development of innovative therapies that act on specific targets. In addition, the use of polygenic risk scores (PRS) or specific biomarkers to identify individuals at increased risk of atherogenic dyslipidemia and/or other components of MetS will allow effective preventive measures and personalized therapy.

show abstract

Prevalence of ApoB100 rs693 gene polymorphism in metabolic syndrome among female students at King Abdulaziz University

Cited by 4 publications

References 32 publications

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Association of Apelin gene rs3115757 variation and expression with metabolic syndrome among female students in King Abdulaziz University

Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome

Contact Info

Product

Resources

About