Prevalence of anxiety disorders in epilepsy

Wiglusz, Mariusz S.; Landowski, Jerzy; Cubała, Wiesław Jerzy

doi:10.1016/j.yebeh.2017.11.025

Cited by 35 publications

(32 citation statements)

References 17 publications

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“…In line with some of the previous studies, this finding confirms that enhanced emotional behavior and anxiety might be one relevant factor that can contribute to the burden of the kindling paradigm depending on the experimental conditions. Moreover, this result is in line with an increased prevalence of anxiety disorders in patients with epilepsy . Of interest, a recent study reported a correlation between seizure frequency and anxiety levels in patients .…”

Section: Discussionsupporting

confidence: 74%

“…Moreover, this result is in line with an increased prevalence of anxiety disorders in patients with epilepsy. 25,26 Of interest, a recent study reported a correlation between seizure frequency and anxiety levels in patients. 27 Thus our data during kindling progression seem to reflect the respective psychiatric comorbidity in patients with uncontrolled seizure activity.…”

Section: Discussionmentioning

confidence: 99%

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Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

et al. 2018

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

et al. 2018

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“…This indicator of anxiety was also found by Lamberty et al in the heterozygous SV2A mice (+/-) [29]. Indeed, the existence of anxiety and mood disorders has been reported not only in animal models of epilepsy [67,68], but also in patients [69–73]. Additionally, it was found a possible influence of the sex in the anxiety level displayed by the different genotypes (interaction Sex × Genotype ), with significant group differences in males, but not in females.…”

Section: Discussionsupporting

confidence: 68%

Anxiety-like features and spatial memory problems as a consequence of hippocampal SV2A expression

et al. 2019

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The Synaptic Vesicle Protein 2A (SV2A) is a transmembrane protein whose presence is reduced both in animal models and in patients with chronic epilepsy. Besides its implication in the epileptic process, the behavioural consequences of the changes in its expression remain unclear. The purpose of our research is to better understand the possible role(s) of this protein through the phenotype of cKO ( Grik4 Cre+/- , SV2A lox/lox ) mice, male and female, which present a specific decrease of SV2A expression levels in the hippocampal glutamatergic neurons but without any epileptic seizures. In this study, we compare the cKO mice with cHZ ( Grik4 Cre+/- , SV2A lox/+ ) and WT ( Grik4 Cre+/+ , SV2A lox/lox ) mice through a battery of tests, used to evaluate different features: the anxiety-related features (Elevated Plus Maze), the locomotor activity (Activity Chambers), the contextual fear-related memory (Contextual Fear Conditioning), and the spatial memory (Barnes Maze). Our results showed statistically significant differences in the habituation to a new environment, an increase in the anxiety levels and spatial memory deficit in the cHZ and cKO groups, compared to the WT group. No statistically significant differences due to the genotype appeared in the spontaneous locomotor activity or the fear-linked memory. However, sexual differences were observed in this last feature. These results highlight not only an important role of the SV2A protein in the cognitive and anxiety problems typically encountered in epileptic patients, but also a possible role in the symptomatology of other neurodegenerative diseases, such as the Alzheimer’s disease.

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“…Panic disorder is common in epilepsy, and in 1 recent study was observed in 13.5% of PWE (Wiglusz et al, 2018). There are few studies on panic disorder in epilepsy, possibly because of the difficulty in distinguishing between panic disorder and epilepsy in PWE that suffer panic attacks as symptoms of seizures (Scalise et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

Depressive Symptom Severity in Individuals With Epilepsy and Recent Health Complications

Kumar

Lhatoo²,

Liu³

et al. 2019

J Nerv Ment Dis

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Identifying relationships between depression severity and clinical factors may help with appropriate recognition and management of neuropsychiatric conditions in persons with epilepsy (PWE). Demographic characteristics, epilepsy variables, and medical and psychiatric comorbidities were examined from a baseline RCT sample of 120 PWE. Among demographic characteristics, only inability to work was significantly associated with depression severity (p=0.05). Higher 30-day seizure frequency (p <0.01) and lower quality of life (p<0.

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Prevalence of anxiety disorders in epilepsy

Cited by 35 publications

References 17 publications

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

Anxiety-like features and spatial memory problems as a consequence of hippocampal SV2A expression

Depressive Symptom Severity in Individuals With Epilepsy and Recent Health Complications

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