Prevalence of Anticardiolipin Antibodies in Pregnancies with History of Repeated Miscarriages~!2010-03-24~!2010-06-11~!2010-08-26~!

Spegiorin, Lígia Cosentino Junqueira Franco; Galão, Eloisa Aparecida; Bagarelli, Lúcia Buchalla; Oliani, António Hélio; Godoy, José María Pereira de

doi:10.2174/1874312901004010028

Cited by 9 publications

(10 citation statements)

References 22 publications

(25 reference statements)

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“…The prevalence is lower than that observed by other authors [15,16]. The prevalance of LA was thrice that of ACA and this observation was in contrast to other studies [6,30]. This variation is attributed to difference in sensitivity of various ELISA kits used, lack of standardization and difference in normal cut off levels (range 2 SD to 5 SD) for ACA.…”

Section: Discussioncontrasting

confidence: 66%

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Lupus Anticoagulants and Anticardiolipin Antibodies in Indian Women with Spontaneous, Recurrent Fetal Loss

Rawat

Sikka

Rusia

et al. 2014

Indian J Hematol Blood Transfus

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Spontaneous and recurrent pregnancy loss are common complications of pregnancy resulting from varied causes including antiphospholipid syndrome (APS). Treatment of women with APS increases the chance of a subsequent successful pregnancy. The study aimed to find the prevalence of lupus anticoagulants (LA) and anticardiolipin antibodies (ACAs) in women with spontaneous/ recurrent fetal loss and compare with women with normal obstetric history. Hundred women with spontaneous/ recurrent fetal loss and 50 healthy pregnant controls were tested for LA by complete blood counts, Prothrombin time, Activated partial thromboplastin time (APTT), LA sensitive APTT and dilute Russell viper venom time (dRVVT) (screening and confirmatory) and ACAs (ELISA). LA was detected in 15 % patients using dRVVT confirmatory test and ACA in 5 %, all controls being negative. Twenty one % patients were detected by LA sensitive APTT (sensitivity 92.9 %, specificity 100 %) and 100 % with dRVVT screening test (sensitivity 98.8 %, specificity 100 %). We recommend that screening for antiphospholipid antibodies must be done in women with spontaneous/recurrent foetal loss even in the absence of other clinical manifestations using a combination of tests.

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Section: Discussioncontrasting

confidence: 66%

“…Diagnosis of APS includes laboratory testing for antiphospholipid antibodies. Of the antiphospholipid antibodies, the most important are Lupus anticoagulant (LA) and anticardiolipin antibodies (ACAs) [6].…”

Section: Introductionmentioning

confidence: 99%

Lupus Anticoagulants and Anticardiolipin Antibodies in Indian Women with Spontaneous, Recurrent Fetal Loss

Rawat

Sikka

Rusia

et al. 2014

Indian J Hematol Blood Transfus

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“…There is evidence that they affect approximately 10% of cases of RSA [7,8,12]. These antibodies are specific to phospholipids expressed on the cell membrane and contribute to early fetal loss, potentially acting in reducing trophoblastic implantation [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, maternal thromboembolism when present can exert strong influence on the success of pregnancy obscuring the importance of aCL [22,23]. Previous observations reported a higher frequency of aCL in women with a history of RSA [12,23]. There are reports highlighting the importance of aCL in reproductive success in which they account for approximately 10% of cases of RSA [4,8].…”

Section: Discussionmentioning

confidence: 99%

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Anticorpos anticardiolipina e abortos espontâneos recorrentes em mulheres brasileiras

Santana

Spegiorin²,

Ferreira

et al. 2015

Sci Med

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Aims:To determine the frequency of anti-cardiolipin antibodies (aCL) in women with previous history of recurrent spontaneous abortion (RSA). Methods: Medical records from pregnant women seen from April 2005 to December 2008 at the High-Risk Pregnancy Unit at the Hospital de Base from FUNFARME (Fundação Faculdade Regional de Medicina), in São José do Rio Preto, São Paulo, Brazil, were revised. Patients older than 18 years who had at least two spontaneous abortions and who were tested for aCL were included in the study. Data on maternal age, number of miscarriages and the results of serological tests for aCL were recorded. The exact Fisher's test was used to compare the results. A p value less than 0.05 was considered significant. Results: During the study period a total of 294 pregnant women were seen, from whom 44 consecutive women fulfilled the inclusion criteria. The overall mean age was 33.8±5.4 years (range: 22 to 44; median: 34). Eighteen (40.9%) patients were reagent for aCL and 26 (59.1%) non-reagent, and the difference between their mean age was not statistically significant (reagent: 34.6±5.8 years; non reagent: 33.2±5.2 years, p=0.4001). Fourteen (77.8%) patients presented IgM aCL and six (33.2%), IgG aCL. Two patients (11%) were reagent for both IgM and IgG aCL. In the most of cases the aCL antibody titers were compatible with low risk for pregnancy morbidity. The number of abortions ranged from two to six. The average number of abortions among those reagent for aCL was 3.5±1.1 and in those non-reagent was 2.9±1.1 (p=0.0813). Conclusions:The frequency of aCL was elevated among patients with a history of RSA, especially those having higher number of fetal losses. Among women with at least two spontaneous abortions, the mean number of abortions was not significantly different between those reagent for aCL and those non reagent.

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Modulation of an aqueous extract of Chinese medicine prescription Anzi Heji (安子合剂) on ratio of CD4+CD25+FOXP3+ regulatory T cells in anticardiolipin antibody-positive patients with threatened abortion

Zhu

2016

Chin. J. Integr. Med.

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Prevalence of Anticardiolipin Antibodies in Pregnancies with History of Repeated Miscarriages~!2010-03-24~!2010-06-11~!2010-08-26~!

Cited by 9 publications

References 22 publications

Lupus Anticoagulants and Anticardiolipin Antibodies in Indian Women with Spontaneous, Recurrent Fetal Loss

Lupus Anticoagulants and Anticardiolipin Antibodies in Indian Women with Spontaneous, Recurrent Fetal Loss

Anticorpos anticardiolipina e abortos espontâneos recorrentes em mulheres brasileiras

Modulation of an aqueous extract of Chinese medicine prescription Anzi Heji (安子合剂) on ratio of CD4+CD25+FOXP3+ regulatory T cells in anticardiolipin antibody-positive patients with threatened abortion

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