Prevalence of antibody to human T lymphotropic virus type III by risk group and area, United Kingdom 1978-84.

Mortimer, Philip P.; Jesson, W.J.; Vandervelde, Elise M.; Pereira, M. S.

doi:10.1136/bmj.290.6476.1176

Cited by 41 publications

(10 citation statements)

References 14 publications

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“…6 Specimens giving positive results were tested by " capture" radioimmunoassay (RIA)7 and a commercial enzyme linked immunoasssay (Elavia, Pasteur Diagnostics) to confirm that they contained antibody to HTLV-III/LAV.…”

Section: Methodsmentioning

confidence: 99%

Sexual lifestyle and clinical findings related to HTLV-III/LAV status in homosexual men.

Evans¹,

Dawson²,

McLean³

et al. 1986

Sexually Transmitted Infections

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SUMMARY A study of 304 sexually active homosexual men, most of whom had multiple casual partners, showed that receptive anogenital intercourse, independent ofanal bleeding, was the only risk factor for HTLV-III/LAV transmission. There was no evidence that HTLV-III/LAV infection, measured by seropositivity, was transmitted by oroanal or orogenital routes, or that insertive penile intercourse constituted a risk. The strongest predictor of seropositivity proved to be homosexual activity for more than five years, which may lead to enhanced susceptibility to infection. Sexual exposure to European men seemed to be even more hazardous than sexual exposure to men from the United States of America, and emphasised the epidemiological importance of the promiscuous homosexual abroad. Skin complaints were the most common presenting symptoms in men with antibody to HTLV-III/LAV. Extrainguinal lymphadenopathy was the commonest sign, which was present in just under half of those who were seropositive. More than one quarter of seropositive patients had had sexual intercourse with a woman in the five years before being tested.

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Section: Methodsmentioning

confidence: 99%

Sexual lifestyle and clinical findings related to HTLV-III/LAV status in homosexual men.

Evans¹,

Dawson²,

McLean³

et al. 1986

Sexually Transmitted Infections

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“…Thereafter capture RIA (Parry, 1986) Among anti-HIV positive women an increasing incidence was seen in injecting drug abusers, those with African connections and those with many sexual partners or with a sexual partner himself at increased risk of HIV infection (Table 3). Twenty-five infants of HIV-infected mothers were found to be positive during the study period, 2 in 1985, 7 in 1986 and 16 in 1987 homosexuals, especially in London (Mortimer et al 1985;Cheinsong Popov et al 1984). Since then continuing testing for anti-HIV has confirmed that cases of AIDS and ARC are outnumbered by cases of less severe HIV related disease and by asymptomatic infection.…”

Section: Anti-hiv Assaysmentioning

confidence: 99%

“…Until mid-1985 competitive radioimmunoassay (RIA) and immunofluorescence (IF) assays were used (Mortimer et al 1985). Thereafter capture RIA (Parry, 1986) Among anti-HIV positive women an increasing incidence was seen in injecting drug abusers, those with African connections and those with many sexual partners or with a sexual partner himself at increased risk of HIV infection (Table 3).…”

Section: Anti-hiv Assaysmentioning

confidence: 99%

“…In 1984 the Virus Reference Laboratory did a retrospective anonymous study of those groups thought to be at increased risk of human immunodeficiency virus (HIV) infection (Mortimer et al 1985) and began diagnostic testing for antibody to HIV (anti-HIV). A computer database for test requests was set up and data from it for the years 1984-7 are presented and analysed here.…”

Section: Introductionmentioning

confidence: 99%

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HIV infection in England and Wales: a changing pattern

Taylor¹,

Mortimer²

1989

Epidemiol. Infect.

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SUMMARYOf 32 983 specimens from 307 sources in England and Wales tested in the Virus Reference Laboratory for anti -HIV between 1984 and 1987, 6491 (20%) were positive. Ninety-five per cent of the positive subjects were male and 44 % of them were from three London genito-urinary medicine clinics. In 1987 the numbers of newly diagnosed HIV infections decreased in homosexual men and haemophiliacs and increased in injecting drug abusers; 148/1199 (12%) of all the positive findings in 1987 were in females. Between 1984 and 1987 the proportion of anti-HIV positive individuals who were asymptomatic fell by nearly 10% and the proportion with AIDS/ARC rose by nearly 10%. Of the requests leading to positive results 1280 (20%) were recognized as duplicates of previous positive results, while for 34 % of the requests no clinical information was provided. These deficiencies in the data compromise HIV surveillance based on diagnostic testing, and supplementary bias-free data are needed.

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“…3 The persisting relatively low prevalence of hepatitis B infection in our at risk population whose methods of transmission are similar and infectivity higher than those for HTLV-HI provides some encouragement that the spread of HTLV-III related disease among provincial homosexual men may be much lower than that witnessed in London.…”

mentioning

confidence: 98%

Control of hepatitis B and human T lymphotrophic virus type III (HTLV-III) in homosexuals in Sheffield.

Kinghorn¹,

Monteiro²

1986

Sexually Transmitted Infections

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Prevalence of antibody to human T lymphotropic virus type III by risk group and area, United Kingdom 1978-84.

Abstract: Antibody to human T lymphotropic virus type 1I1 (anti-HTLV-III)

Cited by 41 publications

References 14 publications

Sexual lifestyle and clinical findings related to HTLV-III/LAV status in homosexual men.

Sexual lifestyle and clinical findings related to HTLV-III/LAV status in homosexual men.

HIV infection in England and Wales: a changing pattern

Control of hepatitis B and human T lymphotrophic virus type III (HTLV-III) in homosexuals in Sheffield.

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