Prevalence of antibody to hepatitis E virus among wild sika deer, Cervus nippon, in Japan

Matsuura, Yu; Suzuki, Masatsugu; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo; Yokoyama, Masahiro; Igota, Hiromasa; Yamauchi, Keiko; Ishida, Setsuko; Fukui, Daisuke; Bando, Gen; Kosuge, Masao; Tsunemitsu, Hiroshi; Koshimoto, Chihiro; Sakae, K.; Chikahira, Masatsugu; Ogawa, Shinpei; Miyamura, Tatsuo; Takeda, Naokazu; Li, T. C.

doi:10.1007/s00705-007-0965-6

Cited by 43 publications

(41 citation statements)

References 29 publications

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“…In Japan, the prevalence among deer seems to be generally low, and HEV RNA has never Yu et al (2007) been detected in deer samples from Japan in cross-sectional studies, only in the mentioned human-related case (Tei et al, 2003). In serological studies, only 2% of the Sika deer have been shown to be seropositive for HEV (Sonoda et al, 2004;Matsuura et al, 2007), whereas wild boar from the same areas had a 9% seroprevalence (Sonoda et al, 2004). In contrast, Tomiyama et al (2009) found a high HEV seroprevalence (35%) in wild Yezo-deer (C. nippon yezoensis) from Hokkaido, where human hepatitis E is most prevalent within Japan Tanabe et al, 2011).…”

Section: Cervidsmentioning

confidence: 88%

Hepatitis E in wild ungulates: A review

Boadella¹

2015

Small Ruminant Research

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Section: Cervidsmentioning

confidence: 88%

Hepatitis E in wild ungulates: A review

Boadella¹

2015

Small Ruminant Research

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“…Foodborne transmission was described in Japan in patients infected after consumption of undercooked pig liver or meat from wild boar or deer [27][28][29]. This route of infection may occur also in Europe since HEV has been detected in commercial pig liver sold in groceries and there is a high HEV seroprevalence in many pig herds [30,31].…”

Section: Ab094267mentioning

confidence: 99%

Endemic hepatitis E in two Nordic countries

et al. 2009

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Antibodies against hepatitis E virus (anti-HEV) were found in 248 Swedish and Danish patients between 1993 and 2007. Most patients were symptomatic and tested for anti-HEV due to travel abroad. Among patients with known country of infection, most were infected in Asia, mainly on the Indian subcontinent. However, 29 patients were infected in Europe, nine of these had HEV IgM and/or HEV RNA in serum. In sera from 65 of 141 tested patients HEV RNA could be detected, and 63 strains could be typed by limited sequencing within ORF2. HEV RNA was found in sera from 71% of the patients with HEV IgM and IgG and in 18% of the patients with only detectable HEV IgG. It was also found up to three weeks after the onset of disease in 67% of the patients with known date of onset. Patients infected in Europe were infected by genotype 3, and were older than those infected by genotype 1 (mean age 55.3 vs 30 years, p<0.001). Since it is known that genotype 3 can infect domestic pigs, HEV strains from 18 piglets in 17 herds in Sweden and Denmark were sequenced. Phylogenetic analyses of the genotype 3 strains showed geographical clades and high similarity between strains from patients and pigs from the same area. There are thus autochthonous hepatitis E cases in Scandinavia, and there are probably many undiagnosed ones. Patients with hepatitis of unknown etiology should therefore be investigated for anti-HEV even if they have not been outside Europe, since infections acquired from pigs or other animals should be taken into consideration.

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“…Studies on wild sika deer ( Cervus nippon ) have detected low prevalence rates for HEV, which suggests that sika deer are accidental hosts for the virus ( 4 , 5 ), despite the transmission link discovered between them and HEV in Japan ( 3 ) that raised awareness of the possibility that game animals transmit HEV ( 2 ). In Europe, information about HEV infection in wild ruminants is limited to reports suggesting that roe deer ( Capreolus capreolus ) and red deer ( Cervus elaphus ) can act as HEV hosts ( 6 – 8 ).…”

mentioning

confidence: 99%