Prevalence of antibiotic resistance genes from effluent of coastal aquaculture, South Korea

Jang, Hyun Min; Kim, Young Beom; Choi, Sangki; Lee, Yunho; Shin, Seung Gu; Unno, Tatsuya; Kim, Young Mo

doi:10.1016/j.envpol.2017.10.006

Cited by 137 publications

(55 citation statements)

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“…In addition to β-lactam resistance, a relatively high percentage of resistance to trimethoprim/sulfamethoxazole and tetracycline was also identified. This finding was consistent with previous studies that tetracycline and sulfonamide resistance genes were widely found in aquaculture environments [15,41]. Notably, most carbapenem-resistant strains were cross-resistant to other classes of clinically important antibiotics, including quinolones (ciprofloxacin) and aminoglycosides (gentamicin).…”

Section: Discussionsupporting

confidence: 92%

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

Zhang

Luo

et al. 2020

IJERPH

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Hospital sewage plays a key role in the dissemination of antibiotic-resistant genes (ARGs) by serving as an environmental antimicrobial resistance reservoir. In this study, we aimed to characterize the cephalosporin- and carbapenem-resistant isolates from hospital sewage and receiving rivers. The results showed that ESBL (blaCTX-M) and carbapenemase genes (blaNDM and blaKPC) were widely detected in a number of different bacterial species. These resistance genes were mainly harbored in Enterobacteriaceae, followed by Acinetobacter and Aeromonas isolates. More attention should be given to these bacteria as important vectors of ARGs in the environment. Furthermore, we showed that the multidrug resistance phenotype was highly prevalent, which was found in 85.5% Enterobacteriaceae and 75% Acinetobacter strains. Notably, the presence of carbapenemase genes in isolates from treated effluents and receiving rivers indicates that the discharges of wastewater treatment plants could be an important source for high-risk resistance genes propagation to the environment. In conclusion, this study shows a high prevalence of ESBL- and carbapenemase-producing bacteria in hospital sewage and receiving rivers in China. These findings have serious implications for human health, and also suggest the need for more efforts to control the dissemination of resistant bacteria from hospital sewage into the environment.

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Section: Discussionsupporting

confidence: 92%

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

Zhang

Luo

et al. 2020

IJERPH

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“…The ARGs of sul (sul1, sul2, sul3, sul/folP), tet (tetA, tetB, tetC, tetD), and qnr (qnrA, qnrB, qnrS, qnrD) were frequently detected at the coastal mariculture sites (Gao et al, 2018). Jang et al (2018) found tet (tetA, tetB, tetD, tetE, tetG, tetH, tetM, tetQ, tetX, tetZ, tetBP), sul (sul1, sul2), qnr (qnrS, qnrD), and erm (ermC) in the effluents of coastal mariculture in South Korea.…”

Section: Resultsmentioning

confidence: 99%

Proliferation of antibiotic resistance genes in coastal recirculating mariculture system

Wang

Lü

et al. 2019

Environmental Pollution

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a b s t r a c tThe abuse of antibiotics has caused the propagation of antibiotic resistance genes (ARGs) in aquaculture systems. Although the recirculating systems have been considered as a promising approach for preventing the coastal water pollution of antibiotics and ARG, rare information is available on the distribution and proliferation of ARGs in the recirculating mariculture system. This study firstly investigated the proliferation of ARGs in coastal recirculating mariculture systems. Ten subtypes of ARGs including tet (tetB, tetG, tetX), sul (sul1, sul2), qnr (qnrA, qnrB, qnrS), and erm (ermF, ermT) were detected. The absolute abundances of the ARGs detected in the mariculture farm were more than 1 Â 10 4 copies/mL. The sulfonamide resistance genes (sul1 and sul2) were the most abundant ARGs with the abundance of 3.5 Â 10 7 e6.5 Â 10 10 copies/mL. No obvious correlation existed between the antibiotics and ARGs. Some bacteria were positively correlated with two or more ARGs to indicate the occurrence of multidrug resistance. The fluidized-bed biofilter for wastewater treatment in the recirculating system was the main breeding ground for ARGs while the UV sterilization process could reduce the ARGs. The highest flux of ARGs (6.5 Â 10 21 copies/d) indicated that the discharge of feces and residual baits was the main gateway for ARGs in the recirculating mariculture system to enter the environments.

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“…Antimicrobial resistant (AMR) bacteria cause over 35,000 human deaths annually in the USA, 33,000 in the European Economic Area, 58,000 in India and probably more in SE Asia and these numbers are expected to rise 24,25 due to rapid socioeconomic development and population growth. Although the precise quantities of antimicrobials used in aquaculture are mostly unknown (especially in LMICs), antibiotic residues and AMR bacteria are often found in aquaculture environments [26][27][28] . Since aquatic environments are effective reservoirs of AMR bacteria from different sources 29 (e.g.…”

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confidence: 99%

Aquaculture at the crossroads of global warming and antimicrobial resistance

et al. 2020

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In many developing countries, aquaculture is key to ensuring food security for millions of people. It is thus important to measure the full implications of environmental changes on the sustainability of aquaculture. We conduct a double meta-analysis (460 articles) to explore how global warming and antimicrobial resistance (AMR) impact aquaculture. We calculate a Multi-Antibiotic Resistance index (MAR) of aquaculture-related bacteria (11,274 isolates) for 40 countries, of which mostly low-and middle-income countries present high AMR levels. Here we show that aquaculture MAR indices correlate with MAR indices from human clinical bacteria, temperature and countries' climate vulnerability. We also find that infected aquatic animals present higher mortalities at warmer temperatures. Countries most vulnerable to climate change will probably face the highest AMR risks, impacting human health beyond the aquaculture sector, highlighting the need for urgent action. Sustainable solutions to minimise antibiotic use and increase system resilience are therefore needed.

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Prevalence of antibiotic resistance genes from effluent of coastal aquaculture, South Korea

Cited by 137 publications

References 50 publications

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

Proliferation of antibiotic resistance genes in coastal recirculating mariculture system

Aquaculture at the crossroads of global warming and antimicrobial resistance

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