Prevalence of anti-R-13 antibodies in human<i>Trypanosoma cruzi</i>infection

Aznar, Christine; López-Bergami, Pablo; Brandariz, Silvia; Mariette, Christine; Liegeard, Pascale; Alves, Maria do Carmo de Deus; Barreiro, Erika Luna; Carrasco, Roxana; Lafon, Sonia; Kaplan, Dan; Miguez, Hortencia; Camacho, Clara; Levitus, Gabriela; Levin, James; Hontebeyrie, Mireille

doi:10.1111/j.1574-695x.1995.tb00197.x

Cited by 31 publications

(2 citation statements)

References 18 publications

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“…Chagas's chronic heart disease (cChHD) is a myocarditis characterized by arrhythmia, tachycardia and heart failure. In the chronic phase of the disease, patients present antibodies against the acidic rich C-terminal of Trypanosoma cruzi ribosomal P proteins [ 2 ]. It has been proposed that cChHD is an autoimmune disease produced by the existence of molecular mimicry between the C-terminal of ribosomal P proteins and the second extra cellular loop of the β1-adrenergic receptor ( H26R ) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruziribosomal P proteins and their interaction with a monoclonal antibody structural model

2009

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The acidic C-terminal peptides from Trypanosoma cruzi ribosomal P proteins are the major target of the antibody response in patients suffering Chagas chronic heart disease. It has been proposed that the disease is triggered by the cross-reaction of these antibodies with the second extra cellular loop of the 1-adrenoreceptor, brought about by the molecular mimicry between the acidic C-terminal peptides and the receptor's loop. To improve the understanding of the structural basis of the autoimmune response against heart receptors, the 3-dimensional structure of the C-terminal peptides of Trypanosoma cruzi ribosomal proteins P0 (EDDDDDFGMGALF) and P2 (EEEDDDMGFGLFD) were solved using the Electrostaticaly Driven MonteCarlo method. Their structures were compared with the second extra-cellular loop of our homology model of human rhodopsin and the existing experimental NMR structures of the C-terminal peptides from human P0 (EESDDDMGFGLFD) and from Leishmania braziliensis P0 (EEADDDMGFGLFD). Docking of Trypanosoma cruzi peptides P0, P2 and human rhodopsin loop into our anti-P2 monoclonal antibody homology model allowed to explore their interactions.The solution structure of peptides P0 and P2 can be briefly described as a bend. Although the global conformations of the peptides are not identical they shared a common region of four residues (3 to 6) that have a similar structure. The structural alignment of the five peptides also showed a surprising conformational similarity for the same residues. The antibody model and docking studies revealed a most remarkable feature in the active site, a positively charged, narrow and deep cavity where the acidic residues 3 to 6 were accommodated. These results suggest that the most important

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Section: Introductionmentioning

confidence: 99%

“…P013 (EDDDDDFGMGALF) and R13 (EEEDDDMGFGLFD) are the peptides corresponding to the last 13 amino acids of Trypanosoma cruzi P0 and P2β respectively and a major target of the humoral immune response against the parasite [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruziribosomal P proteins and their interaction with a monoclonal antibody structural model

2009

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Molecular Mimicry: Infection-Inducing Autoimmune Disease

Oldstone

2005

Current Topics in Microbiology and Immunology

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Anti-ribosomal-P antibodies in lupus nephritis, neuropsychiatric lupus, lupus hepatitis, and Chagas’ disease: promising yet limited in clinical utility

Abraham

Derk

2014

Rheumatol Int

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Anti-P antibodies have been associated with organ involvement in SLE, such as in autoimmune hepatitis, and have been suggested to be directly pathogenic. Neuropsychiatric lupus, lupoid hepatitis, autoimmune hepatitis, lupus nephritis, and Chagas' disease have been associated with the presence of anti-P antibody. This review seeks to look into the current literature on anti-P antibody and the association between SLE and non-SLE autoimmune connective tissue disorder.

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Prevalence of anti-R-13 antibodies in humanTrypanosoma cruziinfection

Cited by 31 publications

References 18 publications

Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruziribosomal P proteins and their interaction with a monoclonal antibody structural model

Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruziribosomal P proteins and their interaction with a monoclonal antibody structural model

Molecular Mimicry: Infection-Inducing Autoimmune Disease

Anti-ribosomal-P antibodies in lupus nephritis, neuropsychiatric lupus, lupus hepatitis, and Chagas’ disease: promising yet limited in clinical utility

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