Prevalence of Anterior Pituitary Dysfunction Twelve Months or More following Traumatic Brain Injury in Adults: A Systematic Review and Meta-Analysis

Emelifeonwu, John; Flower, Hannah; Loan, James J M; Andrews, Peter

doi:10.1089/neu.2018.6349

Cited by 31 publications

(21 citation statements)

References 74 publications

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“…Moreover, pediatric survivors of TBI show high incidence of health issues including pain, cardiovascular, and metabolic disorders (2). In particular, TBI precede the development of endocrinopathies, or dysfunction of the endocrine system, as reported in adults (7)(8)(9)(10)(11). Furthermore, both early and late endocrine changes can occur after TBI in pediatric patients (12).…”

Section: Introductionmentioning

confidence: 99%

“…In adults, the prevalence of endocrinopathy following TBI is common, with the most prevalent disorder being GH deficiency (7,10,14,15). A recent meta-analysis that included data from 2,756 adult TBI patients reported a 32% overall prevalence of at least one endocrine diagnosis after TBI (8). Similarly, a previous meta-analysis that included data of 1,203 adult TBI patients, reported a 27.8% overall prevalence of at least one endocrine dysfunction, with 6.2% of patients having more than one endocrine dysfunction post-TBI (16).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona

et al. 2020

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“…Future efforts with this model could be applied to other medical concerns that arise in patients with mild TBI. For example, our finding that the skull base substructures (such as pituitary gland) may be prone to injury could help clarify the biomechanics leading to neuroendocrine disorders reported after mild TBI (61)(62)(63).…”

Section: Discussionmentioning

confidence: 99%

The Biomechanics of Indirect Traumatic Optic Neuropathy Using a Computational Head Model With a Biofidelic Orbit

Singman

McCulley

et al. 2020

Front. Neurol.

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Indirect traumatic optic neuropathy (ITON) is an injury to the optic nerve due to head trauma and usually results in partial or complete loss of vision. In order to advance a mechanistic understanding of the injury to the optic nerve, we developed a head model with a biofidelic orbit. Head impacts were simulated under controlled conditions of impactor velocity. The locations of impact were varied to include frontal, lateral, and posterior parts of the head. Impact studies were conducted using two types of impactors that differed in their rigidity relative to the skull. The simulated results from both the impactors suggest that forehead impacts are those to which the optic nerve is most vulnerable. The mode and location of optic nerve injury is significantly different between the impacting conditions. Simulated results using a relatively rigid impactor (metal cylinder) suggest optic nerve injury initiates at the location of the intracranial end of the optic canal and spreads to the regions of the optic nerve in the vicinity of the optic canal. In this case, the deformation of the skull at the optic canal, resulting in deformation of the optic nerve, was the primary mode of injury. On the other hand, simulated results using a relatively compliant impactor (soccer ball) suggest that primary mode of injury comes from the brain tugging upon the optic nerve (from where it is affixed to the intracranial end of the optic canal) during coup countercoup motion of the brain. This study represents the first published effort to employ a biofidelic simulation of the full length of the optic nerve in which the orbit is integrated within the whole head.

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“…The studies by Devraj, Herndon and Gri n (17), MacLeod et al (40), Farin, Ullrich and Nagl (16), and Köppen et al (8) did not have a solely back pain population, but were included as the back pain population made up at least 10% of the overall study, which was pre-determined as the cut-off percentage for eligibility into this review. This cut off has been used as a marker for signi cance in other studies (57,58), but caution may be needed when interpreting the results of these studies.…”

Section: Strengths and Limitations Of This Reviewmentioning

confidence: 99%

Health Literacy and Health Outcomes in Patients with Back Pain – A Scoping Review

See

Smith

Car

et al. 2020

Preprint

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BACKGROUND: The World Health Organisation highlights back pain as a leading and growing cause of disability worldwide. In the field of chronic pain, higher health literacy is linked to lower pain intensity and better pain control. However, there remains a paucity of evidence, with a recent systematic review finding only three studies meeting its inclusion criteria. OBJECTIVES: This scoping review had two objectives in exploring research in chronic pain, which were to identify:1) The health literacy measures currently employed. 2) The back-pain health outcomes included in such work and the extent to which these reflect the core outcome set for clinical trials in non-specific low back pain.METHODS: The search broadened the search strategy used in the systematic review. It was conducted using thirteen bibliographic databases, employing medical subject heading (MeSH) terms for back pain and health literacy, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A thematic framework approach was used for analysis.RESULTS: The search yielded ten relevant studies for inclusion, amongst which a total of nine health literacy measures and 50 health outcome measures were used. The health outcomes assessed by the included studies could be broadly categorised into: Pain, Disability, Behaviour, Knowledge and Beliefs, and Resource Utilisation. Most outcome measures employed (36 out of 50) were not directly relevant to addressing the core outcome set for clinical trials in non-specific low back pain.CONCLUSIONS: A dearth of studies in this field of research was noted, especially in Asia and low-middle income countries. Methodological limitations were identified, including in study design and outcome measures. To allow for comparison across findings and the development of a rigorous evidence base, future work should include the core outcome set for clinical trials in non-specific low back pain. Furthermore, research thus far has focused on a narrow range of populations and there is an urgent need to broaden the evidence-base to include those with characteristics known to be moderators in health outcomes. Such work demands the incorporation of comprehensive measures of health literacy that have both generic and culturally sensitive components.

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Prevalence of Anterior Pituitary Dysfunction Twelve Months or More following Traumatic Brain Injury in Adults: A Systematic Review and Meta-Analysis

Cited by 31 publications

References 74 publications

Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona

Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona

The Biomechanics of Indirect Traumatic Optic Neuropathy Using a Computational Head Model With a Biofidelic Orbit

Health Literacy and Health Outcomes in Patients with Back Pain – A Scoping Review

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