Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®

Laffolie, Jan de; Laaß, Martin W.; Scholz, D; Zimmer, Klaus–Peter; Buderus, Stephan; Group, CHANGE Study Collaborators

doi:10.1155/2017/8424628

Cited by 10 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduced muscle mass[20] and anemia[21-23], both of which are frequently observed in patients with IBD, even when their disease is in remission, may also have affect fatigue, but so far, these factors have not been investigated in the adolescent IBD population.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in children and adolescents with inflammatory bowel disease

Vijver¹,

Gils²,

Beckers³

et al. 2019

WJG

View full text Add to dashboard Cite

AIMTo identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease (IBD).METHODSWe performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term “fatigue” or the related keywords “physical impairment” and “inflammatory bowel disease” with the filter “child” (age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.RESULTSWe identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn’s disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSIONFatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue.

show abstract

Section: Discussionmentioning

confidence: 99%

Fatigue in children and adolescents with inflammatory bowel disease

Vijver¹,

Gils²,

Beckers³

et al. 2019

WJG

View full text Add to dashboard Cite

show abstract

“…In addition to corticosteroid treatment and a low weight-for-age, our study identified anemia as a potential risk factor of B2 behavior, which has not been reported yet. Nevertheless, previous studies associated anemia with higher disease activity as well as lower self-assessed well-being supporting an impact of anemia on the development of a B2 behavior ( 24 ). Our study identified emesis as a risk factor and diarrhea as a protective factor of B2 behavior, which has not been reported yet.…”

Section: Discussionmentioning

confidence: 91%

Predicting complications in pediatric Crohn's disease patients followed in CEDATA-GPGE registry

Klamt

Laffolie²,

Wirthgen³

et al. 2023

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundComplications of Crohn's disease (CD) often impair patients' quality of life. It is necessary to predict and prevent these complications (surgery, stricturing [B2]/penetrating [B3] disease behavior, perianal disease, growth retardation and hospitalization). Our study investigated previously suggested and additional predictors by analyzing data of the CEDATA-GPGE registry.MethodsPediatric patients (< 18 years) diagnosed with CD with follow up data in the registry were included in the study. Potential risk factors for the selected complications were evaluated by performing Kaplan-Meier survival curves and cox regression models.ResultsFor the complication surgery, the potential risk factors older age, B3 disease, severe perianal disease and initial therapy with corticosteroids at the time of diagnosis were identified. Older age, initial therapy with corticosteroids, low weight-for-age, anemia and emesis predict B2 disease. Low weight-for-age and severe perianal disease were risk factors for B3 disease. Low weight-for-age, growth retardation, older age, nutritional therapy, and extraintestinal manifestations (EIM) of the skin were identified as risk factors for growth retardation during the disease course. High disease activity and treatment with biologicals were predictors for hospitalization. As risk factors for perianal disease, the factors male sex, corticosteroids, B3 disease, a positive family history and EIM of liver and skin were identified.ConclusionWe confirmed previously suggested predictors of CD course and identified new ones in one of the largest registries of pediatric CD patients. This may help to better stratify patients’ according to their individual risk profile and choose appropriate treatment strategies.

show abstract

“…The existing research in the pediatric population provides contradictory results regarding the prevalence of anemia among the different types of IBD. Previous studies found an association between disease type and prevalence of anemia, reporting a higher frequency in patients with CD than in patients with UC [16,19,20]. A possible explanation of this difference is that, in CD patients, more pathogenic mechanisms may play a role in the development of anemia, such as systemic inflammation, which is usually more severe in CD than in UC, Vitamin B12 malabsorption due to the terminal ileum involvement, and iron malabsorption due to the proximal gastrointestinal tract involvement.…”

Section: Discussionmentioning

confidence: 96%

Anemia in Newly Diagnosed Pediatric Patients with Inflammatory Bowel Disease

Shentova

Kofinova

Hadzhiyski

et al. 2021

Gastroenterology Insights

View full text Add to dashboard Cite

Anemia is the most common extraintestinal manifestation and complication of inflammatory bowel disease (IBD). The aim of our study was to assess the prevalence of anemia in newly diagnosed pediatric patients with IBD and to analyze its association with disease type, extent, and severity. We retrospectively reviewed the medical records of all patients with IBD treated in our department in the period of November 2011 to November 2020. The final analysis included the records of 80 children with newly diagnosed IBD: 45 with ulcerative colitis (UC) and 35 with Crohn’s disease (CD). The prevalence of anemia was 60.0% in the UC patients and 77.1% in the CD patients. Of the UC patients with anemia, 37.1% had pancolitis, 18.5% extensive disease, 33.3% left-sided colitis and 11.1% ulcerative proctitis. Of the CD patients with anemia, 81.5% had ileocolonic disease, 11.1% colonic disease and 7.4% ileal disease. Anemia was less common in patients with mild disease than in patients with moderate–severe disease (22.2 vs. 77.8%, p < 0.001 in UC and 25.9% vs. 74.1%, p < 0.001 in CD). Our study confirmed anemia as a frequent problem in pediatric patients with IBD. Children with more extensive and more severe disease are at higher risk to develop anemia.

show abstract

Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®

Cited by 10 publications

References 26 publications

Fatigue in children and adolescents with inflammatory bowel disease

Fatigue in children and adolescents with inflammatory bowel disease

Predicting complications in pediatric Crohn's disease patients followed in CEDATA-GPGE registry

Anemia in Newly Diagnosed Pediatric Patients with Inflammatory Bowel Disease

Contact Info

Product

Resources

About