Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

Sofue, Tadashi; Nakagawa, Naoki; Kanda, Eiichiro; Nagasu, Hajime; Matsushita, Kunihiro; Nangaku, Masaomi; Maruyama, Shoichi; Wada, Takashi; Terada, Yoshio; Yamagata, Kunihiro; Narita, Ichiei; Yanagita, Motoko; Sugiyama, Hitoshi; Sügimura, Takashi; Ito, Takafumi; Tamura, Kouichi; Isaka, Yoshitaka; Okada, Hirokazu; Tsuruya, Kazuhiko; Yokoyama, Hitoshi; Nakashima, Naoki; Kataoka, Hiromi; Ohe, Kazuhiko; Okada, Mihoko; Kashihara, Naoki

doi:10.1371/journal.pone.0236132

Cited by 70 publications

(67 citation statements)

References 35 publications

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“…The J-CKD-DB is a multicenter, automatically extracted comprehensive database of patients with CKD from 21 university hospitals in Japan (UMIN trial number, UMIN000026272) [23,24]. The inclusion criteria for the J-CKD-DB are as follows: 1) age �18 years; 2) proteinuria �1+ (dipstick test) and/or eGFR <60 ml/min/1.73 m 2 , where eGFR is calculated using the Japanese eGFR equation: eGFR (ml/min/1.73 m 2 ) = 194 × serum creatinine value -1.094 × age -0.287 (× 0.739 [for women]) [26].…”

Section: Study Setting and Participantsmentioning

confidence: 99%

“…In this study, we performed an observational cross-sectional investigation. To exclude most patients with acute kidney injury, we omitted inpatients from this analysis [24]. We identified 39,121 adult outpatients with at least one measurement of serum creatinine in seven university hospitals from January 1, 2014 to December 31, 2014.…”

Section: Study Setting and Participantsmentioning

confidence: 99%

“…We identified 39,121 adult outpatients with at least one measurement of serum creatinine in seven university hospitals from January 1, 2014 to December 31, 2014. We included 35,508 patients with CKD based on outpatient laboratory data that indicated eGFR of 5-60 ml/min/1.73 m 2 [24,28,29].…”

Section: Study Setting and Participantsmentioning

confidence: 99%

“…CKD G categories were defined as follows: stage G3a, eGFR of �45 and <60 ml/min/1.73 m 2 ; stage G3b, eGFR of �30 and <45 ml/min/1.73 m 2 ; stage 4, eGFR of �15 and <30 ml/min/ 1.73 m 2 ; and stage 5, eGFR <15 ml/min/1.73 m 2 [1,24]. eGFR5 categories were divided into 11 subgroups based on eGFR ranges of 5 ml/min/1.73 m 2 each, as performed in a previous study [24].…”

Section: Data Collectionmentioning

confidence: 99%

“…The Japan Chronic Kidney Disease Database (J-CKD-DB) is a large-scale, nationwide comprehensive clinical database of patients with CKD based on electronic health records data from participating university hospitals [23,24]. Using a standardized method for information exchange (Standardized Structured Medical Information eXchange; SS-MIX2) [25], the J-CKD-DB efficiently compiles clinical data of patients with CKD across hospitals, regardless of differences in electronic health records systems.…”

Section: Introductionmentioning

confidence: 99%

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Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

et al. 2020

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Section: Study Setting and Participantsmentioning

confidence: 99%

Section: Study Setting and Participantsmentioning

confidence: 99%

Section: Study Setting and Participantsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

et al. 2020

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Low cholesterol levels are good markers for central hypothyroidism in case with dialysis using roxadustat

Kita,

Okuyama,

Kondo

et al. 2024

Clinical Case Reports

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Key Clinical MessageRecently, hypoxia‐inducible factor prolyl hydroxylase (HIF‐PH) inhibitors have been used for renal anemia, but side effects have also been reported. We report on the association of central hypothyroidism and cholesterol with roxadustat. Based on this case and previous reports, we believe that patients receiving roxadustat should have their thyroid function and cholesterol levels checked regularly.

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Relationship between haemodynamic indicators and haemogram in patients with heart failure

Ogawa

Nagoshi

et al. 2022

ESC Heart Failure

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Aims Pulmonary congestion, reduced cardiac output, neurohumoral factor activation, and decreased renal function associated with decreased cardiac function may have various effects on haemograms. The relationship between these factors and haemograms in patients with heart failure has not been sufficiently investigated. Recently, it was suggested that the lungs are an important site for platelet (Plt) biosynthesis and that it is necessary to study the relationship between pulmonary congestion and Plt count in heart failure in detail. In this study, we examined the relationship between various haemodynamic indicators and haemograms in detail using statistical analyses. Methods and results A total of 345 patients who underwent cardiac catheterization for the evaluation of cardiac function between 1 January 2015 and 31 December 2020 were included in the study. Haemodynamic indices, including left ventricular end‐diastolic pressure (LVEDP) and cardiac index (CI), were measured. Plasma noradrenaline (Nor) concentration, estimated glomerular filtration rate (eGFR), white blood cell (WBC) count, haemoglobin (Hb) level, and Plt count were measured using blood samples collected at the same time. Structural equation modelling (SEM) was used to examine the relationship between LVEDP, CI, plasma Nor concentration, eGFR, WBC count, Hb level, and Plt count. Bayesian inference using SEM was performed for Plt count. A total of 345 patients (mean age: 66.0 ± 13.2 years) were included in this study, and 251 (73%) patients were men. After simple and multiple regression analyses, path diagrams were drawn and analysed using SEM. LVEDP showed a significant negative relationship with Plt count (standardized estimate: −0.129, P = 0.015), and CI showed a significant negative relationship with Hb level (standardized estimate: −0.263, P < 0.001). Plasma Nor concentration showed a significant positive relationship with WBC count (standardized estimate: 0.165, P = 0.003) and Plt count (standardized estimate: 0.198, P < 0.001). The eGFR had a significant positive relationship with Hb level (standardized estimate: 0.274, P < 0.001). Bayesian inference using SEM revealed no relationship between LVEDP and Hb level or WBC count but a significant negative relationship between LVEDP and Plt count. Conclusions LVEDP, CI, plasma Nor concentration, and eGFR were related to WBC count, Hb level, and Plt count in patients with heart failure. There was a strong relationship between elevated LVEDP and decreased Plt count, suggesting that pressure overload on the lungs may interfere with the function of the lung as a site of Plt biosynthesis.

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Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

Cited by 70 publications

References 35 publications

Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

Low cholesterol levels are good markers for central hypothyroidism in case with dialysis using roxadustat

Relationship between haemodynamic indicators and haemogram in patients with heart failure

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