Prevalence of and risk factors for Barrett's esophagus with intestinal predominant mucin phenotype

Amano, Yuji; Kushiyama, Yoshinori; Yuki, Takafumi; Takahashi, Yoshiko; Moriyama, Ichiro; Fukuhara, Hiroshi; Ishimura, Norihisa; Furuta, K.; Ishihara, Shunji; Adachi, Kyoichi; Maruyama, Riruke; Kinoshita, Yoshikazu

doi:10.1080/00365520500535485

Cited by 42 publications

(59 citation statements)

References 40 publications

(19 reference statements)

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“…In Japan, long-segment BE defined by a circumferential length of 3 cm or more is a considerably rare condition, with a reported prevalence as low as 0.2-0.6% [36,37]. In spite of this obstacle, we were able to successfully enroll substantial numbers of unequivocal patients with BE longer than 2 cm, many of whom had BE longer than 3 cm, by conducting a multicenter study comprising 10 general hospitals.…”

Section: Discussionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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Background: We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

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Section: Discussionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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“…Antibodies against human gastric mucin (HGM) (Novocastra, Newcastle, UK) and MUC2 (Santa Cruz Biotechnology, Santa Cruz, CA, USA) were used for phenotyping of Barrett's esophagus, as previously described. 23 When Barrett's epithelial cells were more dominantly stained by the anti-MUC2 antibody, the case was diagnosed as Barrett's esophagus with intestinal predominant mucin phenotype.…”

Section: Histopathologymentioning

confidence: 99%

Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus

Tamagawa

Ishimura

Uno

et al. 2012

Laboratory Investigation

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“…First, the number of patients with LSBE was small and they were studied retrospectively. LSBE is less prevalent in the Japanese population compared to other groups; investigators have reported that the prevalence of LSBE in Japan is 0.2%-0.5% (9,10,24). Therefore, a prospective Japanese multicenter study with a larger number of LSBE patients is needed.…”

Section: Discussionmentioning

confidence: 99%

“…Kyphosis mainly develops from osteoporosis-related wedging and/or the collapse of vertebral bodies, and is frequently found in the Japanese elderly. Kyphosis has been reported to be a risk factor for the presence of esophageal hiatal hernia (5,6) which is a strong risk factor for Barrett's esophagus (7)(8)(9)(10). Thus, kyphosis may have some association with Barrett's esopha- gus and might be used as a clinical sign of the presence of Barrett's esophagus and its associated cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Kyphosis and Barrett's Esophagus in Japanese Patients

et al. 2011

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Background Kyphosis is a risk factor for the presence of hiatal hernia, which is a strong predictor of Barrett's esophagus. However, the association between kyphosis and Barrett's esophagus has not yet been clarified. To investigate this relationship, the Cobb angle, a marker of kyphosis, was measured in patients with and without Barrett's esophagus. Methods From January 2006 to December 2010, 26 patients with long-segment Barrett's esophagus (LSBE) were retrospectively enrolled. As the comparative groups, 100 consecutive patients with shortsegment Barrett's esophagus (SSBE) and 100 consecutive control patients without Barrett's esophagus were also enrolled in this study. Cobb angles were measured on lateral chest radiographs, and kyphosis was defined as a Cobb angle of greater than 50°. Kyphosis, along with other patient characteristics, were evaluated as possible predictors for SSBE and LSBE. Results The mean Cobb angles in the non-BE, SSBE, and LSBE groups were 31.6°(95% CIs, 29.3°-33.9°), 34.8°(32.1°-37.4°) and 49.4°(44.9°-53.9°), respectively. Statistically significant differences were found between the LSBE and the other 2 groups (p<0.001). The mean Cobb angles were 33.3°±12.4°and 37.0°±14.1°, respectively in patients without and with hiatal hernia (p=0.039). Predictors for Barrett's esophagus of any length were erosive esophagitis and hiatal hernia. Kyphosis had the highest odds ratio for the presence of LSBE (OR, 1.50; 95% CI, 1.05-1.94; p=0.033). Other predictors were hiatal hernia and the absence of Helicobacter pylori infection. Conclusion Kyphosis is a risk factor for the presence of LSBE in Japanese patients.

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Prevalence of and risk factors for Barrett's esophagus with intestinal predominant mucin phenotype

Cited by 42 publications

References 40 publications

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus

Relationship between Kyphosis and Barrett's Esophagus in Japanese Patients

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