Prevalence of and Risk Factors for Oral Human Papillomavirus Among Young Women in Costa Rica

Kuhs, Krystle A. Lang; González, Paula; Struijk, Linda; Castro, Felipe A.; Hildesheim, Allan; Doorn, Leen–Jan van; Rodríguez, Ana Cecilia; Schiffman, Mark; Quint, Wim; Lowy, Douglas R.; Porras, Carolina; DelVecchio, Corey; Katki, Hormuzd A.; Jiménez, Silvia; Safaeian, Mahboobeh; Schiller, John T.; Solomon, Diane; Wacholder, Sholom; Herrero, Rolando; Kreimer, Aimée R.; Alfaro, Mario; Bratti, M. Concepción; Cortés, Bernal; Espinoza, Albert; Estrada, Yenory; Guillén, Diego Miguel Gracia; Morales, Jorge; Villegas, Luis Fernando Botero; Morera, Lidia Ana; Macklin, Nora; Sherman, Mark E.; Freer, Enrique; Bonilla, José; Garcı́a-Piñeres, Alfonso; Silva, Sandra; Atmella, Ivannia; Ramírez, Margarita; Pinto, Lígia A.; Kemp, Troy J.; Eklund, Claire; Hutchinson, Martha L.; Sidawy, Mary K.

doi:10.1093/infdis/jit369

Cited by 48 publications

(61 citation statements)

References 36 publications

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“…This is in contrast with the recent report of a significant association between β-HPV detection and HPVs 16/18 infections at the anal canal among HIV-negative men who have sex with men (24). Similarly, in one study, detection of α-HPVs in the oral cavity significantly increased the odds of β-HPV detection (25). …”

Section: Discussionmentioning

confidence: 89%

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Sichero

El‐Zein

Nunes

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Alpha-human papillomavirus (α-HPV) play a causal role in cervical cancer but little is known about the epidemiology of genital Beta-HPV infection. Methods We used Luminex and polymerase chain reaction (PCR) hybridization to detect β- and α-HPVs prevalence at enrolment and 12-months follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiological correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytological abnormalities. Results Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P=0.034). β-HPVs were mostly transient, however, only 1.98% women retained their original positivity at 12 months, whereas, persistence was higher for α-HPVs (5.15%) (P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiological correlates for β-HPV infections. Conclusions Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role the lack of epidemiological correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.

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Section: Discussionmentioning

confidence: 89%

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Sichero

El‐Zein

Nunes

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Oral sex has been reported to increase the risk of HPV infection among young men (18 - 24 years) and young women (mean age 21.9 years) [12, 13, 54]. On the other hand, other studies did not find a significant association between that and HPV infection in men or women [20, 22, 23]. These conflicting results may be attributed to the characteristics of the study participants (i.e., sexual activity, sexual behavior, and genital HPV infection status of sexual partner).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Shigeishi

Sugiyama

2016

J Clin Med Res

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BackgroundOral human papillomavirus (HPV) infection is associated with oral cancer development. However, few epidemiologic investigations have focused on oral HPV prevalence in healthy individuals. The objective of this study was to provide updated information regarding oral HPV prevalence in patients without oral cancer worldwide.MethodsWe systematically reviewed 29 studies reporting the prevalence of oral HPV infection that included 22,756 subjects (10,124 males, 12,623 females, and nine unknown gender; age range 2 - 89 years) and were published from January 2012 to June 2015.ResultsThe prevalence of overall HPV, low-risk type HPV, high-risk type HPV, and HPV16 in the reported cases was 5.5%, 2.2%, 2.7%, and 1.0%, respectively. The prevalence of overall HPV was considerably higher in males who had sex with males (12.2%) as compared to heterosexual males (4.7%) and females (2.9%). A meta-analysis was performed to elucidate significant risk factors for oral HPV infection, which revealed a significant statistical association for oral sex and smoking with oral HPV infection (odds ratio (OR): 1.90, 95% confidence interval (CI): 1.51 - 2.39, P < 0.0001; OR: 2.13, 95% CI: 1.32 - 3.43, P = 0.002).ConclusionsOur findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.

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“…A meta-analysis including studies of healthy subjects prior to 2009 observed a lower prevalence estimate of oral HPV infection (4.5%, 182 of 4070) [40]. HPV16, which causes the overwhelming majority of HPV-OSCCs in the USA [22,23], is the most common oncogenic oral HPV infection detected [39,40,41], with a prevalence of 1–1.3% [39,40]. …”

Section: Introductionmentioning

confidence: 99%

“…In non-HIV-infected adults, these behaviors include: lifetime and recent number of oral sex partners [50–52,56], recent number of rimming partners [50] and lifetime number of any sexual partners [39,52] and vaginal sex partners [41,52]. Oral HPV infection has also been associated with surrogates for increased sexual exposure, including history of anogenital warts [42,51] and HSV-2 seropositivity [53].…”

Section: Introductionmentioning

confidence: 99%

The role of sexual behavior in head and neck cancer: implications for prevention and therapy

Rettig

Kiess

Fakhry

2014

Expert Review of Anticancer Therapy

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HPV-positive oropharyngeal squamous cell carcinoma (HPV-OSCC) is associated with oral sexual behaviors. The sharp rise in incidence of HPV-OSCC in the USA has been attributed to changes in sexual norms over the past five decades, with lower age at sexual debut and higher numbers of sexual partners per individual. In addition, variations in HPV-OSCC prevalence by race, age cohort and gender may be attributable to differences in oral sexual behaviors among these groups. Oral HPV infection is the putative precursor to HPV-OSCC. Risk factors for oral HPV incidence, prevalence, clearance and persistence are crucial to understanding how, and in whom, oral HPV infection progresses to malignancy. Future investigation should focus on elucidating the natural history of oral HPV infection persistence and malignant transformation, developing effective screening tools and exploring opportunities for prevention such as vaccination and public health education.

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Prevalence of and Risk Factors for Oral Human Papillomavirus Among Young Women in Costa Rica

Abstract: Unlike cutaneous HPV types, alpha mucosal HPV types were uncommon in the oral region and were predominately associated with sexual behavior. Clinical Trials Registration. NCT00128661.

Cited by 48 publications

References 36 publications

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

The role of sexual behavior in head and neck cancer: implications for prevention and therapy

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