Prevalence of and Clinical Factors Associated with Lipoatrophy in HIV-Infected Koreans Receiving Highly Active Antiretroviral Therapy

Han, Sang Hoon; Chin, Bum Sik; Choi, Hee Kyoung; Shin, So Youn; Chae, Yun Tae; Baek, Ji-Hyeon; Kim, Chang Oh; Choi, Jun Yong; Song, Young Goo; Kim, June Myung

doi:10.1620/tjem.219.145

Cited by 5 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[30][31][32] Other studies have found females to be more at greater risk for LA compared with males. [16,33] Age was not a factor associated with LA in this study population unlike what some researchers have reported. [17,34] Evidence exists to show that NRTI associated adipose tissue mitochondrial toxicity plays an important role in the pathogenesis of LA.…”

Section: Discussioncontrasting

confidence: 90%

“…[30][31][32] Stavudine, among the NRTIs has been frequently implicated in the development of LA. [16,33,[35][36][37] However, current drug regimen, including stavudine use was not significantly associated with LA in this study. This may be due to the use of a lower dose of stavudine in our study participants compared studies in which LA was linked to stavudine use.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Lipoatrophy among patients on antiretroviral therapy in Lagos, Nigeria: Prevalence, pattern and association with cardiovascular risk factors

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Lipoatrophy among patients on antiretroviral therapy in Lagos, Nigeria: Prevalence, pattern and association with cardiovascular risk factors

et al. 2015

View full text Add to dashboard Cite

show abstract

“…9 Factors associated with lipoatrophy are sometimes different in the literature. Most studies agree that d4T is an important factor associated with lipoatrophy 2,6,9,[11][12][13] ; despite its less frequent use (35.7%), the prevalence of lipoatrophy was higher in our cohort than the Rwanda and South Africa cohorts who were using more than 90% of HAART regimens containing d4T. This finding may be partly explained by further exposure of our patients to the regimen.…”

Section: Discussionsupporting

confidence: 55%

Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso

Guira

Tiéno

Yaméogo

et al. 2013

J Int Assoc Provid AIDS Care

View full text Add to dashboard Cite

show abstract

“…(27) Obesity and asthma have been linked in the general population (28–31), and HIV-infected individuals are at risk for similar types of metabolic disturbances with development of lipodystrophy and metabolic syndrome with certain antiretroviral agents. (32–34) Potential mechanisms linking obesity to asthma in HIV include changes in adipocytokine levels (such as increases in leptin or decreases in adiponectin) that are common to obesity and HIV-related lipodystrophy and occur secondary to certain antiretroviral medications linked to HIV-related lipodystrophy. (33, 35, 36)…”

Section: Discussionmentioning

confidence: 99%

Asthma diagnosis and airway bronchodilator response in HIV-infected patients

Gingo

Wenzel

Steele

et al. 2012

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Background Despite the high prevalence of respiratory symptoms and obstructive lung disease in HIV-infected persons, the prevalence of bronchodilator reversibility (BDR) and asthma has not been systematically studied during the era of combination antiretroviral therapy (ART). Objective To determine the prevalence of asthma diagnosis and related pulmonary function abnormalities in an HIV-infected cohort and to identify potential mechanisms. Methods A cross-sectional analysis of 223 HIV-infected individuals with data on respiratory symptoms and diagnoses, pulmonary function, sputum cell counts, and asthma-related cytokines and chemokines in serum/sputum. Results Doctor-diagnosed asthma was present in 46 (20.6%) and BDR (≥200ml and ≥12% increase in FEV1 or FVC) in 20 participants (9.0%). Pulmonary symptoms and function were worse in those with doctor-diagnosed asthma. Doctor-diagnosed asthma was independently associated with female sex (p=0.04), body mass index >29.6kg/m2 (vs.<29.6kg/m2) (p=0.03), history of bacterial or Pneumocystis pneumonia (p=0.01), and with not currently taking ART (p=0.04), and in univariate analysis with parental history of asthma (n=180; p=0.004). High sputum eosinophil percentages (>2.3% based on the highest decile) were more likely in those with doctor-diagnosed asthma (p=0.02) or BDR (p=0.02). Doctor-diagnosed asthma tended to be more common with high sputum IL-4 (p=0.02) and RANTES (p=0.02), while BDR was associated with high plasma macrophage inflammatory protein (MIP)-1α (p=0.002), and sputum MIP-1β levels (p=0.001). Conclusion Asthma diagnosis and BDR are prevalent in an HIV-infected outpatient cohort, and associations with family history, obesity, allergic inflammation, prior infection, the absence of ART, and elevated HIV-stimulated cytokines suggest possible mechanisms of HIV-associated asthma.

show abstract

Prevalence of and Clinical Factors Associated with Lipoatrophy in HIV-Infected Koreans Receiving Highly Active Antiretroviral Therapy

Cited by 5 publications

References 35 publications

Lipoatrophy among patients on antiretroviral therapy in Lagos, Nigeria: Prevalence, pattern and association with cardiovascular risk factors

Lipoatrophy among patients on antiretroviral therapy in Lagos, Nigeria: Prevalence, pattern and association with cardiovascular risk factors

Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso

Asthma diagnosis and airway bronchodilator response in HIV-infected patients

Contact Info

Product

Resources

About