Prevalence of Anaplasma phagocytophilum in small rodents in France

Chastagner, Amélie; Moinet, Marie; Perez, Grégoire; Roy, Enakshi; McCoy, Karen D.; Plantard, Olivier; Agoulon, Albert; Bastian, Suzanne; Butet, Alain; Rantier, Yann; Verheyden, Hélène; Cebe, Nicolas; Leblond, Agnès; Vourc’H, Gwenaël

doi:10.1016/j.ttbdis.2016.05.005

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…The difference of A . phagocytophilum prevalence between wood mice and bank voles had already been partly analysed and discussed elsewhere (Chastagner et al ., ). The I .…”

Section: Discussionmentioning

confidence: 97%

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Ecological factors influencing small mammal infection by Anaplasma phagocytophilum and Borrelia burgdorferi s.l. in agricultural and forest landscapes

Perez

Bastian

Chastagner

et al. 2017

Environmental Microbiology

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Small mammals are key components of numerous tick-borne disease systems, as hosts for immature ticks and pathogen reservoirs. To study the factors influencing tick-borne infection in small mammals, we trapped small mammals and collected questing ticks in spring and autumn in 2012 and 2013 at 24 sites in a 10 × 15 km rural landscapes (Brittany, France). Tissue samples were screened by real-time PCR for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato. Of the two dominant small mammal species captured, bank voles (Myodes glareolus) had higher prevalence than wood mice (Apodemus sylvaticus) for both infections, presumably because of specific differences in immunological defenses. Prevalence of infections was higher in 2013 than in 2012, likely because small mammals were fivefold less abundant in 2013, favouring tick aggregation. Bacterial prevalence, which was higher in autumn, was not associated to questing Ixodes ricinus nymph abundance which was six times higher in spring, but rather to the structure of the small mammal community. These findings suggest the involvement of endophilic tick species, I. trianguliceps and/or I. acuminatus, in bacterial transmission. Our study highlights that the entire community of hosts and vectors, and their interactions, should be considered to fully understand the epidemiology of vector-borne diseases.

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“…The difference of A . phagocytophilum prevalence between wood mice and bank voles had already been partly analysed and discussed elsewhere (Chastagner et al ., ). The I .…”

Section: Discussionmentioning

confidence: 97%

“…Thus, Chastagner et al . () proposed exposure to I . trianguliceps ticks as a possible explanation of the highest prevalence found in bank voles compared to wood mice.…”

Section: Discussionmentioning

confidence: 99%

Ecological factors influencing small mammal infection by Anaplasma phagocytophilum and Borrelia burgdorferi s.l. in agricultural and forest landscapes

Perez

Bastian

Chastagner

et al. 2017

Environmental Microbiology

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“…On the other hand, in Europe, prevalence of A. phagocytophilum (22.8%) was reported among rodents belonging to the species Apodemus sylvaticus, Apodemus flavicollis and Myodes glareolus, which were sampled in different regions of France (CHASTAGNER et al, 2016). In Germany, Obiegala et al (2014) found low prevalence of A. phagocytophilum (1.1%) among the rodent species A. sylvaticus, Myodes glareolus and A. flavicollis.…”

Section: Molecular Detection Of Anaplasmataceae Agents Inmentioning

confidence: 95%

Molecular detection of Anaplasmataceae agents in Dasyprocta azarae in northeastern Brazil

Braga

Pereira

Fernandes

et al. 2018

Rev. Bras. Parasitol. Vet.

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Recently, the importance of wild-living rodents for maintenance of pathogens of the family Anaplasmataceae in the environment was investigated. These mammals play a role as reservoirs for these pathogens and act as hosts for the immature stages of tick vectors. The aim of the present study was to investigate the prevalence of Ehrlichia sp. and Anaplasma sp. in 24 specimens of Azara's agouti (Dasyprocta azarae) that had been trapped in the Itapiracó Environmental Reserve, in São Luís, Maranhão, northeastern Brazil, using molecular methods. Four animals (16.7%) were positive for Ehrlichia spp. in nested PCR assays based on the 16S rRNA gene. In a phylogenetic analysis based on the 16S rRNA gene, using the maximum likelihood method and the GTRGAMMA+I evolutionary model, Ehrlichia sp. genotypes detected in Azara's agoutis were found to be closely related to E. canis and to genotypes relating to E. canis that had previously been detected in free-living animals in Brazil. The present work showed the first molecular detection of Ehrlichia sp. in Azara's agoutis in Brazil.

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“…This could in part be due to their immunity to infection or other attributes such as size of rodent. For example, it is thought that older animals may have a higher immunity to infection in comparison to juveniles [33,34]. Alternatively, larger rodents might be more susceptible to infection based on the mere fact that they can sustain a larger population of ticks and hence are more likely to become infected.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of small mammals for tick-borne pathogen infection in northern Mongolia

Pulscher

2018

Infection Ecology & Epidemiology

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Background: Tick-borne pathogens (TBPs) are frequently studied in developed nations but are often neglected in emerging countries. In Mongolia, TBP research is especially sparse, with few research reports focusing upon human and domestic animal disease and tick ecology. However, little information exists on TBPs in small mammals. Methods: In this 2016 cross-sectional pilot study, we sought to uniquely study wildlife for TBPs. We live-trapped small mammals, and tested their whole blood, serum and ear biopsy samples for molecular or serological evidence of Borrelia spp., Rickettsia spp., and Anaplasma spp./Ehrlichia spp. Results: Of 64 small mammals collected, 56.0%, 39.0% and 0.0% of animals were positive by molecular assays for Borrelia spp., Rickettsia spp., and Anaplasma spp./Erhlicia spp., respectively. 41.9% were seropositive for A. phagocytophilum and 24.2% of animals were seropositive for Rickettsia rickettsii. Conclusion: This pilot data demonstrates evidence of a number of TBPs among small mammal populations in northern Mongolia and suggests the need to further investigate what role these mammals play in human and domestic animal disease.

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Prevalence of Anaplasma phagocytophilum in small rodents in France

Cited by 16 publications

References 24 publications

Ecological factors influencing small mammal infection by Anaplasma phagocytophilum and Borrelia burgdorferi s.l. in agricultural and forest landscapes

Ecological factors influencing small mammal infection by Anaplasma phagocytophilum and Borrelia burgdorferi s.l. in agricultural and forest landscapes

Molecular detection of Anaplasmataceae agents in Dasyprocta azarae in northeastern Brazil

A cross-sectional study of small mammals for tick-borne pathogen infection in northern Mongolia

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