Prevalence of anal human papillomavirus infection and intraepithelial neoplasia in renal allograft recipients

Ogunbiyi, Olagunju; Scholefield, J H; Raftery, Andrew T.; Smith, J. H. F.; Duffy, Sean; Sharp, F.; Rogers, K.

doi:10.1002/bjs.1800810313

Cited by 154 publications

(104 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high prevalence of high-risk HPV types in the HIV-positive men is consistent with data from other studies in immunodeficient men, e.g., renal allograft recipients (24). Immunosuppression may permit increased replication of what may otherwise have been a low-level, possibly undetectable HPV infection.…”

Section: Discussionsupporting

confidence: 88%

High Prevalence of Human Papillomavirus Infections in Urine Samples from Human Immunodeficiency Virus-Infected Men

et al. 2005

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 88%

High Prevalence of Human Papillomavirus Infections in Urine Samples from Human Immunodeficiency Virus-Infected Men

et al. 2005

View full text Add to dashboard Cite

“…Renal transplant recipients have been shown to have a significantly higher prevalence of both HPV infection and cervical, as well as anal dysplasia. [10][11][12] In HIV-infected women, HPV DNA is two to three times more frequently isolated from cervical specimens and almost 15 times more frequently from anal swabs compared with HIV-negative controls. HIV-infected women are also approximately five times more likely to develop squamous intraepithelial lesions and cervical cancer is now included in the list of AIDS-defining illnesses.…”

mentioning

confidence: 99%

Abnormal cervical cytology in bone marrow transplant recipients

Sasadeusz¹,

Kelly

Szer

et al. 2001

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Particular human papillomavirus (HPV) subtypes are implicated in the genesis of abnormal cervical cytology and cervical cancer. While most immunocompetent hosts clear HPV infection with no sequelae, some develop premalignant cytological changes of whom a minority subsequently progress to overt carcinoma. Immunocompromised patients, such as renal allograft recipients and HIV-infected individuals, have a higher rate of cytological abnormalities. This is thought to be due to prolonged persistence of virus due to impaired clearance by the immune system. We undertook a retrospective review of the cervical cytology of all women who underwent BMT at two transplant centres and who had cervical smears performed between 1990 and 1998. The rate of cytological abnormalities was significantly higher than in the general population before BMT (ageadjusted odds ratio (OR) 2.2, P = 0.02) and after BMT (OR 7.0, P Ͻ 0.0001). After BMT, allogeneic recipients had a higher rate of abnormalities than did autologous patients (OR 2.6, P = 0.02) although only allogeneic recipients had a higher rate of abnormalities post-BMT compared to pre-BMT (allogeneic OR 6.8, P = 0.004). These observations suggest that pre-transplant disease and treatment factors increase the risk of cytologic abnormalities and that transplant-related factors such as conditioning therapy and immunosuppression further increase this risk. These data suggest that more frequent screening may be required in these at-risk groups, especially allogeneic recipients. Prospective studies are required to further evaluate cytological abnormalities and HPV shedding in these populations. infection by DNA hybridisation, 1 some studies have reported rates of up to 46% in at-risk populations when evaluated by very sensitive tests such as polymerase chain reaction (PCR). 2 HPV consists of over 80 genotypes with various subtypes showing differential tissue tropism and having associations with specific disease manifestations. Current evidence now strongly implicates HPV as a causative agent in cervical cancer, including epidemiological data from large casecontrol studies and the demonstration of HPV genomes in 93% of invasive cervical cancers. Two 'high risk' types, HPV-16 and HPV-18, are found in 40-60% and 10-20% of invasive cancers, respectively. [3][4][5][6] The highest prevalence of HPV-induced cervical cytological changes occurs in the early part of the third decade, 7 while the mean age of invasive carcinoma occurs in the middle of the sixth decade, 8 suggesting a prolonged latent phase of infection before the onset of overt malignant disease. This forms the basis of regular cytological screening, most commonly in the form of a Papanicolou (Pap) smear which detects cytological changes and allows intervention prior to the development of invasive disease.In the immunocompetent host, it has been demonstrated that infection is usually transient, with a reported median duration of 8 months. Seventy percent of women clear new infections within 12 months and 91% clear by 24 month...

show abstract

“…HIV seropositivity, like immunosuppression for organ transplantation or for specific diseases, is associated with AIN and its progression to high-grade squamous intraepithelial lesions. This progression has been observed to occur in about 10-50 % of HIV-positive patients within 2 years [58,59].…”

Section: Diagnosismentioning

confidence: 98%

“…Despite the limited data available about the pathophysiologic effects of HPV (subtypes 16 and 18), a loss of tumor suppressor protein p53 has been described as well as some gene aberrations and alterations [58].…”

Section: Diagnosismentioning

confidence: 99%

The treatment of squamous anal carcinoma: guidelines of the Italian society of colo-rectal surgery

2012

View full text Add to dashboard Cite

The Italian society of colo-rectal surgery (SICCR) is dedicated to improving the study, prevention and management of the diseases of the colon, rectum and anus. One of the aims of the society is to establish guidelines to the treatment of these diseases. These guidelines are based on the international literature and on the best available evidence. Clinical practice guidelines are one of the most important instruments to provide therapeutic decision-making support, based on the best scientific evidence available at the time. Guidelines are advisory and not prescriptive, susceptible to continual variations secondary to innovations and new scientific evidence. These guidelines are a guide for all colo-rectal surgeons and physicians who approach anal cancer.

show abstract

Prevalence of anal human papillomavirus infection and intraepithelial neoplasia in renal allograft recipients

Cited by 154 publications

References 10 publications

High Prevalence of Human Papillomavirus Infections in Urine Samples from Human Immunodeficiency Virus-Infected Men

High Prevalence of Human Papillomavirus Infections in Urine Samples from Human Immunodeficiency Virus-Infected Men

Abnormal cervical cytology in bone marrow transplant recipients

The treatment of squamous anal carcinoma: guidelines of the Italian society of colo-rectal surgery

Contact Info

Product

Resources

About