Prevalence of <i>Helicobacter pylori</i> and the Interest of Its Eradication during the Functional Dyspepsia

Abstract

Functional dyspepsia constitutes by its impact in quality of life and socioeconomic impact areal public health problem (40% of the adult population in the Western world). The prevalence of infection with Helicobacter pylori (HP) in patients with functional dyspepsia is about 30%-70%. The aim of our study is to observe the improvement of functional dyspepsia (FD) after Helicobacter pylori (HP) eradication. Methods: This is a prospective study over a period of 68 months (May 2009-January 2015). We included all patients aged over 15 years, with functional dyspepsia defined by the Rome III criteria. The diagnosis of HP was made by histology and/or PCR. Patients infected with HP were treated in single-blind: standard triple therapy for 7 days or sequential treatment for 10 days. HP eradication control was made after: 3 months, 6 months and one year of treatment. Results: During the study period, 1190 patients were included of which 250 patients (21%) were in functional dyspepsia according to the Rome III criteria. The average age in patients with functional dyspepsia was 49 years [16-80], sex ratio M/F was 0.58 (N = 92/158). 60% of patients were older than 45 years (N = 150). Chronic smoking was found in 20% of patients (N = 50). One hundred and seventy five patients (70%) had HP infection (N = 175). One hundred and sixty five patients received the treatment of Helicobacter pylori (94.28%), 10 patients were lost to follow (5.71%). The eradication of HP was obtained in 98.41% with sequential treatment versus 88.

Comparative Assessment of the Anti-Helicobacter pylori Activity and Gastroprotective Effects of Three Herbal Formulas for Functional Dyspepsia In Vitro

“…It is estimated that over 3 billion people worldwide are infected with H. pylori , with the majority of cases found in developing countries [ 8 ]. Epidemiological studies report the prevalence of H. pylori infection in individuals with functional dyspepsia to range from approximately 30% to 70% [ 9 ]. Despite some controversy, previous clinical findings have shown that eradicating H. pylori leads to symptom improvement in about 70% of infected patients [ 10 ].…”