Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review

Gupta, Palak; Singh, Kiran Kumari; Balodhi, Ashutosh; Jain, Khushi; Deeba, Farah; Salamati, Payman

doi:10.1007/s11686-022-00547-z

Cited by 7 publications

(4 citation statements)

References 67 publications

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“…Anaerobic bacteria and amoebic liver abscesses were not found in this retrospective study, and the incidence of these infections was low in Zhejiang Province, China. Amoebic liver abscess has varying degrees of incidence in France, Mexico, India, and the United Kingdom; [19][20][21][22][23] therefore, metronidazole may not be used in combination with other agents in patients with mild/moderate PLA infection without MODS.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

Li,

Sheng

2024

Preprint

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Aims: PLA (pyogenic liver abscess) has become a common disease, but the percentage of positive cultures of PLA is low. This study summarizes methods for empirically guiding the administration of PLA even without culture results. Method: The clinical data, clinical characteristics, drug resistance, and liver abscess culture results of 398 patients with PLA were recorded and analyzed retrospectively. Results: For the new findings, there was a significant correlation between KP (Klebsiella pneumoniae) and a high incidence of right lobe of PLA,(P<0.001); There was significant correlation between E.coli(Escherichia coli) and a high incidence of left lobe of PLA.༈P<0.001༉ Conclusions: In patients with PLA whose abscess lesion was located in the right liver, KP was the first consideration, and a third-generation cephalosporin or third-generation cephalosporin/enzyme inhibitor was started. When the abscess is located in the left liver, the presence of E. coli should be considered, and treatment with third-generation cephalosporin/enzyme inhibitors or carbapenems should be started. When the abscess is located in the caudate liver, the pathogenic bacteria may be Streptococcus. Metronidazole and ampicillin are not recommended as first-line anti-infective agents for PLA.

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Section: Discussionmentioning

confidence: 99%

A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

Li,

Sheng

2024

Preprint

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“…Amoebiasis is responsible for diarrheal diseases, causing significant morbidity and mortality. Public health efforts should be directed towards its control, and better diagnostic methods should be employed for distinguishing between pathogenic and non-pathogenic species of Entamoeba [ 20 ]. The goal is to eradicate amoebiasis from the planet, but the parasitic life of E. histolytica is ancient and complex and will likely continue to evolve with humans [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report

et al. 2023

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Diarrheal disease continues to be a leading cause of death in children under five years old in developing countries, where it is responsible for the death of approximately half a million children each year. Establishing the cause of diarrheal disease can be difficult in developing areas due to the lack of diagnostic tests, and thus empirical therapies are often required. In these settings, the choice of antibiotic (or the choice to not give it) depends on suspected agents, host conditions and local epidemiology. Herein, we report a representative case of a ten-month-old male patient with severe acute malnutrition (SAM) admitted to the Emergency Paediatric Clinic in Port Sudan for amoebic dysentery complicated by hypovolemic shock and sepsis, treated by target therapy for Entamoeba histolytica infection associated with empiric antibiotic therapy. Due to the absence of clinical improvement, Ciprofloxacin was added to the first-line treatment. This case highlights that in low-income countries amoebiasis, especially in children with SAM, may result in life-threatening complications. Although stool microscopy remains the most used diagnostic test in these settings, a novel inexpensive, easy to use and rapid diagnostic test would be warranted to reach a microbiological diagnosis and guide clinical decision. Further studies will be necessary to identify the patterns of antimicrobial resistance in order to appropriately manage these complicated cases.

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“…The infection has been reported to occur worldwide but is prevalent in tropical and developing countries. The disease affects major organs, such as the colon and liver, with different symptoms or is sometimes asymptomatic [ 13 ]. However, the question of what causes the difference between disease presentation and asymptomatic infection is still unanswered.…”

Section: Discussionmentioning

confidence: 99%

Interleukin 10 (IL-10) Production and Seroprevalence of Entamoeba histolytica Infection among HIV-Infected Patients in South Africa

et al. 2022

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Infections by the parasite E. histolytica are increasing in HIV-infected individuals. Interleukin (IL-10) plays an important role in maintaining the mucosal barrier. Therefore, the seroprevalence of E. histolytica was investigated in relation to the IL-10 serum concentration among HIV- infected patients. A total of 647 blood samples were collected from asymptomatic HIV-infected patients. The Entamoeba histolytica antigen (GALNAC lectin) and serum antibodies were assessed using specific ELISAs (TECHLAB, Virginia, USA). IL10 blood levels were measured using a commercial ELISA test, and the results were analyzed using parametric and non-parametric statistical tests. The Gal/GALNAC lectin was detected in only 0.5% (3/647) of individuals, and the antibodies against E. histolytica were detected in 65.2% (422/647) of the samples. A significant increase in IL-10 levels was found in 68.1% of patients who were sero-negative for E. histolytica antibodies compared to patients who were sero-positive. There is a high level of exposure to E. histolytica among HIV patients in South Africa, although the prevalence of amoebic liver abscesses might be low. This study revealed that elevated levels of IL-10 might be associated with a reduced risk of amebiasis.

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Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review

Cited by 7 publications

References 67 publications

A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report

Interleukin 10 (IL-10) Production and Seroprevalence of Entamoeba histolytica Infection among HIV-Infected Patients in South Africa

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