Prevalence of Alzheimer's disease with diabetes in the Japanese population

Abstract

Background: The aim of the present study was to estimate the prevalence of impaired cognitive function and Alzheimer's disease (AD) in diabetic subjects from Japan. Methods: In the present study, 386 Japanese diabetic subjects aged more than 50 years were initially screened with the 'brief screening test' for AD, and were diagnosed with AD and vascular dementia (VaD) according to the criteria of the NINCDS-ADRDA and the NINDS-AIREN. We compared the prevalence of dementia in diabetic patients with that in ordinary subjects, and analyzed the association of the status of diabetes with dementia including AD and VaD. Results: Forty-six (11.9%) patients were diagnosed with dementia, including 13 (3.4%) patients with AD and nine (2.3%) patients with VaD. Of the 221 subjects aged more than 65 years, 39 (17.6%) patients had dementia, including 13 (5.9%) patients with AD and eight (3.6%) patients with VaD. Compared with ordinary subjects, the prevalence of dementia in the present study was more frequent than the prevalence of dementia for the general population in almost each age group examined. There was also a greater prevalence of AD and VaD in subjects aged over 65 years in the present study. In the present study, AD subjects had significantly higher levels of fasting plasma glucose (FPG; 247.5 1 116.3 mg/dL; P < 0.05) and glycosylated hemoglobin (HbA1c; 8.8 1 1.9%; P < 0.01) compared with nondemented subjects. In AD patients, the odds ratios of FPG and HbA1c were also significantly higher (1.02 and 2.07, respectively; both P < 0.01).Conclusion: The present study shows that diabetes can be associated with impaired cognitive function, particularly AD, in Japanese subjects.

Low education and lack of spousal relationship are associated with dementia in older adults with diabetes mellitus in Nigeria

“…The sample size for the study was calculated using Epi Info version 7. The sample size was based on studies conducted among elderly diabetic patients in Japan and an earlier dementia study in Zaria . The prevalence of diabetes in the Japanese study was 11.9%, and that of diabetes was 2.79% in the Zaria study.…”

“…Studies from developed countries indicated that T2DM is an important risk factor for dementia, especially Alzheimer's disease . These studies examined both biological and environmental factors related to the development of dementia in older adults with T2DM.…”

Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies

“…If these studies have correctly predicted the association, then the future burden of dementia might be even greater than that estimated as the prevalence of diabetes mellitus continues to rise 5 . Early data that linked diabetes mellitus with cognitive impairment came from cross-sectional studies of poor methodological quality 6 . A recent meta-analysis on a similar topic was carried out, and concluded that there is an association between diabetes and dementia 3 .…”

Epidermal Growth Factor Receptor Transactivation Is Necessary for Glucagon-Like Peptide-1 to Protect PC12 Cells from Apoptosis

“…Recently, several reports have revealed an epidemiological association between diabetes mellitus and cognitive impairment, so-called ‘diabetic encephalopathy' [2,3,4,5]. …”