Prevalence of Alpha(α)-Thalassemia in Southeast Asia (2010–2020): A Meta-Analysis Involving 83,674 Subjects

Goh, Lucky Poh Wah; Chong, Eric Tzyy Jiann; Lee, Ping Chin

doi:10.3390/ijerph17207354

Cited by 40 publications

(38 citation statements)

References 49 publications

(41 reference statements)

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“…The carriers of the gene are very common, especially in Southeast Asia, where the prevalence of alpha‐thalassemia‐1 carriers among pregnant women is as high as 6.6% 2 . Consequently, Hb Bart’s disease is the most common cause of hydrops fetalis in Asia, 3 especially in Thailand 4 . The disease is usually lethal, hydropic or causes stillbirth.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of ultrasound algorithm in prenatal diagnosis of hemoglobin Bart’s disease among pregnancies at risk

Harn-a-morn

Wanapirak

Sirichotiyakul

et al. 2022

Intl J Gynecology & Obste

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Objective To evaluate the effectiveness of ultrasound algorithm in diagnosis of fetal Hb Bart’s disease among pregnancies at risk. Methods Pregnancies at risk underwent ultrasound for the first time at 12–14 weeks of gestation and serial ultrasound every 2–4 weeks until 24 weeks to identify pre‐hydropic signs. The invasive procedure was omitted in case of no pre‐hydropic signs. Results A total of 237 fetuses were recruited, including 53 affected and 184 unaffected fetuses. The algorithm has a sensitivity of 100% in the detection of fetal Hb Bart’s disease with a false positive rate of 10.9%. Of the affected group, the mean gestational age at the time of diagnosis was 15.5 ± 2.6 week. 30.8% of all pregnancies at risk underwent invasive procedures. The algorithm had a 70% reduction in the rate of invasive procedures among pregnancies at risk without missing the affected cases. Conclusions The algorithm is highly effective in the early detection of fetal Hb Bart’s disease with a detection rate of 100%, and invasive diagnosis can be avoided in about 70% of cases. Thus, this algorithm should be used as a guideline for prenatal diagnosis of fetal Hb Bart’s disease, especially in geographical areas of high prevalence.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of ultrasound algorithm in prenatal diagnosis of hemoglobin Bart’s disease among pregnancies at risk

Harn-a-morn

Wanapirak

Sirichotiyakul

et al. 2022

Intl J Gynecology & Obste

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“…Alpha-thalassemia is the most prevalent single gene disorder [ 4 ], with a high prevalence of 22.6% in Southeast Asia [ 5 ]. In Singapore, a multiracial Southeast Asian country, 6.4% of Chinese, 4.8% of Malays and 5.2% of Indians were found to be carriers of α-globin gene mutations [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Hemoglobin Bart’s Hydrops Fetalis due to Uniparental Disomy of Chromosome 16

Tan

2021

J Med Cases

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Hemoglobin (Hb) Bart's hydrops fetalis is the most severe form of α-thalassemia and is usually inherited in an autosomal recessive manner. We report a case of Hb Bart's hydrops fetalis due to uniparental disomy of chromosome 16. Antenatal screening showed a low maternal mean corpuscular volume (MCV), while paternal MCV was normal. The fetus was found to have a thickened nuchal translucency during first trimester screening for Down's syndrome. Mid-trimester fetal anomaly ultrasound scan showed fetal cardiomegaly with pericardial effusion, scalp edema, ascites and an elevated middle cerebral arterial peak systolic velocity (MCA PSV). Multiplex polymerase chain reaction (PCR) on DNA from amniocentesis showed that the fetus was homozygous for South East Asian (SEA) type 2 α-globin gene deletion. Chromosome microarray (CMA) showed two regions of absence of heterozygosity (AOH) on the terminal p and q arm of chromosome 16. The rare occurrence of Hb Bart's hydrops fetalis caused by maternal uniparental disomy should be considered in cases of fetal hydrops even in cases where paternal MCV is normal.

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“…Hereditary anemia such as thalassemia and hemoglobin E is also prevalent, especially in the South-East Asian region, and may also cause anemia among pregnant women [ 3 ]. The estimated prevalence of α-thalassemia and hemoglobin E or β-thalassemia in Malaysia is 17% and 34%, respectively [ 4 , 5 ]. In addition, infections such as malaria, human immunodeficiency virus (HIV), and tuberculosis, and chronic diseases such as chronic renal disease and some types of cancer, may cause anemia among pregnant women [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of a theory-based intervention program for pregnant women with anemia: A randomized control trial

Rahman¹,

Idris

Isa

et al. 2022

PLoS ONE

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Anemia in pregnancy is a public health concern. It has been diagnosed in 27% of pregnant women in Malaysia and up to 40% of pregnant women globally. This study aimed to develop and evaluate the effectiveness of an intervention initiative based on the health belief model. The MyPinkMom program was disseminated through a mobile messaging application to pregnant women to educate them on the prevention of anemia in pregnancy. We conducted a two-arm cluster-assignment, single-blinded, randomized control trial at two government antenatal clinics in Selangor. One clinic was randomly chosen as the intervention group, and the other was chosen as the control group. Sixty pregnant women with anemia from the intervention group received the MyPinkMom intervention program in the form of six infographic video clips, and 60 pregnant women with anemia from the control group received routine counseling on anemia in pregnancy. Pregnant women who had anemia secondary to hemoglobinopathy or other chronic diseases were excluded from this study. MANOVA showed significant increases in hemoglobin, knowledge, attitude, subjective norms, and perceived behavioral control scores for adherence to iron supplements, dietary iron, and dietary vitamin C intake (p < 0.001) in the intervention group at week 6. A significant reduction also occurred in dietary tannin intake (p < 0.001) in the intervention group at week 6. The intervention group at week 6 showed a large effect on hemoglobin level increments (partial eta squared, Ƞp2 0.268), dietary iron intake (Ƞp2 0.213), knowledge of anemia in pregnancy (Ƞp2 0.622), subjective norm scores for adherence to iron supplements (Ƞp2 0.167), and reduction in dietary tannin intake (Ƞp2 0.353). Similarly, repeated measures ANOVA showed that changes in hemoglobin levels were significantly different over time (i.e., at baseline, week 6, and week 12) between the intervention and control groups (p < 0.001). Hemoglobin increased rapidly over time among participants in the intervention group but gradually in the control group. To conclude, the newly developed MyPinkMom program that was delivered through a messaging application showed effectiveness in preventing anemia during pregnancy.

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Prevalence of Alpha(α)-Thalassemia in Southeast Asia (2010–2020): A Meta-Analysis Involving 83,674 Subjects

Cited by 40 publications

References 49 publications

Effectiveness of ultrasound algorithm in prenatal diagnosis of hemoglobin Bart’s disease among pregnancies at risk

Effectiveness of ultrasound algorithm in prenatal diagnosis of hemoglobin Bart’s disease among pregnancies at risk

A Rare Case of Hemoglobin Bart’s Hydrops Fetalis due to Uniparental Disomy of Chromosome 16

The effectiveness of a theory-based intervention program for pregnant women with anemia: A randomized control trial

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