Prevalence of Alloimmunization against RBC Antigens in Thalassemia Major Patients in South East Of Iran

Mirzaeian, Amin

doi:10.4172/2155-9864.1000147

Cited by 11 publications

(15 citation statements)

References 16 publications

(24 reference statements)

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“…In particular, there is an increased significant risk of alloimmunization. This consequence of transfusion may result in a hemolytic transfusion reaction and be fatal to the patient …”

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confidence: 99%

“…This consequence of transfusion may result in a hemolytic transfusion reaction and be fatal to the patient. [2][3][4][5] The frequencies of the different blood group antigens are shown to vary among different ethnic populations. Some of these antigens are highly immunogenic and thus increase the risk of alloimmunization in blood recipients, [6][7][8] with the most clinically significant alloantibodies being Rh, Kell, Kidd, and Duffy.…”

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confidence: 99%

“…10 Numerous studies have reported a high frequency of alloimmunization in thalassemia patients: 30% (57/190) in Kuwait, 4.97% (8/161) in India, 5% (72/1435) in Italy, 26.25% (84/320) in Egypt, 22.06% (16/68) in Saudi Arabia, and 3.7% (44/1200) in Greece. 5,[10][11][12][13][14][15][16][17][18][19][20] A similar study of sickle cell anemia patients was conducted in eastern Saudi Arabia and reported expression of alloantibodies in 13.7% of patients (48/350). 3 Another study in the western part of the same country, carried out in 2012-2013 at KAUH, screened 234 sickle cell patients for alloantibodies, discovering that 12.8% (30 patients) expressed alloantibodies.…”

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The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center

et al. 2020

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BACKGROUND Blood transfusion is the first‐line treatment for patients with thalassemia and many sickle cell patients. However, cases of unregulated blood transfusion are shown to carry a high risk of alloimmunization to red blood cells (RBCs), which can lead to a hemolytic transfusion reaction and be fatal to patients. Screening and identification of alloantibodies are, therefore, essential practice in blood transfusion services. Transfusion of phenotyped blood can minimize these risks to patients. STUDY DESIGN AND METHODS A prospective study was carried out on 1015 donors, and a prospective and retrospective study was carried out on 208 multiple transfused patients with β‐thalassemia and sickle cell anemia. Donor and patient samples were subjected to Rh & K typing, and patient samples were also subjected to screening & identification of RBC antibodies. We aimed to determine the prevalence of RBC antigens in thalassemia and sickle cell patients, as well as blood donors, at King Abdulaziz University Hospital and the frequency of alloimmunization in the selected patients. RESULTS The most commonly detected Rh‐phenotype in donors was R1r (32.02%), followed by R1R1 (23.25%). Only 9.16% of donors were positive for the K antigen. The prevalence of Rh and K blood group antigens was also reported: the highest detected Rh‐phenotype was R1r (40.86%) followed by R1R2 (24.04%) with only (6.25%) positive patients for K antigen. The rate of alloimmunization among sickle cell anemia and thalassemia patients was 39.42% and 35.57%, respectively. The highest specificity rates of the alloantibodies were recorded for anti‐E and anti‐K in both patient groups. CONCLUSION The rate of alloimmunization in transfused patients was high and particularly observed against the Rh and K antigens. This study emphasizes the clinical need for typing patient RBCs prior to transfusion so as to provide phenotyped matched blood units and minimize the risks and associated morbidities of alloimmunization. Keeping a database of phenotyped blood donors is essential for the clinically effective and safe management of transfusion patients.

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“…In particular, there is an increased significant risk of alloimmunization. This consequence of transfusion may result in a hemolytic transfusion reaction and be fatal to the patient …”

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center

et al. 2020

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“…The most common used method for detection of alloimmunization, was conventional tube technique (~80%), while gel method was used in minority (~20%) [5][6][7][8]. In the majority of studies, in addition to alloantibodies, autoantibody (8 out of 13 studies) (61.5%) also were detected [1,3,4,12]. Among these studies, the rate of autoimmunization ranges from 1-~19% [4,9].…”

Section: Alloimmunization In Thalassemia Major In Iranmentioning

confidence: 99%

“…The disorder commonly inherited in autosomal recessive manner and is more common in areas with high rate of consanguinity [1][2][3]. Thalassemia belt is an extensive area which extend from Mediterranean east through Middle-East and India to Southeast Asia and south through Africa.…”

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Alloimmunization against Rh and Kell blood groups antigens is the main obstacle for blood transfusion in transfusion dependent thalassemia patients in Iran

Dorgalaleh¹,

Gholami²,

Shokuhiyan³

et al. 2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.

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Major histocompatibility complex (MHC) antigens polymorphism and alloimmunization study in thalassemia patients with febrile non-hemolytic transfusion reaction (FNHTR)

Dadashi

Ostadali

Mohammadi

et al. 2023

Transfusion Clinique et Biologique

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Prevalence of Alloimmunization against RBC Antigens in Thalassemia Major Patients in South East Of Iran

Abstract: The purpose of this study was to determine the frequency of RBC alloantibodies and/or autoantibodies, the types of these antibodies and factors influencing on alloimmunization among multiple-transfused thalassemia major patients.

Cited by 11 publications

References 16 publications

The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center

The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center

Alloimmunization against Rh and Kell blood groups antigens is the main obstacle for blood transfusion in transfusion dependent thalassemia patients in Iran

Major histocompatibility complex (MHC) antigens polymorphism and alloimmunization study in thalassemia patients with febrile non-hemolytic transfusion reaction (FNHTR)

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