Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)

Olano, David González de; Caballer, Belén de la Hoz; López, Rosa Núñez; Muñoz, Luis Sánchez; Agustín, M. Cuevas; Diéguez, M.; Twose, Iván Álvarez; Castells, Mariana; Mora, Luis Escribano

doi:10.1111/j.1365-2222.2007.02804.x

Cited by 215 publications

(170 citation statements)

References 41 publications

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“…The risk of skin tests is not greater than in other patients with hymenoptera venom allergy [101]. Specific IgE levels are normally lower than in the general hymenoptera venomallergic population.…”

Section: Management Of Indolent Systemic Mastocytosis and Anaphylaxismentioning

confidence: 82%

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Key Issues in Hymenoptera Venom Allergy: An Update

Alfaya

Soriano-Gomis

Mera

et al. 2017

J Investig Allergol Clin Immunol

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In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis.

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Section: Management Of Indolent Systemic Mastocytosis and Anaphylaxismentioning

confidence: 82%

“…Hymenoptera stings are the main triggers of anaphylaxis (excluding idiopathic cases) in patients with indolent systemic mastocytosis (ISM) [99,100], with a prevalence of 5%-19% [99,101]. These figures increase in specific forms of the disorder, such as ISM without skin lesions.…”

Section: Management Of Indolent Systemic Mastocytosis and Anaphylaxismentioning

confidence: 97%

Key Issues in Hymenoptera Venom Allergy: An Update

Alfaya

Soriano-Gomis

Mera

et al. 2017

J Investig Allergol Clin Immunol

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“…Szacuje się, że 30-50% dorosłych chorych doświadcza reakcji anafilaktycznych [10,12,14], natomiast u dzieci chorujących na mastocytozę częstość reakcji anafilaktycznych oceniana jest na 5,5-9% [3,5,10]. Objawy zależne od mediatorów oraz ciężkie reakcje anafilaktyczne u chorych na mastocytozę mogą być wyzwalane przez różnorodne czynniki, takie jak: jady owadów błonkoskrzydłych, leki, pokarmy, alkohol, stres emocjonalny, wysiłek fizyczny, zabiegi inwazyjne, zakażenia, czynniki fizyczne oraz niezidentyfikowane czynniki [9][10][11][12][14][15][16][17][18][19][20][21][22][23][24][25]. Według danych z piśmiennictwa nie tylko częstość występo-wania, lecz także czynniki wyzwalające oraz indywidualne ryzyko wystąpienia objawów zależnych od mediatorów oraz reakcji anafilaktycznych różnią się u dzieci i u dorosłych chorujących na mastocytozę [5,10,12,16,17].…”

Section: Mediatory Uwalniane Przez Mastocyty I Ich Znaczenie Biologiczneunclassified

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Czarny¹,

Lange²,

Niedoszytko³

et al. 2017

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StreSzczenieMastocytoza jest rzadką chorobą szpiku charakteryzującą się nadmierną proliferacją i gromadzeniem się mastocytów w skórze i narządach wewnętrznych. U dzieci najczęstsza jest skórna postać tej choroby. Postać układowa pojawia się przede wszystkim u dorosłych. U chorych na mastocytozę, zarówno skórną, jak i układową, mogą występować objawy zależne od mediatorów uwalnianych przez mastocyty, takie jak: świąd skóry, flushing, hipotensja, bóle brzucha, biegunki, bóle głowy oraz reakcje anafilaktyczne. Szacuje się, że reakcje anafilaktyczne występują u około 50% dorosłych i u około 9% dzieci chorych na mastocytozę. Reakcje anafilaktyczne mogą być wywołane przez różne czynniki, m.in. jady owadów błonkoskrzydłych, leki, czynniki fizyczne, wysiłek, zakażenia, alkohol, niektóre pokarmy, alergeny. Do leków związanych z potencjalnym ryzykiem wystąpienia reakcji anafilaktycznych zalicza się: niesteroidowe leki przeciwzapalne, antybiotyki, opioidy, środki kontrastowe oraz leki anestezjologiczne. Odpowiednie przygotowanie do planowanego zabiegu inwazyjnego oraz długoterminowa profilaktyka pozwalają zmniejszyć ryzyko wystąpienia reakcji anafilaktycznej u chorych na mastocytozę. AbStrActMastocytosis is a rare myeloproliferative disease caused by excessive proliferation and accumulation of mast cells in the skin and internal organs. The most common variant of mastocytosis in children is cutaneous mastocytosis. Systemic mastocytosis dominates in adults. Both CM and SM patients suffer from mast cell mediator-related symptoms such as itching, flushing, hypotension, abdominal pain, diarrhea, headache and anaphylaxis. The prevalence of anaphylaxis in patients with mastocytosis has been estimated to be about 50% in adults and about 9% in children. Anaphylaxis may be caused by many triggers including hymenoptera sting, drugs, physical factors, exercise, infections, alcohol, some food types and allergens. Drugs which may provoke anaphylaxis include nonsteroidal anti-inflammatory drugs, antibiotics, opioids, contrast media and muscle relaxants. Appropriate preparation of a patient for medical procedures and long-term prophylaxis allow one to reduce the risk of anaphylaxis in patients with mastocytosis. nadwrażliwość i alergia na leki u chorych na mastocytozę Drug hypersensitivity reactions and allergy in patients with mastocytosis

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“…Over one-half of children with mastocytosis are symptomatic, and the most common symptoms include flushing and pruritis, mostly related to mastocyte release of histamine, prostaglandin-D2 (PG-2), and leukotriene-C4 [1,4,[16][17][18][19]. Bronchospasm, a typical sequela of IgE-mediated reactions, it not a common mediator-related incident in mastocytosis [17,20,21].…”

Section: Clinical Coursementioning

confidence: 99%

“…Patients with mastocytosis experience both immune (IgE-related) and non-immune anaphylaxis, and the overall incidence of anaphylaxis in patients with mastocytosis has been reported to be higher than in the general population [1,16,35,51]. Unlike patients who do not have mastocytosis, however, the serum tryptase level in mastocytosis patients experiencing anaphylaxis does not fall within the normal range at several hours but can remain persistently elevated [18].…”

Section: Preoperative Preparationmentioning

confidence: 99%

Anesthetic considerations in pediatric mastocytosis: a review

Klein

Misseldine

2013

J Anesth

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Mastocytosis is an orphan disease rarely encountered by practicing anesthesiologists. Children with mastocytosis often present for procedures or surgery requiring anesthesia. Because many of the medications commonly used in pediatric anesthesia have been reported to initiate mast cell activation, parents are often very anxious about their child's perioperative experience. Laboratory investigations of serum histamine assays associated with different anesthetic drugs have not been shown to predict mast cell degranulation in these patients. However, the pediatric literature suggests that children with disease limited to the skin rarely suffer serious side effects from anesthesia, and there are no reported fatalities. Preoperative prophylaxis is usually based on expert opinion and case reports. Detailed tables summarizing reports of anesthetic medications used for children with mastocytosis undergoing anesthesia, reported side effects, and suggested prophylaxis regimens are included in this review.

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Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)

Abstract: The prevalence of allergy in mastocytosis is similar to the general population. Anaphylactic symptoms are more prevalent in males and in patients with elevated IgE. The coexistence of atopy does not influence mastocytosis-associated symptoms.

Cited by 215 publications

References 41 publications

Key Issues in Hymenoptera Venom Allergy: An Update

Key Issues in Hymenoptera Venom Allergy: An Update

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Anesthetic considerations in pediatric mastocytosis: a review

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