Prevalence of allergen sensitization among 15,534 patients with suspected allergic diseases in Henan Province, China

Sun, Xiaoxu; Zhao, Junwei; Wang, Qiu-Ya; Shi, Guang; Yang, Jingjing; Ming, Liang

doi:10.12932/ap-160817-0137

Cited by 14 publications

(13 citation statements)

References 17 publications

(21 reference statements)

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“…Los alimentos de origen animal con mayor sensibilización en nuestro estudio fueron huevo, camarón, leche de vaca, pescado, pollo y res; se ha descrito que el huevo y la leche de vaca son alimentos que incrementan el riesgo de desarrollar asma, 20 estos alimentos son frecuentes en la dieta de nuestra población y concuerda con resultados obtenidos en Pakistán, 21 Irán 22 y China, 23 donde se aprecia un patrón similar en la presencia de esos alimentos aunque con diferente frecuencia, sobre todo en adolescentes y adultos. En África se ha encontrado 9 % de alergia alimentaria principalmente a huevo (7 %) y se sugiere que el entorno rural es un factor protector importante para enfermedades alérgicas y alergia alimentaria.…”

Section: Discussionunclassified

Sensibilización alimentaria y factores asociados con el descontrol del asma en el Valle del Yaqui, México

Ramírez-Leyva

Díaz-Sánchez

Ochoa

2021

RAM

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Objetivo: Determinar la frecuencia de sensibilización alérgica a alimentos y los factores asociados al descontrol del asma en pacientes del Valle del Yaqui. Métodos: Estudio analítico transversal en un hospital de segundo nivel en Ciudad Obregón, México. El control del asma se clasificó según la Global Initiative for Asthma, el estado nutricional con el índice de masa corporal, la sensibilización alimentaria con pruebas de punción cutánea y el resto de las variables a través de pregunta directa o registros médicos. Se determinaron las frecuencias de sensibilización y los factores asociados con el descontrol del asma a través de estadística descriptiva e inferencial; se consideró estadísticamente significativo un valor de p < 0.05. Resultados: Se incluyeron 230 pacientes. La frecuencia de sensibilización a por lo menos un alérgeno alimentario fue 79 %. Los alérgenos sensibilizantes más frecuentes fueron huevo, maíz, frijol, camarón y leche de vaca. Conclusiones: Nuestro estudio describe el patrón de sensibilización alimentaria en pacientes con asma y los factores asociados al descontrol de la enfermedad. Es la primera investigación en su tipo que se realiza en esta región de México.

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Section: Discussionunclassified

Sensibilización alimentaria y factores asociados con el descontrol del asma en el Valle del Yaqui, México

Ramírez-Leyva

Díaz-Sánchez

Ochoa

2021

RAM

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“…In Asia, peanut allergy prevalence seems to be low compared to US and certain western countries (76,(89)(90)(91)(92). Cashew nut is one of the most common reported tree nuts causing allergy in Asia (67,70,71,74). However, tree nut allergy prevalence varies significantly across Asia especially between East and Southeast Asia and the Middle East (62,63,66,70,74).…”

Section: Walnutmentioning

confidence: 99%

From Allergen Molecules to Molecular Immunotherapy of Nut Allergy: A Hard Nut to Crack

et al. 2021

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Peanuts and tree nuts are two of the most common elicitors of immunoglobulin E (IgE)-mediated food allergy. Nut allergy is frequently associated with systemic reactions and can lead to potentially life-threatening respiratory and circulatory symptoms. Furthermore, nut allergy usually persists throughout life. Whether sensitized patients exhibit severe and life-threatening reactions (e.g., anaphylaxis), mild and/or local reactions (e.g., pollen-food allergy syndrome) or no relevant symptoms depends much on IgE recognition of digestion-resistant class I food allergens, IgE cross-reactivity of class II food allergens with respiratory allergens and clinically not relevant plant-derived carbohydrate epitopes, respectively. Accordingly, molecular allergy diagnosis based on the measurement of allergen-specific IgE levels to allergen molecules provides important information in addition to provocation testing in the diagnosis of food allergy. Molecular allergy diagnosis helps identifying the genuinely sensitizing nuts, it determines IgE sensitization to class I and II food allergen molecules and hence provides a basis for personalized forms of treatment such as precise prescription of diet and allergen-specific immunotherapy (AIT). Currently available forms of nut-specific AIT are based only on allergen extracts, have been mainly developed for peanut but not for other nuts and, unlike AIT for respiratory allergies which utilize often subcutaneous administration, are given preferentially by the oral route. Here we review prevalence of allergy to peanut and tree nuts in different populations of the world, summarize knowledge regarding the involved nut allergen molecules and current AIT approaches for nut allergy. We argue that nut-specific AIT may benefit from molecular subcutaneous AIT (SCIT) approaches but identify also possible hurdles for such an approach and explain why molecular SCIT may be a hard nut to crack.

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“…4,[12][13][14] The mite mixed (Dermatophagoides pteronyssinus and Dermatophagoides farina) were the most common aeroallergen sensitization in Chinese and Hong Kong, respectively, [Henan Province (22.8%) and Hong Kong (63.0%)]. 9,12 In Thailand, the mite mixed was the most common aeroallergen sensitization (range from 50.1% to 62.2%). 4,13 However, these studies were conducted in Bangkok and Phra Nakhon Si Ayutthaya Province located in central part of Thailand.…”

Section: Introductionmentioning

confidence: 99%

“… 7 The previous studies showed that the prevalence of AR defined by positive SPT range from 9% to 42%. 8 , 9 The prevalence of aeroallergen sensitization varies in different regions and countries. Cat and cedar pollen were the most common aeroallergen sensitization in Sweden and Japan, respectively.…”

Section: Introductionmentioning

confidence: 99%

Aeroallergen Sensitization and Clinical Characteristics of Subjects with Chronic Rhinitis in Chiang Mai, Thailand: A Twenty-Year Retrospective Study

Pothirat

Chaiwong

2021

JAA

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Background:The prevalence of common aeroallergen sensitization in subjects with AR and clinical comparison between AR and Non-AR (NAR) subjects in Thailand remains limited. The primary objective of this study was to illustrate the prevalence of the common aeroallergen sensitization in AR subjects and the differences in clinical characteristics between AR and NAR subjects. Methods: Data were retrospectively collected from all subjects with chronic rhinitis who have visited the Chest and Allergy Clinic in three settings in Chiang Mai, Thailand between January 1998 and December 2018. Clinical characteristics and the result of skin prick test (SPT) to common aeroallergen were collected. Results: A total of 2164 subjects with chronic rhinitis were enrolled, SPT was performed in 1001 (46.3%); 655 (65.4%) and 346 (34.6%) were AR and NAR, respectively. Mite mixed was the most frequent aeroallergen sensitization in subjects with AR both without asthma and with asthma (86.4% and 85.6%) followed by cockroach mixed (54.4% and 58.9%), grass pollen (38.9% and 40.4%), animal dander (15.5% and 19.9%), and mold mixed (5.7% and 11.0%). Polysensitization was higher in younger adults compared to middle aged adult and older adult (72.5%, 67.4%, and 58.7%, respectively, p=0.041). The AR subjects had lower age, earlier age of disease onset, and longer duration of disease (32.6±16.3 vs 40.2±15.4 years, 24 (10-36) vs 34 years (22-45), 3 (1-10) vs 2 years (0-5), respectively, p<0.001). The AR subjects also had more asthma, conjunctivitis, and family history of chronic rhinitis (22.3% vs 15.6%, 25.3% vs 4.3%, and 58.0% vs 43.3%, respectively, p<0.05). Conclusion:The most common aeroallergen for AR (with and without asthma) was mite mixed followed by cockroach mixed and grass pollen. Polysensitization was significant higher in younger adult than middle aged and older adult. AR was significantly associated with asthma, conjunctivitis and family history of chronic rhinitis compared to NAR.

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Prevalence of allergen sensitization among 15,534 patients with suspected allergic diseases in Henan Province, China

Abstract: Background: The prevalence of allergen sensitization varies in different geographic areas and population subsets. This study investigated the prevalence and distribution of inhaled and food allergens among allergic patients in Henan Province, China.

Cited by 14 publications

References 17 publications

Sensibilización alimentaria y factores asociados con el descontrol del asma en el Valle del Yaqui, México

Sensibilización alimentaria y factores asociados con el descontrol del asma en el Valle del Yaqui, México

From Allergen Molecules to Molecular Immunotherapy of Nut Allergy: A Hard Nut to Crack

Aeroallergen Sensitization and Clinical Characteristics of Subjects with Chronic Rhinitis in Chiang Mai, Thailand: A Twenty-Year Retrospective Study

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