Prevalence of Alcohol in Unintentional Opioid Overdose Deaths, 2017-2020

Phillips, Aryn Z.; Post, Lori A.; Mason, Maryann

doi:10.1001/jamanetworkopen.2022.52585

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Here, we found a higher prevalence of current alcohol use disorder in the OD cohort. It is consistent with recent reports that 15%–30% of opioid OD deaths involved alcohol, 53,54 suggesting that the combination of alcohol and opioids likely increases the risk of opioid OD. We also found a lower prevalence of current cannabis use disorder in the OD cohort.…”

Section: Discussionsupporting

confidence: 91%

“…Epidemiological studies show that opioid OD deaths involving polysubstance misuse are more common than those involving opioids alone 52–57 . Here, we found a higher prevalence of current alcohol use disorder in the OD cohort.…”

Section: Discussionsupporting

confidence: 42%

“…Epidemiological studies show that opioid OD deaths involving polysubstance misuse are more common than those involving opioids alone. [52][53][54][55][56][57] Here, we found a higher prevalence of current alcohol use disorder in the OD cohort. It is consistent with recent reports that 15%-30% of opioid OD deaths involved alcohol, 53,54 suggesting that the combination of alcohol and opioids likely increases the risk of opioid OD.…”

Section: Hippocampal Volumementioning

confidence: 89%

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Hippocampal volume loss in individuals with a history of non‐fatal opioid overdose

Todaro,

Li,

Pereira‐Rufino

et al. 2023

Addiction Biology

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Incidence of opioid‐related overdoses in the United States has increased dramatically over the past two decades. Despite public emphasis on overdose fatalities, most overdose cases are not fatal. Although there are case reports of amnestic syndromes and acute injury to the hippocampus following non‐fatal opioid overdose, the effects of such overdoses on brain structure are poorly understood. Here, we investigated the neuroanatomical correlates of non‐fatal opioid overdoses by comparing hippocampal volume in opioid use disorder (OUD) patients who had experienced an opioid overdose (OD; N = 17) with those who had not (NOD; N = 32). Voxel‐based morphometry showed lower hippocampal volume in the OD group than in the NOD group, which on post hoc analysis was evident in the left but not the right hippocampus. These findings strengthen the evidence that hippocampal injury is associated with non‐fatal opioid overdose, which is hypothesized to underlie overdose‐related amnestic syndrome.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 42%

Section: Hippocampal Volumementioning

confidence: 89%

See 1 more Smart Citation

Hippocampal volume loss in individuals with a history of non‐fatal opioid overdose

Todaro,

Li,

Pereira‐Rufino

et al. 2023

Addiction Biology

View full text Add to dashboard Cite

show abstract

“…Alcohol is another respiratory depressant and is involved in an estimated 31 % of opioid overdose deaths ( Phillips et al, 2023 ). Research indicates that approximately 23–26 % of people with OUD have a concurrent alcohol use disorder ( Hser et al, 2017 , Jones and McCance-Katz, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Polysubstance use and post-discharge mortality risk among hospitalized patients with opioid use disorder

Hochstatter,

Nordeck,

Mitchell

et al. 2023

Preventive Medicine Reports

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Lifetime non-fatal overdose experiences among at-risk adolescents and young adults in the emergency department with past-year opioid use in the USA

Seewald,

Bonar,

Bohnert

et al. 2024

Inj Prev

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BackgroundAdolescents and young adults with risk factors for opioid misuse and opioid use disorder are at elevated risk for overdose. We examined prior non-fatal overdose experiences among at-risk adolescents/young adults to inform prevention efforts.MethodsAdolescents/young adults (ages 16–30) in two US emergency departments self-reporting past year opioid misuse or opioid use plus a misuse risk factor completed a baseline survey as part of an ongoing randomised controlled trial. We describe baseline factors associated with (a) overall non-fatal overdose experiences and (b) groups based on substance(s) used during the worst overdose experience.ResultsAmong 771 participants (27.9% male), 40.7% reported a non-fatal overdose experience. Compared with those without a prior overdose experience, those with prior overdose experience(s) were less likely to be heterosexual, and more likely to report a prior suicide attempt and greater peer substance misuse. Regarding the worst overdose experience, substance(s) included: 36.6% alcohol only, 28.0% alcohol and cannabis, 22.6% alcohol with other substance(s) and 12.7% other substance(s) only (eg, opioids). Compared with the alcohol only group, the alcohol and cannabis group were younger and less likely to be heterosexual; the alcohol with other substance(s) group were older and had greater peer substance misuse; and the other substance(s) only group were more likely to be male, receive public assistance, screen positive for anxiety and less likely to be heterosexual.ConclusionsAmong at-risk adolescents/young adults, findings support the need for tailored overdose prevention efforts based on substance(s) used, with consideration of sexuality, mental health and peer substance use.Trial registration numberNCT04550715.

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Prevalence of Alcohol in Unintentional Opioid Overdose Deaths, 2017-2020

Abstract: This cross-sectional study investigates the prevalence of alcohol in unintentional opioid overdose deaths in Illinois from 2017 through 2020.

Cited by 3 publications

References 5 publications

Hippocampal volume loss in individuals with a history of non‐fatal opioid overdose

Hippocampal volume loss in individuals with a history of non‐fatal opioid overdose

Polysubstance use and post-discharge mortality risk among hospitalized patients with opioid use disorder

Lifetime non-fatal overdose experiences among at-risk adolescents and young adults in the emergency department with past-year opioid use in the USA

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