Prevalence of age‐related hearing loss, including sex differences, in older adults in a large cohort study

Homans, Nienke C.; Metselaar, R M; Dingemanse, Gertjan; Schroeff, Marc P. van der; Brocaar, M. P.; Wieringa, Marjan H.; Jong, Rob J. Baatenburg de; Hofman, Albert; Goedegebure, André

doi:10.1002/lary.26150

Cited by 158 publications

(144 citation statements)

References 41 publications

(66 reference statements)

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“…The patient's history specifically excluded the possibility of exposure to noise, but, strictly, at least part of the hearing loss can be attributed to age‐related hearing loss (presbyacusis). However, in a recent study of a general unscreened population of older adults the average age‐related (age group 65–69 years) hearing loss at 4,000 Hz has been reported to be around 45 dB HL for men (Homans et al, ). Since the patient at age 65 years demonstrated a threshold of 60 dB HL at 4,000 Hz (Figure ), other causes may have contributed to the hearing loss, which raises the intriguing question about the possibility for TBL1X (absence) to be a potential contributing factor.…”

Section: Discussionmentioning

confidence: 99%

Ocular albinism with infertility and late‐onset sensorineural hearing loss

Fabian‐Jessing

Vestergaard

Plomp

et al. 2018

American J of Med Genetics Pt A

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Ocular albinism type 1 (OA1) is caused by mutations in the GPR143 gene located at Xp22.2. The manifestations, which are due to hypopigmentation, are confined to the eyes and optic pathway. OA1 associated with late-onset sensorineural hearing loss was previously reported in a single family and hypothesized to be caused by a contiguous gene deletion syndrome involving GPR143 and the adjacent gene, TBL1X. Here, we report on a family with OA1, infertility, late-onset sensorineural hearing loss, and a small interstitial Xp microdeletion including the GPR143, TBL1X, and SHROOM2 genes. In addition, we re-examined a patient previously described with OA1, infertility and a similar Xp deletion with audiologic follow-up showing a late-onset sensorineural hearing loss. Our results raise an intriguing question about the possibility for TBL1X (absence) involvement in this type of hearing loss. However, our study cannot claim a causative relationship and more convincing evidence is needed before the hypothesis can be accepted that TBL1X could be involved in late-onset sensorineural hearing loss and that ocular albinism with late-onset sensorineural hearing loss can present itself as a contiguous gene deletion/microdeletion syndrome. The finding of infertility in all affected male patients demonstrates that this deletion, including the SHROOM2 gene, may be a potentially causative X-linked genetic factor of male infertility.

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Section: Discussionmentioning

confidence: 99%

Ocular albinism with infertility and late‐onset sensorineural hearing loss

Fabian‐Jessing

Vestergaard

Plomp

et al. 2018

American J of Med Genetics Pt A

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“…A recent short-term US longitudinal study found a similar hearing threshold increase of 1 dB per year for adults age 60 years and over (Lee et al 2005). Most US studies report a higher prevalence of hearing loss for men than women across all age ranges; however, more recent studies suggest gender differences might be starting to diminish because of changes in lifestyle (Homans et al 2016). More boys than girls are born each year with congenital hearing loss, and this increased vulnerability of males to hearing loss continues through the life course.…”

Section: Managing Declinementioning

confidence: 95%

A Life Course Approach to Hearing Health

Russ¹,

Tremblay

Halfon

et al. 2017

Handbook of Life Course Health Development

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“…Presbycusis, or age‐related hearing loss (ARHL), is a common cause of sensory impairment globally and thus constitutes a major health and socioeconomic burden on all populations . Presbycusis affects almost one‐third of all individuals >65 years of age . This incidence is increasing as older subsets of the population increase in size .…”

Section: Introductionmentioning

confidence: 99%

Progressive Dominant Hearing Loss (Autosomal Dominant Deafness‐41) and P2RX2 Gene Mutations: A Phenotype–Genotype Study

et al. 2019

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Objectives/Hypothesis P2RX2 encoding P2X purinoreceptor 2 has been identified as the gene responsible for autosomal dominant deafness‐41 (DFNA41) as well as mediating vulnerability to noise‐induced hearing loss (NIHL). The objective of this study was to investigate the audiological and molecular characteristics of P2RX2‐related deafness, with emphasis on its role in NIHL by determining the audiological characteristics of a previously reported six‐generation DFNA41 family with a 10‐year follow‐up. We have also summarized phenotype–genotype correlations of P2RX2‐related deafness in human and mouse models. Study Design We describe clinical longitudinal follow‐up in the DFNA41 family with P2RX2 (p.Val60Leu) mutation and perform a systematic literature search in PubMed and poster presentations on meeting/conference websites to identify current insights into P2RX2‐mediated NIHL. Methods Clinical and physical examinations of the family members were performed, and audiograms were obtained to assess the hearing thresholds. Clinical follow‐up features in this DFNA41 family are presented along with correlation analyses of phenotype–genotype in all reported families with P2RX2‐related deafness. Results Progressive hearing impairment was confirmed by history and by audiological follow‐up testing in all the patients. The onset of hearing loss was between age 25 and 35 years. All affected subjects had bilateral sensorineural hearing loss involving all frequencies with some significant gender differences. Conclusions Our study and the review of the literature suggest that P2RX2 plays a crucial role in predisposition to noise‐induced and age‐related hearing loss. A better knowledge about the P2RX2‐associated genetic variants can help in developing novel therapeutic strategies. Level of Evidence 2b Laryngoscope, 130:1657–1663, 2020

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Prevalence of age‐related hearing loss, including sex differences, in older adults in a large cohort study

Cited by 158 publications

References 41 publications

Ocular albinism with infertility and late‐onset sensorineural hearing loss

Ocular albinism with infertility and late‐onset sensorineural hearing loss

A Life Course Approach to Hearing Health

Progressive Dominant Hearing Loss (Autosomal Dominant Deafness‐41) and P2RX2 Gene Mutations: A Phenotype–Genotype Study

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