Prevalence of adult-onset diabetes among outpatients receiving antipsychotic drugs

Lamberti, J. Steven; Crilly, John; Maharaj, Kumar; Olson, David P.; Costea, Ovidiu Daniel

doi:10.1016/s0920-9964(03)80179-2

Cited by 14 publications

(10 citation statements)

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“…Genetic factors appear to have a key role in the association between schizophrenia and diabetes, since it has been reported that up to 50% of individuals with schizophrenia have a family history of type 2 diabetes, compared with just 4.6% of healthy adult controls (Dynes, 1969; Mukherjee et al 1989; Cheta et al , 1990; Lamberti et al , 2003; Shiloah et al , 2003). In one of the largest chart reviews ever conducted of schizophrenia, Lamberti et al (2003) found a family history of type 2 diabetes in 17% of the total cohort of 436 patients. Importantly, in the cohort of patients who had a positive family history of diabetes, the prevalence of diabetes mellitus was 33%.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of diabetes and impaired glucose tolerance in patients with schizophrenia

2004

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BackgroundA number of studies have examined the prevalence of diabetes mellitus and impaired glucose tolerance in general populations and in those with schizophrenia and other forms of serious mental illness.AimsTo establish whether it is possible to describe accurately comparative rates of diabetes mellitus and impaired glucose tolerance in populations of people with schizophrenia and those without mental illness.MethodReview of current literature.ResultsResearch published in the pre-neuroleptic era suggested that people with severe mental illness were at increased risk of developing glycaemic abnormalities. Recent studies appear to confirm that the prevalence of diabetes and impaired glucose tolerance may be higher in people with schizophrenia than in the general population, and suggest that patients with schizophrenia have impaired glucose tolerance even before they begin treatment.ConclusionsSchizophrenia may be a significant and independent risk factor for both diabetes and impaired glucose tolerance. Current data preclude precise estimates of the prevalence of these conditions among people with schizophrenia.

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Section: Resultsmentioning

confidence: 99%

Prevalence of diabetes and impaired glucose tolerance in patients with schizophrenia

2004

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“…Much of the increased risk can be ascribed to traditional diabetic risk factors, such as family history, physical inactivity and poor diet (figure 2). Up to 50% of people with schizophrenia have a family history of type 2 diabetes [20,21] and a positive family history trebles the risk of developing diabetes in patients with schizophrenia [22]. Poverty and poor access to good nutrition also contribute to the increased prevalence of diabetes.…”

Section: Association Between Schizophrenia and Diabetesmentioning

confidence: 99%

Association between antipsychotic drugs and diabetes

Holt

Peveler

2005

Diabetes Obesity Metabolism

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The link between atypical antipsychotic drugs and the development of diabetes has been hotly debated in the literature. In this review, we attempt to classify the various types of data published and presented in a hierarchical basis. Case reports and retrospective pharmacoepidemiological studies suggest that both conventional and atypical antipsychotic medications are associated with an increased risk of glucose abnormalities or diabetes. Prospective data examining the relationship between atypical antipsychotic drugs and diabetes began to emerge in 2003 and are much less conclusive. Estimates of the attributable risk associated with atypical antipsychotic drugs are low. The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia.

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“…These data provide strong support for the view that patients with schizophrenia are at greater risk of developing glucose intolerance than the general population. Furthermore, studies show that members of families of patients with schizophrenia have a high prevalence of DM (Cheta et al, 1990;Mukherjee et al, 1989;Lamberti et al, 2003).…”

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confidence: 99%