Prevalence of Adenomas and Colorectal Cancer in Average Risk Individuals: A Systematic Review and Meta-analysis

Heitman, Steven J.; Ronksley, Paul E.; Hilsden, Robert J.; Manns, Braden; Rostom, Alaa; Hemmelgarn, Brenda R.

doi:10.1016/j.cgh.2009.05.032

Cited by 217 publications

(186 citation statements)

References 30 publications

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“…In our study, majority of the adenoma and advanced adenomas were found in subjects 50-59 years old followed by the 60-69 year old age group. Our findings have a discrepancy when compared to reports from western countries (Mehran et al, 2003;Heitman et al, 2009;Rex et al, 2009). Moreover, our findings shows that a noticeable number of colorectal neoplasia (11.7%) has been detected among the younger participants (40-49 years old).…”

Section: Discussioncontrasting

confidence: 99%

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Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Sohrabi¹,

Zamani²,

Ajdarkosh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the prime causes of mortality around the globe, with a significantly rising incidence in the Middle East region in recent decades. Since detection of CRC in the early stages is an important issue, and also since to date there are no comprehensive epidemiologic studies depicting the Middle East region with special attention to the average risk group, further investigation is of significant necessity in this regard. Aim: Our aim was to investigate the prevalence of preneoplastic and neoplastic lesions of the colon in an average risk population. Materials and Methods: A total of 1,208 eligible asymptomatic, average-risk adults older than 40 years of age, referred to Firuzgar Hospotal in the years 2008-2012, were enrolled. They underwent colonoscopy screening and all polypoid lesions were removed and examined by an expert gastrointestinal pathologist. The lesions were classified by size, location, numbers and pathologic findings. Size of lesions was measured objectively by endoscopists. Results: The mean age of participants was 56.5 ± 9.59 and 51.6% were male. The overall polyp detection rate was 199/1208 (16.5 %), 26 subjects having non-neoplastic polyps, including hyperplastic lesions, and 173/1208 (14.3%) having neoplastic polyps, of which 26 (2.15%) were advanced neoplasms .The prevalence of colorectal neoplasia was more common among the 50-59 age group. Advanced adenoma was more frequent among the 60-69 age group. The majority of adenomas were detected in the distal colon, but a quarter of advanced adenomas were found in the proximal colon; advance age and male gender was associated with the presence of adenoma. Conclusions: It seems that CRC screening among average-risk population might be recommended in countries such as Iran. However, sigmioidoscopy alone would miss many colorectal adenomas. Furthermore, the 50-59 age group could be considered as an appropriate target population for this purpose in Iran.

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Section: Discussioncontrasting

confidence: 99%

“…Heitman et al reported in their meta-analysis that the prevalence of non-advanced, advanced adenoma and cancer in North America were 17.7%, 5.7% and 0.3%, respectively (Heitman et al, 2009). Researchers from Asian-pacific developed countries have also reported a significant increase of CRC over the last decades.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Sohrabi¹,

Zamani²,

Ajdarkosh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Similar prevalence of adenomas was reported by other authors in higher risk populations [10], while in the general population adenomas were found less frequently. Other studies found in the general population slightly lower or even higher prevalence of adenomas than in our study [11]. The high prevalence of adenomas in our group can be explained by the relatively high age of the studied group.…”

Section: Discussioncontrasting

confidence: 69%

Prevalence of colonic adenomas in patients with metabolic syndrome

Gajecki¹,

Kempiński²,

Poniewierka³

2012

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Introduction: Seventy percent of colonic polyps are adenomas -benign neoplastic tissue deriving from epithelium with various grades of dysplasia. Metabolic syndrome is discussed as one of the risk factors for development of colonic adenomas. Aim: To evaluate the relation between metabolic syndrome and prevalence of colonic polyps. Material and methods: In 2008-2011, 151 patients (aged 50-70 years) from the city of Strzegom were enrolled in a prophylactic programme. Each patient had the following examinations performed: physical examination, abdomen ultrasound, chest X-ray, oesophagogastroduodenoscopy, colonoscopy, ECG and laboratory tests. In females mammography and gynaecological examination were performed, and in males prostate-specific antigen (PSA) level was evaluated. Results: The prevalence of adenomas was higher in patients with metabolic syndrome (33.3% vs. 20.6%, p < 0.05). Also higher prevalence of adenomas larger than 10 mm was found in patients with metabolic syndrome. HDL level above 95 mg% and HDL level 45-95 mg% with fulfilled criteria of metabolic syndrome were determined as risk factors of colonic adenoma development. Conclusions: Metabolic syndrome can be a risk factor for development of colonic adenomas. Adenoma growth can be accelerated in metabolic syndrome. HDL molecules can promote colonic proliferation and formation of adenomas.

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“…Several studies have revealed that age is one of the most important influential factors for colorectal adenoma: An older age (≥65 years) is associated with a higher prevalence of adenoma and advanced adenoma (6,7). In addition, the prevalence of adenoma and advanced adenoma in persons 76-80 years of age is more than double that of persons aged 40-49 years (8).…”

Section: Introductionmentioning

confidence: 99%

Clinical, endoscopic and pathological characteristics of colorectal polyps in elderly patients: Single-center experience

Zhou

Zhang

Sun

et al. 2017

Molecular and Clinical Oncology

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Abstract. Increasing age is a risk factor for the development of colorectal adenomas and advanced adenomas. However, few studies have been published on the features of colorectal polyps in the elderly. The present study aimed to investigate the clinical, enteroscopic and pathological characteristics of colorectal polyps in Chinese elderly patients in a single center (The Central Hospital of Wuhan, Hubei, China). The endoscopic and pathological reports of colonoscopies performed in our center were retrospectively analyzed. A total of 7,795 consecutive patients referred for colonoscopy were evaluated between January 2013 and December 2014. Of the 297 who met the inclusion criteria, 279 polyps were observed in men and 230 in women. Of all the polyps, 263 were non-adenomatous polyps, 104 were non-advanced adenomas and 142 were advanced adenomas. 336 polyps were left-sided and 173 were right-sided. Polyps ≥10 mm were more likely to exhibit an adenomatous component and advanced features, and these findings continued to hold true when the size cut-off was set at 5 mm. The data shown in the present study have revealed that a significant number of polyps lie proximal to the splenic flexure. Thus, evaluation of the whole bowel is particularly important in elderly patients who are undergoing colonoscopy. In addition, the polyp size was associated with the presence of adenoma, and advanced component, diminutive and small polyps should not be ignored in elderly patients.

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Prevalence of Adenomas and Colorectal Cancer in Average Risk Individuals: A Systematic Review and Meta-analysis

Cited by 217 publications

References 30 publications

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Prevalence of colonic adenomas in patients with metabolic syndrome

Clinical, endoscopic and pathological characteristics of colorectal polyps in elderly patients: Single-center experience

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