Prevalence of active infection by herpes simplex virus type 2 in patients with high‐risk human papillomavirus infection: A cross‐sectional study

Bahena-Román, Margarita; Sánchez‐Alemán, MA; Contreras‐Ochoa, CO; Lagunas‐Martínez, Alfredo; Olamendi-Portugal, María; López‐Estrada, Guillermina; Delgado‐Romero, Karina; Guzmán-Olea, Eduardo; Madrid‐Marina, Vicente; Torres-Poveda, Kirvis

doi:10.1002/jmv.25668

Cited by 10 publications

(15 citation statements)

References 27 publications

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“…( Smith et al., 2002 ) found that HSV-2 seropositivity was associated with increased risks of squamous cell carcinoma (OR 2.19, 95% CI 1.41–3.40) and adeno- and adenosquamous cell carcinomas (OR 3.37, 95% CI 1.47–7.74), after adjustment for potential confounders. A cross-sectional study in 2020 observed significant differences in HSV-2 seroprevalence and HSV-2 active infection rates between negative and positive HR-HPV cases ( Bahena-Román et al., 2020 ). Li et al.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the correlation between HSV-2 and HPV infection and cervical lesions, Smith et al (Smith et al, 2002) found that HSV-2 seropositivity was associated with increased risks of squamous cell carcinoma (OR 2.19,) and adeno-and adenosquamous cell carcinomas (OR 3.37, 95% CI 1.47-7.74), after adjustment for potential confounders. A cross-sectional study in 2020 observed significant differences in HSV-2 seroprevalence and HSV-2 active infection rates between negative and positive HR-HPV cases (Bahena-Romań et al, 2020). Li et al (Li and Wen, 2017) used eight datasets and a sample of 8,184 participants, finding that HSV-2 was associated with cervical cancer after adjusting for HR-HPV (OR adj 1.90, 95% CI 1.09-3.34), suggesting that HSV-2 serostatus may serve as an independent predictor of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

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Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes

Disi

Zhang

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionHuman papillomavirus (HPV) infection, especially persistent high-risk HPV, is associated with cervical cancer. Female reproductive tract microecological disorders and lower genital tract infections have been increasingly correlated with HPV infection and cervical lesions. Due to their common risk factors and transmission routes, coinfection with other sexually transmitted infections (STIs) has become a concern. Additionally, the clinical significance of Mycoplasma subtypes appear to vary. This study aimed to assess the correlations between common STIs and HPV infection, and to investigate the clinical significance of Mycoplasma subtypes.MethodsWe recruited 1,175 patients undergoing cervical cancer screening at the Peking University First Hospital gynecological clinic from March 2021 to February 2022 for vaginitis and cervicitis tests. They all received HPV genotyping and detection of STIs, and 749 of them underwent colposcopy and cervical biopsy.ResultsAerobic vaginitis/desquamative inflammatory vaginitis and STIs (mainly single STIs) were found significantly more often in the HPV-positive group than in the HPV-negative group. Among patients with a single STI, rates of infection with herpes simplex virus type 2 or UP6 in the HPV-positive group were significantly higher than in the HPV-negative group (ORadj: 1.810, 95%CI: 1.211–2.705, P=0.004; ORadj: 11.032, 95%CI: 1.465–83.056, P=0.020, respectively).DiscussionThrough detailed Mycoplasma typing, a correlation was found between different Mycoplasma subtypes and HPV infection. These findings suggest that greater attention should be paid to detecting vaginal microecological disorders in those who are HPV-positive. Further, lower genital tract infections, including both vaginal infections and cervical STIs, are significantly more common among women who are HPV-positive and who thus require more thorough testing. Detailed typing and targeted treatment of Mycoplasma should become more routine in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes

Disi

Zhang

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Some recent studies have shown the prevalence of co-infection with herpes simplex virus (HSV) among patients suffering from high-risk human papillomavirus (HR-HPV) [ 59 ]. High incidence rates for such co-infections have been observed because of the silent seroprevalence of HSV in approximately 80% of the population worldwide [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…The major risk factors behind such an infection have been risky sexual behavior and a previous history of HPV and HSV infection [ 61 ]. A study reported the co-infection with EBV, HPV, CMV, and HSV-1 in patients suffering from diabetes mellitus type 2 (DM2) [ 59 ]. The repercussions of the disease spread were linked to the modification of microbiota components that otherwise control the normal functioning of the human body.…”

Section: Resultsmentioning

confidence: 99%

Tracking HPV Infection, Associated Cancer Development, and Recent Treatment Efforts—A Comprehensive Review

Malik¹,

Sah

Muhammad

et al. 2023

Vaccines

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Human papillomaviruses (HPVs) are high-risk causative factors for HPV infection. This infection does not come alone; it is often seen with co-infection with other viruses and acts as a causative agent for several malignancies. The major purpose of this comprehensive study was to highlight some recent advances in biotechnology associated with HPV infection, including understanding its host interactions and cancerous progression. A systematic research strategy was used to gather data from recent, and the most advanced published electronic sources. The compiled data explain the recent understanding of biology, host–viral interaction cycles, co-infection with other viral diseases, and cellular transformation toward malignancies associated with HPV. In recent years, some vaccination protocols have been introduced in the form of live attenuated, subunit, and DNA-based vaccines. Moreover, some strategies of nanotechnology are being employed to synthesize drugs and vaccines with a whole new approach of plant-based products. The data are immense for the proposed research question, yet the need is to implement modern follow-up screening and modern therapeutics at the clinical level and to conduct wide-scale public awareness to lessen the HPV-related disease burden.

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“…1 Indeed, both HPV and HSV-2 have been reported to be associated with cervical cancer. 2 HPV is a DNA virus that infects cutaneous and mucosal epithelia causing warts or benign lesions. 3 However, the majority of infections resolve clinically after several weeks.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus and herpes simplex virus infections in patients with mucocutaneous lesions can be linked to host TBX-21 gene polymorphism

Bakir¹

2021

Zanco J. Med. Sci.

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Background and objective: Human papillomavirus (HPV) and herpes simplex-2 (HSV-2) are the common cause of genital lesions in women. The variation in host genetic makeup can determine the consequence of a viral infection in that host. T-bet gene polymorphism has been associated with the incidence of several types of infections. This study investigates the impact of T-bet polymorphism on the incidence of HPV and HSV in genital lesions. Methods: 215 women, including 71 HPV infected, 72 HSV-2 infected, and 72 controls were enrolled. Viral genotyping was done on genital swab samples using Realtime PCR. In all participants, the extracted DNA from blood was tested for T-bet gene variation at Ch17.rs17244587 G>A site using ARMS-PCR. ELISA was done to participants sera to detect HSV-1 IgM. Results: Genotyping of HPV infection revealed that (73.0%) were at low risk. Most individuals (72.5%) were homozygous GG, while (20.9%) were heterozygous AG and (6.5%) were homozygous AA, of which 92.8% were HSV-2 infected patients. None of 18 (8.4%) HSV-1-IgM positive women were homozygous AA. Conclusion: T-bet gene allele A appears to be linked with more incidence of HSV-2 in genital lesions, but such influence was not observed for HPV genotypes and HSV-1. Keywords: HPV genotypes; HSV-2 infection; Genital lesion; T-bet polymorphism.

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Prevalence of active infection by herpes simplex virus type 2 in patients with high‐risk human papillomavirus infection: A cross‐sectional study

Cited by 10 publications

References 27 publications

Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes

Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes

Tracking HPV Infection, Associated Cancer Development, and Recent Treatment Efforts—A Comprehensive Review

Human papillomavirus and herpes simplex virus infections in patients with mucocutaneous lesions can be linked to host TBX-21 gene polymorphism

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