Prevalence of abnormal urinary albumin excretion in elderly people: a Spanish survey

Robles, Nicolás Roberto; Félix, Francisco Javier; Fernández-Bergés, Daniel; Pérez-Castán, José F.; Zaro, María José; Lozano, Luís; Alvarez-Palacios, P.; Garcia-Trigo, Antonio; Tejero, V.; Morcillo, Yolanda; Hidalgo, Á.

doi:10.1007/s11255-013-0380-8

Cited by 11 publications

(6 citation statements)

References 35 publications

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“…The etiology of CKD in the elderly population is known to be different from that in the younger population. In a Spanish series, albuminuria in subjects older than 65 years was more frequently associated with diabetes and hypertension compared with the younger subjects [33], and improved insulin sensitivity due to moderate alcohol intake [27] may be associated with a beneficial effect on proteinuria risk in the old group. The inverse association of alcohol intake with eGFR decline or incident low eGFR was not different according to sex, but an inverse association of alcohol intake with eGFR decline was observed in the young group and a J-shape association was seen in the old group.…”

Section: Discussionmentioning

confidence: 99%

Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data

2019

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To evaluate the association between alcohol intake and incident chronic kidney disease measures as well as the sex differences in this association, we analyzed health screening data of 14,190,878 adults who underwent health screening ≥3 times and had glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and normal proteinuria at baseline. eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration equation. Proteinuria was defined as ≥1+ dipstick proteinuria and low eGFR as <60 mL/min/1.73 m2. The risk of incident proteinuria and low eGFR was analyzed with an extended Cox model with alcohol intake level as a time-varying determinant and the annual change of eGFR with generalized linear model. A J-shape association of alcohol intake with the incident proteinuria was observed in men (adjusted hazard ratio [aHR], 0.961, 95% confidence interval [CI], 0.953–0.970 in men drinking alcohol <10 g/day; aHR 1.139, 95% CI, 1.123–1.154 in men drinking alcohol ≥40 g/day, compared with non-drinking men), and a positive association was seen in women (aHR, 1.034, 95% CI, 1.023–1.044 in women drinking alcohol <10 g/day; aHR, 1.094, 95% CI, 1.034–1.158 in women drinking alcohol ≥40 g/day, compared with non-drinking women). In both sexes, an inverse association of alcohol intake with the annual eGFR decline and incident low eGFR was observed. This study observed a beneficial effect of moderate alcohol intake on incident proteinuria in men and a protective effect of alcohol intake of any amount on the annual eGFR decline and incident low eGFR in both sexes. The long-term implications of these observations need to be elucidated with future studies.

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Section: Discussionmentioning

confidence: 99%

Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data

2019

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“…Recently, numerous population‐based studies had demonstrated that the elderly population showed a high prevalence of albuminuria. For example, the prevalence of albuminuria was 10.9% in a Spanish elderly population , 21.4% in a Chinese elderly population . In this study, the percent of participants with albuminuria was 23.6%, and the prevalence of albuminuia was higher in diabetes (28.1%) and hypertension group (29.0%).…”

Section: Discussionmentioning

confidence: 45%

“…It plays an important role in monitoring the progression of diabetic nephropathy and cardiovascular disease . Recently, many population‐based studies show a high prevalence of albuminuria in elderly population. So it is relevant to screen and monitor albuminuria in elderly population.…”

Section: Introductionmentioning

confidence: 99%

Second Morning ACR Could Be the Alternative to First Morning ACR to Assess Albuminuria in Elderly Population

Wang

et al. 2015

Clinical Laboratory Analysis

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“…The reported prevalence rates of albuminuria in the general population have varied between ethnic groups, suggesting an association between albuminuria and genetic background and environmental factors [18,19,20,21,22]. Previous studies conducted in South Korea have included relatively small sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Related Risk Factors of Albuminuria in Korean Adults: The 2011 Korea National Health and Nutrition Examination Survey

et al. 2014

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Background/Aims: Albuminuria is known to be associated with an increased risk for cardiovascular morbidity and mortality even in the general population. We aimed at investigating the prevalence and related risk factors of albuminuria among Korean adults. Methods: This study was based on data collected during the 2011 Korea National Health and Nutrition Examination Survey. A total of 5,365 Korean adults were included in the general population group, and 3,282 of these participants were included in the nondiabetic, nonhypertensive population group. Albuminuria was defined by a urine albumin-to-creatinine ratio value within the range of 3.4-34 mg/mmol (30-300 µg/mg). Results: The overall prevalence of albuminuria was 5.2% of the general population and 2.1% of the nondiabetic, nonhypertensive population. Factors associated with the risk of albuminuria in the general population were age, systolic blood pressure (SBP), glycated hemoglobin (HbA_1c) level in men, and SBP and HbA_1c level in women. In the nondiabetic, nonhypertensive population, age and fasting plasma glucose levels were significantly associated with an increased risk for albuminuria in men, and with central obesity, triglyceride level and smoking status in women. Conclusion: Albuminuria is prevalent in the nondiabetic, nonhypertensive population as well as general population of Korea. The increased risk of albuminuria was independently associated with several cardiovascular risk factors in the general population, and also in the nondiabetic, nonhypertensive population.

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Prevalence of abnormal urinary albumin excretion in elderly people: a Spanish survey

Abstract: A high prevalence of abnormal UAER in elderly people was detected in a randomly selected sample of Spanish general population. In most elderly patients, microalbuminuria was associated with high blood pressure and, less frequently, with diabetes mellitus.

Cited by 11 publications

References 35 publications

Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data

Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data

Second Morning ACR Could Be the Alternative to First Morning ACR to Assess Albuminuria in Elderly Population

Prevalence and Related Risk Factors of Albuminuria in Korean Adults: The 2011 Korea National Health and Nutrition Examination Survey

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