Prevalence of abdominal aortic aneurysm in patients with high cardiovascular risk

Saucedo, M.A. Cornejo; García-Gil, Daniel; Romero, Fernando; Rego, Ana Torres do; Romero, Luisa; Sala, Enrique Rodilla; Guerra, Gonzalo; Martínez, Javier Villanueva; Casas-Rojo, José Manuel; Macho, J. Torres; Casasola-Sánchez, G. García de

doi:10.1016/j.rceng.2018.09.001

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Based on our results, the frequency of AAA in our study population was 2.2%. In a review by Sprynger et al in 2019, the prevalence of the AAA in elderly population older than 65 years of age in the Europe was reported to decrease to 4% in the last decades, but there are still reports about that it may reach up to 8% associated with the study population's characteristics [12–14] . Our patients were recruited from our cardiology department's echocardiography laboratory, and had very heterogenous clinical backgrounds and indications for echocardiographic assessments.…”

Section: Discussionmentioning

confidence: 99%

Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm

2021

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Abdominal aortic aneurysm is a life threatening disease. Most of the patients diagnosed incidentally because of the asymptomatic nature of this disease. This study aimed to determine the frequency of abdominal aortic aneurysm and evaluate the value of opportunistic screening during transthoracic echocardiography. A total of 5138 patients referred for echocardiographic evaluation for any reason were screened for abdominal aortic aneurysm between November 2014 to July 2019. The aneurysm was defined as an abdominal aorta with a diameter greater than 30 mm, or segmental dilatation of more than 50% of its size in non-dilated parts. The overall frequency of abdominal aortic aneurysm was 2.2% (n = 109) in the study population. Male sex ( P < .001), older age ( P < .001), presence of diastolic dysfunction ( P = .036), hypertension ( P < .001), coronary artery disease ( P < .001), and hyperlipidemia ( P < .001) were associated with abdominal aortic aneurysm. Patients with aneurysm had significantly increased diameters of the aortic trunk ( P < .001) and ascending aorta ( P < .001), significantly thicker interventricular septum ( P < .001) and posterior wall ( P < .001), significantly increased end-diastolic diameter ( P < .001) and enlarged left atrium ( P < .001), and significantly decreased ejection fraction ( P < .001). The mostly met criteria for screening abdominal aortic aneurysm in international guidelines was the age of the patients. Based on the results of this study, screening patients over 60 years of age who undergo a transthoracic echocardiography for any reason would be beneficial to detect an asymptomatic abdominal aortic aneurysm in Turkish population.

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Section: Discussionmentioning

confidence: 99%

Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm

2021

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“…La prevalencia de aneurismas en nuestra muestra se situó en el 2,6% (11 pacientes identificados en el cribado y otros cinco a los que no se les realizó por estar ya intervenidos). Comparando con la prevalencia de aneurismas de otros estudios 11 , 13 , 14 , la prevalencia en nuestra muestra es baja. Pensamos que como la muestra no fue aleatoria, a pesar de priorizar a pacientes con riesgo conocido, puedan ser pacientes con una situación basal mejor y con un mejor control de los factores de riesgo, ya que son los pacientes que acuden con más asiduidad al centro los que se captaron con más facilidad.…”

Section: Discussionunclassified

“…La prevalencia estimada en diversos estudios de nuestro medio se sitúa entre el 4-8% 11 , 13 , 14 , en función del perfil de riesgo de los pacientes incluidos.…”

Section: Introductionunclassified

Cribado mediante ecografía de aneurisma de aorta abdominal en varones con factores de riesgo en Atención Primaria

Donoso¹,

Ramos²,

Velasco³

et al. 2022

Atención Primaria

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Objetivo Describir la implantación de cribado ecográfico de aneurisma de aorta abdominal (AAA) en nuestra zona básica a los varones entre 65 y 79 años y que tuviera algún factor de riesgo identificable para desarrollar AAA: tabaquismo o antecedentes del mismo, hipertensión, antecedentes familiares de aneurisma, aneurisma en otras localizaciones y ateroesclerosis clínica: infarto agudo de miocardio, claudicación intermitente o ictus. Analizar el rendimiento de dicho cribado. Emplazamiento Atención Primaria. Participantes e intervenciones Se ofreció cribado a 656 pacientes, lo que supone un 40% de la población diana de 1.658 pacientes, al tener que interrumpirse prematuramente por la pandemia COVID-19 y se realizaron 608 exploraciones ecográficas. Mediciones principales Cobertura del programa de cribado, prevalencia de aneurismas de aorta abdominal, prevalencias de tabaquismo y otros factores de riesgo en pacientes con/sin aneurisma. Resultados Se encontraron 19 pacientes con aortas ectásicas (25-29 mm) y 11 con aneurismas de aorta abdominal (1,81%). Cinco eran fumadores activos (45%, frente al 20% de toda la muestra) y seis eran exfumadores. Ninguno de los pacientes con aneurisma era no fumador. Siete de ellos eran hipertensos. Conclusiones La prevalencia de aneurismas en nuestra muestra se situó en el 2,6%, siendo más baja de lo esperada. La amplia utilización de la ecografía y la progresiva generalización de la misma en el ámbito de la Atención Primaria debería suponer una disminución en el número de AAA sin diagnosticar.

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Identification of a Plasma Microrna Signature as Biomarker of Subaneurysmal Aortic Dilation in Patients with High Cardiovascular Risk

Rego

Barrientos

Ortega‐Hernández

et al. 2020

JCM

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Patients with subaneurysmal aortic dilation (SAD; 25–29 mm diameter) are likely to progress to true abdominal aortic aneurysm (AAA). Despite these patients having a higher risk of all-cause mortality than subjects with aortic size <24 mm, early diagnostic biomarkers are lacking. MicroRNAs (miRs) are well-recognized potential biomarkers due to their differential expression in different tissues and their stability in blood. We have investigated whether a plasma miRs profile could identify the presence of SAD in high cardiovascular risk patients. Using qRT-PCR arrays in plasma samples, we determined miRs differentially expressed between SAD patients and patients with normal aortic diameter. We then selected 12 miRs to be investigated as biomarkers by construction of ROC curves. A total of 82 significantly differentially expressed miRs were found by qPCR array, and 12 were validated by qRT-PCR. ROC curve analyses showed that seven selected miRs (miR-28-3p, miR-29a-3p, miR-93-3p, miR-150-5p, miR-338-3p, miR-339-3p, and miR-378a-3p) could be valuable biomarkers for distinguishing SAD patients. MiR-339-3p showed the best sensitivity and specificity, even after combination with other miRs. Decreased miR-339-3p expression was associated with increased aortic abdominal diameter. MiR-339-3p, alone or in combination with other miRs, could be used for SAD screening in high cardiovascular risk patients, helping to the early diagnosis of asymptomatic AAA.

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Prevalence of abdominal aortic aneurysm in patients with high cardiovascular risk

Cited by 3 publications

References 34 publications

Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm

Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm

Cribado mediante ecografía de aneurisma de aorta abdominal en varones con factores de riesgo en Atención Primaria

Identification of a Plasma Microrna Signature as Biomarker of Subaneurysmal Aortic Dilation in Patients with High Cardiovascular Risk

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