Several protozoan parasites have been found infecting the edible oysters, hence deteriorating the meat quality. Protozoan parasites such as, Tetrahymena rostrata and Callimastix equi infested the edible oyster in Sundarbans region, West Bengal, India, are first record from this region. Due to filter feeding habit of the organisms, oysters provides excellent ecological services in regard to efficient cleaning of infectious agents from surrounding water as a potential measure to improve water quality. However, these environmental benefits are associated with public heath risks from contaminated oysters intended for human consumption.