Prevalence of 25-hydroxy vitamin D deficiency among type 2 diabetic subjects of South India

Palazhy, Sabitha; Viswanathan, Vijay; Muruganathan, A

doi:10.1007/s13410-016-0496-3

Cited by 8 publications

(10 citation statements)

References 17 publications

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“…Scragg et al [25] found that body mass index was significantly inversely correlated with serum vitamin D concentrations after adjusting for other covariates. A similar observation was reported by in a study conducted among Indian patients by Palazhy et al [11]. This inverse association between vitamin D and BMI is possibly connected to glycaemic control.…”

Section: Discussionsupporting

confidence: 89%

“…A study conducted in Saudi Arabia reported a prevalence of 59.8% of vitamin D deficiency and 38.6% insufficiency [5], meaning that over 98% of the study participants had suboptimal levels of vitamin D. In India, 32.1% and 34.6% of type 2 diabetics had vitamin D deficiency and insufficiency respectively [6]. Table 5 shows the prevalence of vitamin D deficiency among several study populations [5-11]. The lower prevalence of Vitamin D deficiency in our population could be partly attributable to climate; tropical countries experience greater and lengthier sun exposure compared to European, some Asian and American countries.…”

Section: Discussionmentioning

confidence: 99%

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The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya

et al. 2019

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IntroductionThe prevalence of diabetes mellitus is rising at an alarming rate, calling for more insights into its pathogenetic mechanisms, and other factors involved in its progression. The prevalence of vitamin D deficiency is higher in diabetic compared to non-diabetic patients, and is associated with poor glycaemic control. This has not been documented among diabetic patients in Kenya. Aims: to determine the prevalence of hypovitaminosis D among type 2 diabetic patients at Kenyatta National Hospital in Nairobi, Kenya.MethodsWe recruited type 2 diabetic patients on follow-up at Kenyatta National Hospital. Measurements of height, weight and waist/hip ratios were taken. We drew 6mls of peripheral blood to determine vitamin D, zinc and HbA1c levels.ResultsA total of 151 participants were recruited, with 69.5% females and mean age of 58.2 years. Hypertension was found in 72.8% of the participants, and obesity in 37.7%. The mean HbA1c levels were 8.46%, and 62.9% had poor glycaemic control. The mean vitamin D level was 31.40ng/ml. Vitamin D deficiency and insufficiency was found in 38.4% and 21.9% of the participants respectively. We found a significant inverse correlation between vitamin D and glycaemic control (r = -0.09, p = 0.044) and vitamin D and BMI (r = - 0.145, p = 0.045).ConclusionIn this study population on long-term follow-up for diabetes, there was high prevalence of vitamin D deficiency. This forms a basis for further management of patients with poor glycaemic control. Further studies are needed to document the causal association between poor glycaemic control and vitamin D deficiency.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya

et al. 2019

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“…The recent Hitachi Health Study (41) conducted in Japanese adults concluded that higher circulating vitamin D was associated with a lower risk of T2DM, and this association was stronger among individuals with prediabetes. A study conducted in South India among 4628 patients with T2DM had shown that 71•4 % were vitamin D deficient, 15 % were vitamin D insufficient and 13•6 % were found to have normal 25(OH)D levels (49) . Among the participants of the Asian Indian Diabetic Heart Study/Sikh Diabetes Study, 83% of T2DM participants was vitamin D deficient compared with 68% among normoglycaemic controls (43) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

et al. 2020

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The present study assessed the prevalence of vitamin D deficiency in an urban south Indian population in individuals with different grades of glucose tolerance. A total of 1500 individuals (900 normal glucose tolerance (NGT), 300 prediabetes and 300 with type 2 diabetes mellitus (T2DM)) who were not on vitamin D supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study follow-up study. Anthropometric, clinical examination and biochemical investigations (25-hydroxyvitamin D (25(OH)D), insulin, glycated Hb (HbA1c) and serum lipids) were measured. Vitamin D deficiency was defined as serum 25(OH)D < 20·0 ng/ml, insufficiency as 20–29·9 ng/ml and sufficiency as ≥30 ng/ml. Of the 1500 individuals studied, 45 % were males and the mean age was 46 (sd 12) years. Vitamin D levels lowered with increasing degrees of glucose tolerance (NGT: 21 (sd 11); prediabetes: 19 (sd 10); T2DM: 18 (sd 11) ng/ml, P < 0·001). The overall prevalence of vitamin D deficiency was 55 % and was significantly higher among individuals with T2DM (63 %) followed by prediabetes (58 %) and NGT (51 %) (Pfor trend < 0·001). Women had 1·6 times the risk of vitamin D deficiency compared with men (unadjusted OR 1·6 (95 % CI 1·3, 2·0) and adjusted OR 1·6 (95 % CI 1·2, 1·9)). However, there was no increasing trend observed with increasing age. The prevalence of abdominal obesity (66 v. 49 %), generalised obesity (80 v. 64 %), the metabolic syndrome (45 v. 37 %) and insulin resistance (38 v. 27 %) was significantly higher in those with vitamin D deficiency compared with those without. This study shows that vitamin D deficiency is highly prevalent in this urban south Indian population and was higher among individuals with T2DM and prediabetes compared with those with NGT.

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“…A negative correlation between serum 25(OH)D levels and BMI has been observed by many researchers. [ 9 10 11 12 13 14 15 26 ] We also observed a negative correlation between serum 25(OH)D levels and BMI, though it was not statistically significant. The 25(OH)D levels were also similar in different obesity categories in this study.…”

Section: Discussionmentioning

confidence: 57%

“…Palazhy et al noticed no direct correlations between BMI and 25(OH)D level. [ 26 ] We found no correlations of 25(OH)D levels with body weight and height. In a study on 250 overweight and obese adults of different ethnicities, McGill et al demonstrated that the serum level of vitamin D3 was inversely related to weight.…”

Section: Discussionmentioning

confidence: 62%

Vitamin D status of overweight and obese Bangladeshi adults

Paul

Kamrul-Hasan

Chanda

et al. 2020

J Family Med Prim Care

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Background: Both obesity and vitamin D deficiency are pandemics and both have influences on cardiovascular parameters. The reported prevalence of vitamin D deficiency in obesity is high. Data relating to vitamin D status in obese is currently lacking in Bangladesh. Objective: To discover the vitamin D status in Bangladeshi overweight and obese adults. Subjects and Methods: This cross-sectional study, conducted in a specialized endocrine center of Bangladesh, evaluated 500 consecutive overweight or obese subjects, diagnosed according to body mass index (BMI) categories applicable to the south Asian population. Serum 25(OH)D was measured by using the enzyme-linked fluorescent assay (ELFA) method, and the cutoffs described by the Endocrine Society were used to define vitamin D status. Results: The mean age of the study subjects was 45.85 (±11.41) years; most (59.6%) of them were in the age group 40–59 years; almost three-fourth (72.4%) were females; an almost equal number of them came from urban (33.8%), semi-urban (29.6%), and rural (36.6%) areas; three-fourth (74.2%) were homemaker. Their mean BMI was 29.54 (±3.11) kg/m 2 ; the frequencies of overweight, class I obesity, class II obesity, and class III obesity were 27.6%, 57.4%, 12.2%, and 2.8%, respectively. The mean serum 25(OH)D level was 25.25 (±11.97) ng/mL. 27.4% were sufficient, and 33.4% were insufficient for vitamin D, whereas 39.2% had vitamin D deficiency. The 25(OH)D level did not differ across different age groups, gender, residence, education status, occupation, and income status. The 25(OH)D levels were also indifferent in overweight, obese class I, obese class II, and obese class III subjects. None of the demographic, anthropometric, and biochemical variables (except low-density lipoprotein cholesterol) correlated with 25(OH)D levels. Conclusions: The prevalence of vitamin D deficiency in overweight and obese Bangladeshi adults is very high.

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Prevalence of 25-hydroxy vitamin D deficiency among type 2 diabetic subjects of South India

Cited by 8 publications

References 17 publications

The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya

The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

Vitamin D status of overweight and obese Bangladeshi adults

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