Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Abstract

Objectives To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Methods Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren–Lawrence grade (KLG)≥2, erosive HOA as KLG≥2 plus erosion and symptomatic HOA as KLG≥2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as ≥1 affected joint. The prevalence was age-standardised (US 2000 Population 40–84 years). Results Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly higher in women (44.2%) than men (37.7%), whereas the age-standardised prevalence of erosive and symptomatic OA was much higher in women (9.9% vs 3.3%, and 15.9% vs 8.2%). The crude incidence of HOA over 9-year follow-up was similar in women (34.6%) and men (33.7%), whereas the majority of those women (96.4%) and men (91.4%) with HOA at baseline showed progression during follow-up. Incident metacarpophalangeal and wrist OA were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive HOA at baseline (as opposed to those without HOA), and was more frequent in women (17.3%) than men (9.6%). Conclusions The usual female predominance of prevalent and incident HOA was less clear for radiographic HOA than for symptomatic and erosive HOA. With an ageing population, the impact of HOA will further increase.

Approach to hand osteoarthritis

“…[74,75] Daha yüksek prevalans oranlar› 2011 y›l›nda yap›lan Framingham çal›flmas›n-da bildirilmifl olup 40-80 yafl aras› yetiflkinlerde prevalans erkekler için %3.3, kad›nlar için %9.9 olarak bulunmufltur. [76] EOA kad›nlar› erkeklerden daha çok etkilemeye meyillidir; fakat Rotterdam çal›flmas›nda erkek ve kad›nlar aras›nda belirgin bir fark saptanmam›flt›r. [73] Eroziv lezyonlar bask›n olarak D‹F eklemlerde olup, daha az olarak da P‹F'lerde izlenmektedir.…”

“…[73] Eroziv lezyonlar bask›n olarak D‹F eklemlerde olup, daha az olarak da P‹F'lerde izlenmektedir. [76,77] Crain ve ark. daha önce EO-A'n›n kal›tsal oldu¤unu ileri sürmüfltür.…”

Biomechanical evaluation of pyrocarbon proximal interphalangeal joint arthroplasty: An in-vitro analysis

“…The proximal interphalangeal (PIP) joint is the third most common site of osteoarthritis in the hand (Drake and Segalman, 2010;Haugen et al, 2011). Pinch and grip strength may be substantially reduced as a consequence of pain or limited mobility in this joint.…”

In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography

“…At the age of 60 years, hand OA is prevalent in about 40% of people. 1 The first carpometacarpal joint (CMC-1) is the second most frequent location of hand OA 2 and a major cause for pain and disability in patients suffering from OA. 3 The hallmark feature of OA is degeneration of articular cartilage that lines the synovial joints, with accompanying inflammatory reaction of the synovial membrane and underlying bone.…”