Prevalence, Incidence and Persistence of EB Virus Antibody in Young Adults

Niederman, James C.; Evans, Alfred S.; Subrahmanyan, L.; McCollum, Robert W.

doi:10.1056/nejm197002122820704

Cited by 257 publications

(81 citation statements)

References 15 publications

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“…The majority of the human population undergo subclinical infection with EBV during childhood (Niederman et al, 1970), and the virus then establishes a lifelong persistent infection in two cellular sites -squamous epithelial cells and B lymphocytes (Sixbey, 1989). Virus replication in oropharyngeal epithelium accounts for spread of the virus between individuals, and latent infection of B lymphocytes establishes persistence.…”

Section: Introductionmentioning

confidence: 99%

Non-correlation of in vivo and in vitro parameters of Epstein-Barr virus persistence suggests heterogeneity of B cell infection.

Johannessen

Haque²,

Njie-Jobe³

et al. 1998

Journal of General Virology

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Section: Introductionmentioning

confidence: 99%

Non-correlation of in vivo and in vitro parameters of Epstein-Barr virus persistence suggests heterogeneity of B cell infection.

Johannessen

Haque²,

Njie-Jobe³

et al. 1998

Journal of General Virology

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“…Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus: approximately 90% of the adult population worldwide is infected (Niederman et al, 1970). Primary infection is usually asymptomatic; however, in some individuals, usually adolescents, it can cause infectious mononucleosis (Henle et al, 1968).…”

Section: Introductionmentioning

confidence: 99%

Identification of an epithelial cell differentiation responsive region within the BZLF1 promoter of the Epstein--Barr virus

Karimi

Crawford

Speck

et al. 1995

Journal of General Virology

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The Epstein-Barr virus (EBV) BZLF1 gene product, Zta is able to trigger the viral lyric cycle in latently infected B lymphocytes. Investigations into regulation of the promoter, Zp for the BZLF1 gene in B cells have identified 12-O-tetradecanoylphorbol 13-acetate, antiimmunoglobulin and Zta responsive elements as well as a negative regulatory element within Zp. EBV infects and replicates within squamous epithelial cells and there is evidence to indicate that EBV gene expression is linked to the differentiation status of epithelial cells. We have investigated regulation of Zp in undifferentiated and differentiated cells of the human squamous epithelial cell line SCC12F. Zp was found to be active in SCC12F cells and activity was increased approximately 7-fold upon induction of epithelial terminal differentiation. Sequences responsive to epithelial cell differentiation were contained within the region of Zp from -86 to + 12 bp, a region previously shown to contain an AP-1-like binding site, designated the ZII domain. In addition, enhancing sequences were detected in the region -221 to -86bp. These studies will lead to a greater understanding of differentiation-linked EBV gene expression in human squamous epithelial cells.

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“…Serological studies have shown that EBV is broadly disseminated in all human populations studied (Hinuma, Ohta-Hatano, Suto & Numazaki, 1969;Porter, Wimberley & Benyesh-Melnick, 1969;Niederman, Evans, Subrahmanyan & McCollum, 1970) than the general population. In a prospective study, Evans & Niederman (1972) reported that 5.5 % of EBV-seronegative subjects developed clinical infectious mononucleosis and became seropositive within 1 year.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological studies of Epstein–Barr herpesvirus infection in Western Australia

Lai¹,

Mackay‐Scollay²,

Alpers

1975

J. Hyg.

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SUMMARYIn a study on a Caucasian population in Western Australia the prevalence of antibodies to Epstein-Barr virus (EBV) was 41 % in the 9-to 10-year age group, 80 % in the 16 to 19-year age group and 92 % in young adults. The age-specific annual seroconversion rates indicated two peaks of primary EBV infection in the population studied -one under 5 years of age and the other at adolescence. The geometric mean titre rose with age, from 23 at 5-6 years to 53 at 36-40 years.It was shown that in 73 families studied there was evidence of probable spread of EBV infection among siblings, particularly between those of the same sex.Serological study of patients with infectious mononucleosis indicated that 100 % of those examined had antibody to EBV and the geometric mean titre was elevated to 210. Rising titres and seroconversion was demonstrated in these patients together with successful establishment of EBV-carrying cell lines from the peripheral blood in two-thirds of the cases.

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Prevalence, Incidence and Persistence of EB Virus Antibody in Young Adults

Cited by 257 publications

References 15 publications

Non-correlation of in vivo and in vitro parameters of Epstein-Barr virus persistence suggests heterogeneity of B cell infection.

Non-correlation of in vivo and in vitro parameters of Epstein-Barr virus persistence suggests heterogeneity of B cell infection.

Identification of an epithelial cell differentiation responsive region within the BZLF1 promoter of the Epstein--Barr virus

Epidemiological studies of Epstein–Barr herpesvirus infection in Western Australia

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