Prevalence, Impact, and Predictive Value of Detecting Subclinical Coronary and Carotid Atherosclerosis in Asymptomatic Adults

Abstract

Detection of subclinical carotid or coronary atherosclerosis improves risk predictions and reclassification compared with conventional risk factors, with comparable results for either modality. Cost-effective analyses are warranted to define the optimal roles of these complementary techniques. (BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population; NCT00738725).

Coronary artery calcification in clinical practice: what we have learned and why should it routinely be reported on chest CT?

“…The BioImage study (a clinical study of burden of atherosclerotic disease in an at-risk population): prevalence, impact, and predictive value of detecting subclinical coronary and carotid AS in asymptomatic adults (44). That study demonstrated that detection of subclinical carotid or coronary AS improves risk predictions and reclassification compared with conventional risk factors.…”

New Insights into Dialysis Vascular Access: Molecular Targets in Arteriovenous Fistula and Arteriovenous Graft Failure and Their Potential to Improve Vascular Access Outcomes

“…High-frequency ultrasound technology has been used in several small studies to evaluate serial intima-medial changes and biomechanics in AVF development (67,68) in the clinical setting and has the potential to serve as a technology to evaluate serial neointimal hyperplasia development and elasticity in a developing AVF. Finally, three-dimensional ultrasonography, which has been used in other fields of vascular disease (69,70) (e.g., carotid atherosclerosis), could also provide a noninvasive method to assess hemodynamic and pathologic changes in AVF development and is potentially translatable to clinical care settings.…”

Brachial-ankle pulse wave velocity is associated with composite carotid and coronary atherosclerosis in a middle-aged asymptomatic population

“…At least 10%-15% of subjects with overt coronary heart disease have no major risk factors 28) . Previous observational cohort studies for primary prevention showed varied prevalence (ranged from 40% to 90%) of subclinical atherosclerosis depending on the definition [29][30][31] . This study adopted more stringent definitions of subclinical atherosclerosis compared with previous studies, and the composite prevalence of both coronary and carotid atherosclerosis was 28.2%.…”