Prevalence, genotype diversity and determinants of anal HPV infection in HIV-uninfected men having sex with men

Donà, Maria Gabriella; Palamara, Guido; Carlo, Aldo Di; Latini, Alessandra; Vocaturo, Amina; Benevolo, Maria; Pimpinelli, Fulvia; Giglio, A.; Moretto, Domenico; Impara, Giampaolo

doi:10.1016/j.jcv.2012.02.014

Cited by 54 publications

(54 citation statements)

References 25 publications

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“…26 However, some authors have also reported higher risk of HPV infection (but not visible anogenital warts) among MSM with lower education levels. 27 Contrary to studies reporting an increased presence of HPV in those practicing receptive anal intercourse, 24,27 reporting a receptive role during anal intercourse in the present study was associated with a 57% reduction in risk for having anogenital warts compared with only/mostly insertive anal intercourse. This finding is interesting in the context of research identifying the anal canal as an HPV reservoir.…”

Section: Discussioncontrasting

confidence: 89%

“…This could be due to several factors including improved safe-sex education among younger MSM, lower frequency of anal intercourse acts among those younger than 14 years compared with older MSM, or the development of HPV-specific immunity due to early exposure among those with earlier sexual debut. 27 However, evidence for strong, lifelong natural immunity to infection has not been established. 29 The univariate analysis findings that engaging in transactional sex and self-identifying as a transwoman were significantly associated with a lower risk of anogenital warts could be related to greater awareness of anogenital warts in these groups.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Factors Associated With Visible Anogenital Warts Among HIV-Uninfected Peruvian Men Who Have Sex With Men and Transwomen

Galea¹,

Kinsler

Galan

et al. 2015

Sexually Transmitted Diseases

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Factors Associated With Visible Anogenital Warts Among HIV-Uninfected Peruvian Men Who Have Sex With Men and Transwomen

Galea¹,

Kinsler

Galan

et al. 2015

Sexually Transmitted Diseases

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“…The population at the highest risk of developing anal cancer includes HIV-infected subjects, males who have sex with males and transplant recipients [2][3][4][5][6]. Despite this fact, a still significant proportion of anal cancers are detected in generally healthy and HIV-negative subjects.…”

Section: Abstract: Anal Cancer Cervical Intraepithelial Neoplasia mentioning

confidence: 99%

Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion

Sláma¹,

Sehnal²,

Dušek³

et al. 2015

neo

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The aim of our study was to determine the risk factors associated with anal HPV infection in HIV-negative women with high-grade cervical lesion. The study group included 172 "high-risk" women who underwent conization for high-grade cervical intraepithelial lesion or microinvasive cervical cancer (CIN 2+). The control group consisted of 100 "low-risk" women with non-neoplastic gynecologic diseases. All participants completed a questionnaire detailing medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping. Concurrent cervical and anal HPV infections were detected in 42.4% (73/172) women of the study group, and in 8.0% (8/100) of women in the control group, respectively. The subgroup with concurrent HPV infections (n=73) dominated women with CIN 3 and microinvasive cancer and anal HPV 16 infections (n=53). Women with concurrent infections more frequently reported any type of sexual contact with the anus including non-penetrative anal sex (OR 2.62, p=0.008). Reporting >5 lifetime sexual partners (OR 2.43, p=0.041), smoking > 60 cigarettes per week (OR 2.33, p=0.048), and a history of penetrative anal intercourse (OR 3.87, p=0.002) were observed as the significant risk factors in women with multiple concurrent HPV infections. Our data support anal HPV testing and anal Pap smear screening in all women with severe cervical lesions caused by HPV 16 and a history of any sexual contact with the anus, heavy smoking and/or more than 5 lifetime sexual partners. Key words: anal cancer, cervical intraepithelial neoplasia, HPV, risk factorAnal cancer is an uncommon disease, but its incidence has grown during the last decades in most developed countries [1]. The population at the highest risk of developing anal cancer includes HIV-infected subjects, males who have sex with males and transplant recipients [2][3][4][5][6]. Despite this fact, a still significant proportion of anal cancers are detected in generally healthy and HIV-negative subjects. Moreover, anal cancers are more frequently detected in women than in men [7]. In the U.S., invasive anal squamous cell carcinoma rates increased among females by 1.7 % per year between 1973 and 2005 [1]. In 2012 there were an estimated 6230 new cases of anal cancer in the U.S., with 3980 (63.9 %) cases occurring in women and only 2250 (36.1 %) cases in men [8]. Similarly, in the Czech Republic the prevalence of anal cancer is constantly higher among women than in men. In 2010 there were 129 new cases of anal cancer, with 85 (65.9 %) cases in women and 44 (34.1 %) cases in men.This gender difference is not clearly explained. Since more than 90 % of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection [9], possible reasons for the greater risk in women include history of cervical intraepithelial neoplasia (CIN) and cervical cancer [10][11][12]. The only two studies dealing with women with lower genital tract intraepithelial lesions or cancers which also looked at anal HPV showed 45 -51 % HPV prevalence in this group [13,14]. ...

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“…While studies of anal HPV among heterosexual men observe a prevalence of approximately 12% [43], studies among MSMs indicate that it is much more common with half or more of HIV-negative MSMs having anal infection depending on the population sample [43,[49][50][51]. A recent meta-analysis estimated the prevalence of HPV-16 at the anal canal among HIV-negative MSMs to be 12.5% [51].…”

Section: Anal Infection and Associated Factorsmentioning

confidence: 99%

The Epidemiology of Human Papillomaviruses

Nyitray¹,

Iannacone²

2014

Human Papillomavirus

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Epidemiological studies indicate that most men and women will acquire a sexually transmitted anogenital human papillomavirus (HPV) infection in their lifetimes. In addition, infection with cutaneous HPV types is essentially ubiquitous. Most HPV infections are transient with no clinical symptoms although a minority of infections result in clinical disease such as warts or malignancies. Anogenital warts are the most common clinical manifestation of HPV infection with a prevalence of perhaps 1%. Virtually 100% of cervical cancers, 90-93% of anal canal cancers, 12-63% of oropharyngeal cancers, 36-40% of penile cancers, 40-64% of vaginal cancers and 40-51% of vulvar cancers are attributable to HPV infection. Of the estimated 12.7 million cancers occurring globally in 2008, 610,000 (approx. 5%) were HPV-associated anogenital or oral cancers. Cutaneous HPV types may increase the risk for nonmelanoma skin cancers. Sexual behavior is a primary risk factor associated with anogenital and oral HPV infection among men and women.

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Prevalence, genotype diversity and determinants of anal HPV infection in HIV-uninfected men having sex with men

Cited by 54 publications

References 25 publications

Factors Associated With Visible Anogenital Warts Among HIV-Uninfected Peruvian Men Who Have Sex With Men and Transwomen

Factors Associated With Visible Anogenital Warts Among HIV-Uninfected Peruvian Men Who Have Sex With Men and Transwomen

Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion

The Epidemiology of Human Papillomaviruses

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