Prevalence, etiology, and clinical implications of reduced longitudinal systolic strain in renal transplant candidates

Rhea, Isaac; Morris, Donald; Sawada, Stephen; Feigenbaum, Harvey

doi:10.1111/echo.13307

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…Strain imaging is increasingly used for assessment of subclinical cardiac dysfunction in various patient populations. [74][75][76] There has also been an emerging role for strain imaging in quantifying and identifying regions of diastolic function in the myocardium. 77 Measure of strain by ultrasonography is thought to be a surrogate measure of deformation, and strain rate is a surrogate measure of rate of deformation.…”

Section: Refined Algorithms For Distinction Of Pre-and Post-capillarymentioning

confidence: 99%

“…Strain imaging is increasingly used for assessment of subclinical cardiac dysfunction in various patient populations 74 – 76 . There has also been an emerging role for strain imaging in quantifying and identifying regions of diastolic function in the myocardium 77 .…”

Section: Emerging Modalities For Assessment Of Diastolic Function: Strain Imaging and Diastolic Stress Testingmentioning

confidence: 99%

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Echocardiographic evaluation of diastolic function in the setting of pulmonary hypertension

2019

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Heart failure due to diastolic dysfunction and pulmonary hypertension are frequent comorbid conditions with significant morbidity and mortality. Identifying the presence and etiology of diastolic dysfunction in the setting of pulmonary hypertension remains challenging despite profound therapeutic and prognostic implications. Additionally, there is little guidance in identifying and parsing etiology of diastolic dysfunction in patients found to have pulmonary hypertension. This review discusses the complex interplay between left ventricular diastolic dysfunction and pulmonary hypertension. With an explicit focus on the use of echocardiography for determination of diastolic dysfunction and etiology of pulmonary hypertension, this review also provides a comprehensive review of the literature and provides a framework by which to assess diastolic dysfunction echocardiographically in the setting of pulmonary hypertension.

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Section: Refined Algorithms For Distinction Of Pre-and Post-capillarymentioning

confidence: 99%

Section: Emerging Modalities For Assessment Of Diastolic Function: Strain Imaging and Diastolic Stress Testingmentioning

confidence: 99%

Echocardiographic evaluation of diastolic function in the setting of pulmonary hypertension

2019

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“…Previous studies have also shown that MW is superior to GLS in predicting outcomes and detecting coronary heart disease and may find subclinical disorders that GLS cannot show (17,31,32). Furthermore, previous studies have considered patients with absolute GLS values <18% to have LV systolic insufficiency (33)(34)(35). In this regard, we performed further analysis: we divided SLE patients into ≥18% and <18% groups and found that the differences in GWE and GWW were statistically significant from the normal group regardless of whether GLS was impaired in SLE patients, and were more pronounced in those with <18%, which suggested that PSL parameters may be able to detect subclinical myocardial damage earlier than current methods (Table 6).…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of left ventricular systolic function in patients with systemic lupus erythematosus: a non-invasive pressure-strain loop technique

Li¹,

Chen²,

Han³

et al. 2022

Quant Imaging Med Surg

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Background: Systemic lupus erythematosus (SLE) is associated with a variety of cardiovascular diseases, even in the early stage of disease development. The purpose of this study was to quantitatively evaluate left ventricular (LV) systolic function in patients with SLE using a novel non-invasive pressure-strain loop (PSL) technique.Methods: This prospective case-control study included 132 patients with SLE and 99 normal controls, all of whom underwent traditional transthoracic echocardiography. The LV myocardial work was evaluated with the PSL technique based on speckle tracking and brachial artery blood pressure. The differences among groups were compared, and the correlations between myocardial work, laboratory data, and disease activity were analyzed in the SLE group. Results: Compared with the normal group, SLE patients had significantly higher global wasted work {GWW; SLE: 109 [82-150] mmHg%; controls: 66 [45-109] mmHg%; P<0.001} and impaired global work efficiency [GWE; SLE: 95% (94-97%); controls: 97% (96-98%); P<0.001]. Global work index (GWI) and global constructive work (GCW) did not show significant differences (P>0.05). Further subdivision analysis found that the increase of GWW and the damage of GWE were more obvious in SLE patients with high disease activity or severe diastolic dysfunction. Multivariate analysis revealed that increased erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-phospholipid antibodies, peak strain dispersion, and SLE Disease Activity Index (SLEDAI) were independently associated with increased GWW (β=0.189, 0.230, 0.444, 0.111, and 0.180, respectively; all P<0.05) and damaged GWE (β=−0.184, −0.130, −0.468, −0.149, and −0.191, respectively; all P<0.05). Conclusions: The non-invasive PSL can quantitatively evaluate the LV systolic function in SLE patients.This technique may provide a new method for monitoring cardiac function in chronic diseases.

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“…Participants were excluded if there was any suboptimal segment. As previously reported, a GLS absolute value of <18% was considered subclinical LV systolic dysfunction in participants with preserved LVEF, according to previous researches (9,12,15).…”

Section: D Stimentioning

confidence: 99%

Frequency and risk factors of impaired left ventricular global longitudinal strain in patients with end-stage renal disease: a two-dimensional speckle-tracking echocardiographic study

Liu¹,

Wang²,

Liú³

et al. 2021

Quant Imaging Med Surg

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Background: It has been identified that two-dimensional speckle-tracking imaging (2D-STI) enables the early detection of left ventricular (LV) systolic dysfunction. This study's objective was to evaluate the frequency of impaired LV global longitudinal strain (GLS) and investigate the factors in end-stage renal disease (ESRD) patients with preserved LV ejection fraction (LVEF) associated with the impaired GLS.Methods: A total of 100 ESRD patients with preserved LVEF who underwent transthoracic echocardiography (TTE) were studied. The GLS was calculated as the average of peak longitudinal strain from 18 myocardial segments obtained utilizing the three-standard apical imagings. According to a predefined cutoff, a GLS absolute value of less than 18% was considered subclinical LV systolic dysfunction.Results: Impaired LV GLS <18% was detected in 58 participants (58/100, 58%). Multivariate analysis exhibited that increased LV mass index was independently associated with impaired GLS <18% [odds ratio (OR): 1.028, 95% confidence interval (CI): 1.004-1.052, P=0.020]. For sequential logistic regression models, model 1, based on parameters included in multivariate logistic regression (χ 2 =30.0), was improved by the addition of the LV mass index (χ 2 =37.4, P<0.01). Conclusions:The frequency of impaired LV GLS in ESRD patients with preserved LVEF was relatively high. An increased LVEF was independently associated with impaired LV GLS.

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Prevalence, etiology, and clinical implications of reduced longitudinal systolic strain in renal transplant candidates

Abstract: Clinical variables and co-findings beyond EF are associated with abnormal strain measurements and may partially explain the large incidence of abnormal strain in renal transplant candidates.

Cited by 7 publications

References 38 publications

Echocardiographic evaluation of diastolic function in the setting of pulmonary hypertension

Echocardiographic evaluation of diastolic function in the setting of pulmonary hypertension

Quantitative assessment of left ventricular systolic function in patients with systemic lupus erythematosus: a non-invasive pressure-strain loop technique

Frequency and risk factors of impaired left ventricular global longitudinal strain in patients with end-stage renal disease: a two-dimensional speckle-tracking echocardiographic study

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