Prevalence, Etiology, and Associated Symptoms of Vaginal Discharge During Pregnancy in Women Seen in a Tertiary Care Hospital in Bihar

Prasad, Dipali; Parween, Sadia; Kumari, Kanchan; Singh, Neelima

doi:10.7759/cureus.12700

Cited by 10 publications

(10 citation statements)

References 11 publications

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“…AV is characterized by a sharply reduced lactobacilli level, high levels of aerobic bacteria, including Streptococcus agalactiae , Staphylococcus aureus , Escherichia coli , and Enterococcus faecalis , and vaginal inflammation ( Prasad et al., 2021 ; Wójkowska-Mach et al., 2021 ). Antibiotics that target aerobic bacteria such as clindamycin, meclocycline, and kanamycin have been used to treat AV ( Ma et al., 2022 ).…”

Section: Probiotic Lactobacilli In the Treatment Of Vaginal Infectionsmentioning

confidence: 99%

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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The vaginal microbiome is a distinct component of the human microbiome that is colonized by a wide variety of microorganisms. Lactobacilli are the most frequently identified microorganisms in the healthy human vagina. These Gram-positive bacilli can acidify the vaginal microenvironment, inhibit the proliferation of other pathogenic microorganisms, and promote the maintenance of a eubiotic vaginal microbiome. However, a vaginal flora with a reduced proportion or abundance of lactobacilli is associated with various vaginal infections that have been linked to serious health consequences such as infertility, preterm birth, pelvic inflammatory disease, premature rupture of membranes, and miscarriage. Due to their “Generally Recognized as Safe” classification and critical role in vaginal health, probiotic lactobacilli have been widely used as an alternative or adjunct to traditional antibiotic therapy for the treatment of vaginal infections and restoration of the vaginal microbiome. This review focuses on the significant role of probiotic lactobacilli in the vaginal microenvironment and discusses the use of probiotic lactobacilli in the treatment of female vaginal infections in vitro and in vivo.

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Section: Probiotic Lactobacilli In the Treatment Of Vaginal Infectionsmentioning

confidence: 99%

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Os sintomas mais comuns de candidíase são corrimento vaginal branco, grumoso, espesso, inodoro, que aderem à vagina, eritema, edema e fissuras vulvares (ROSSI et al, 2017;ÁGUAS;SILVA, 2012). A candidíase foi considerada a causa mais comum de corrimento vaginal patológico, segundo um estudo transversal feito em um hospital no oeste da Índia, onde descobriu-se que 183 (78,54%) das mulheres gestantes que tiveram Brazilian Journal of Development, Curitiba, v.7, n.12, p. 121590-121610 dec. 2021 corrimento vaginal, o diagnóstico clínico mais frequente foi C. albicans (PRASAD, 2021).…”

Section: Candidíase Vulvovaginal E Gravidezunclassified

Fatores de virulência de candidíase em mulheres grávidas: uma revisão de literatura / Candidiasis virulence factors in pregnant women: a literature review

Silva¹,

Oliveira²,

Pessoa³

et al. 2022

BJDV

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RESUMOA candidíase vulvovaginal (CVV) é uma doença onde se encontra uma infeção da vulva e da vagina, causada pelo gênero Candida spp.. Possui mais de 200 tipos de diferentes microrganismos, dos quais a Candida albicans se destaca mais em função de sua taxa de prevalência em condições normais e de infecção. Nessa perspectiva, este estudo buscou realizar uma revisão de literatura sobre os fatores de virulência de candidíase em mulheres grávidas. O presente estudo se caracteriza como um tipo de revisão bibliográfica, exploratória e descritiva. Os trabalhos selecionados foram incluídos a partir de base de dados Scientific Eletronic Library Online (SCIELO) e no PubMed, o período de busca foram os anos de 2015 a 2021. Os descritores utilizados para a busca de estudos foram: "candidíase", "Candida", "Candida albicans", "candidíase vulvovaginal", "gravidez", "vulvovaginal candidiasis", "pregnancy and predisposing factors". Observou-se que a candidíase vaginal é das maiores ocorrências relacionadas a infeções genitais e, na maioria das vezes, é uma doença primária, ou seja, surge em função de algum desequilíbrio da microbiota vaginal normal da paciente ou até mesmo alterações no seu estado imunológico. Desse modo, em função da diversidade de formas e métodos de resistência é preciso uma atualização dos tratamentos, realização de campanhas para conscientização e esclarecimentos, na busca por novos alvos terapêuticos, e estratégias de prevenção e diagnóstico destas infeções principalmente ao que se refere a mulheres gestantes.

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“…48,50,[54][55][56][57][58][59][60] Klebsiella pneumoniae was examined in 12. 48,50,[54][55][56][58][59][60][61][62] Pseudomonas spp. in 7, 34,48,54,55,58,61 Enterobacter spp.…”

Section: Prevalence Of Gram-negative Bacteriamentioning

confidence: 99%

Prevalence of Gram-negative Bacteria in Maternal Cervical Secretions: A Systematic Review and Meta-analysis

Maheshwari¹,

Sah²,

Kumar³

et al. 2022

Newborn

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Background:In neonates, early-onset sepsis (EOS) occurring within 72 hours after birth is an important cause of mortality worldwide. Emerging data show that EOS may occur more frequently in tropical and peri-equatorial regions with more gram-negative bacteria than in the Western countries. This systematic review aimed to estimate the prevalence of gram-negative bacteria in the maternal genital tract during the peripartum period. Materials and methods: We explored the primary research studies that reported the presence of gram-negative bacteria in the maternal genital tract using the software STATA, version 17.1. Five databases, PubMed, Embase, Scopus, Web of Science, and ProQuest were searched until October 2022. Data were analyzed using random-effects meta-analyses to determine the prevalence of gram-negative bacteria in the maternal genital tract. Results: Fifteen studies qualified for analysis by our predetermined inclusion criteria. The overall prevalence of gram-negative bacteria in cervical secretions was 23.20% (95% CI [confidence interval]: 11.77-37.08, I 2 : 99.79%). Escherichia coli (15.3%) and Acinetobacter (0.36%) species reported the highest and lowest prevalent bacteria, respectively. The prevalence of other gram-negative species was Klebsiella pneumoniae (0.47%), Pseudomonas (2.81%), Enterobacter (3.33%), Alcaligenes faecalis (1.32%), Proteus vulgaris (10.0%), and Providencia alcalifaciens (10%). Most of the studies were from tropical countries, and there was a positive linear relationship between the studies. Conclusion: Gram-negative colonization of the maternal cervical-vaginal tract may be more frequent than previously recognized in tropical/periequatorial regions of the world. Early identification of these bacterial pathogens may help in timely evaluation and treatment of these infants.

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Prevalence, Etiology, and Associated Symptoms of Vaginal Discharge During Pregnancy in Women Seen in a Tertiary Care Hospital in Bihar

Cited by 10 publications

References 11 publications

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Fatores de virulência de candidíase em mulheres grávidas: uma revisão de literatura / Candidiasis virulence factors in pregnant women: a literature review

Prevalence of Gram-negative Bacteria in Maternal Cervical Secretions: A Systematic Review and Meta-analysis

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