Prevalence Estimation of Dementia in a Rural Area of Korea

Woo, Jong Inn; Lee, Jung Hie; Yoo, Keun-Young; Kim, Chang-Yup; Kim, Yong-Ik; Shin, Yang Sik

doi:10.1111/j.1532-5415.1998.tb02753.x

Cited by 61 publications

(44 citation statements)

References 31 publications

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“…Consistent with earlier prevalence studies in Korea [2,3,10,11] and other countries [1] , we found that the rate of dementia increased exponentially with age. The agestandardized prevalence rate of dementia and its subtypes in the Korean population of 2005 was 6.3%, which is likely to increase since the Korean society is rapidly transforming from an aging society to an aged society.…”

Section: Discussionsupporting

confidence: 81%

“…In Korean elders, the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) has been estimated to range from 4.2 to 6.5% and 1.3 to 2.5%, respectively [3,[9][10][11] . However, although dementia with Lewy bodies (DLB) has been suggested to be the second most common type of degenerative dementia in older people [12] , the prevalence of DLB has never been investigated in Korea.…”

Section: Prevalence Of Dementia In Korean Eldersmentioning

confidence: 99%

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Prevalence of Dementia and Its Subtypes in an Elderly Urban Korean Population: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

Jhoo

Kim

Huh

et al. 2008

Dement Geriatr Cogn Disord

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Background/Aims: We estimated the prevalence of dementia and its major subtypes in an elderly urban Korean population. Methods: A study population of 1,118 Korean elders was randomly sampled from the residents aged 65 years or older living in Seongnam, Korea. Standardized face-to-face interviews, and neurological and physical examinations were conducted on 714 respondents. Dementia was diagnosed according to the DSM-IV diagnostic criteria, and its subtypes were determined according to the criteria of the NINCDS-ADRDA, the NINDS-AIREN, and the consensus guideline proposed by McKeith et al. [Neurology 1996;47:1113–1124]. Results: The estimated age- and gender-standardized prevalences were 6.3% for dementia (95% CI = 4.5–8.1), 4.8% for Alzheimer’s disease (AD; 95% CI = 3.3–6.4), 1.0% for vascular dementia (VD; 95% CI = 0.3–1.8), and 0.4% for dementia with Lewy bodies (DLB; 95% CI = 0.0–0.9). The prevalence of AD consistently increased with age, whereas that of VD peaked at age 75–79 years and decreased thereafter. Of the dementia patients, 72.0% were in the very mild or mild stages of the disease. Conclusions: The prevalence of dementia in a typical urban area of Korea was estimated to be 6.3%, and AD was the most prevalent subtype. DLB was less prevalent than VD among these community-dwelling Korean elders.

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Section: Discussionsupporting

confidence: 81%

Section: Prevalence Of Dementia In Korean Eldersmentioning

confidence: 99%

Prevalence of Dementia and Its Subtypes in an Elderly Urban Korean Population: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

Jhoo

Kim

Huh

et al. 2008

Dement Geriatr Cogn Disord

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“…In Japan, 18.2% of residents aged 60 years or older in a remote island in Kagoshima (Kodama et al, 2002) and 21.8% of Tajiri rural residents aged 65 years or older (Ishizaki et al, 1998) showed an MMSE score less than 24. In a study of Korean community-dwelling elderly aged 65 or older, the reported prevalence was much higher at 33.7% for rural residents (Woo et al, 1998) and 29.3% for urban residents . The prevalence of depressive symptoms, screened using the GDS, was reported to be 30.2% for the urban elderly and 24.9% for the rural elderly in Japan (Niino et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan

Lee

Shinkai

2005

Int J Geriat Psychiatry

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SUMMARYBackground Cognitive impairment and depressive symptoms impose a heavy burden on the care of the elderly in Japan and Korea, two of the fastest aging nations in Asia. The purpose of this study was to examine and compare factors associated with cognitive impairment and depressive symptoms among older persons in the two countries. Methods In 2002, representative samples of community-dwelling people aged 65 and older were selected among residents in Anyang, Korea and Yoita, Japan. Mini-Mental State Examination and Geriatric Depression Scale were used to assess the elderly's mental status. Sociodemographics, physical function, chronic conditions, social support, and health behaviors were examined to identify significant associations. Results The prevalence of cognitive impairment in older adults was 17.0% in Anyang and 14.6% in Yoita. The rates for depressive symptoms were 15.2% and 19.8%, respectively. Overall, functional capacity was the universal factor significantly associated with mental conditions. Self-rated health and social support were also found to be independently associated with depressive symptoms in the study subjects. Differences in the patterns of association by community, however, were notable for other characteristics. For example, in factors associated with cognitive impairment, sociodemographic factors such as age, gender, and education were significant among Koreans, whereas socio-behavioral factors such as obesity, social support and hospitalization experience were found to be significant for older Japanese residents. Conclusions Similarities in the patterns of association indicate the need for joint explorations into the role these factors play in affecting the mental health of older persons. Socioeconomic and regional differentials, however, may account for the disparity in the associations observed, suggesting the importance of developing mental health programs sensitive to the older individual's culture.

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“…MVD also determines volume of possible binding site before docking and cavity with largest volume is selected as docking point. Population of Indian subcontinent has very low risk of AD as compared to other continent of the world (Boersma et al 1998;Brayne et al 1998;Azzimondi et al 1998;Shaji et al 1996;Yamada et al 1999;Woo et al 1998;Lin et al 1998;Fillenbaum et al 1998;Herrera et al 1998;Lopes et al 2007). This may be due to regular consumption of curry spice turmeric and other herbal congeners by Indian population.…”

Section: Structural Conservation Of B-amentioning

confidence: 99%

Comparative docking and ADMET study of some curcumin derivatives and herbal congeners targeting β-amyloid

Singh

Gupta

Kesharwani

et al. 2013

Netw Model Anal Health Inform Bioinforma

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Alzheimer's disease (AD) is caused by the accumulation of beta-amyloid (b-A) in the brain that forms amyloid plaque. b-A is an oligo-peptide consisting of 39-42 amino acid residues, produced by proteolytic cleavage of amyloid precursor protein by secretase enzymes. Evolutionary trace and protein family analysis of b-A indicates that C-terminal residues of b-A are highly conserved and hydrophobic in nature. Prevalence of hydrophobic residues at C-terminal of b-A promote aggregation, and also provide the stability to b-A plaque due to hydrophobic-hydrophobic interaction between residues of b-A. In this work, designing, evaluation and screening of potent inhibitors for b-A formation were studied. Curcumin and some of its herbal congeners were taken into consideration, to evaluate their anti-alzheimeric property against b-A as well as with b-A fibrils. Most of these herbal compounds were found potent inhibitors of b-A aggregation than known drugs for AD. The binding affinity of cassumunins A and B was compared with that of curcumin and it was found that cassumunins A and B may cause more potent inhibition of b-A than curcumin. Principal descriptors as well as absorption, distribution, metabolism, excretion and toxicity (ADMET) properties for these compounds were predicted, and were found satisfactory.

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Prevalence Estimation of Dementia in a Rural Area of Korea

Abstract: These results showed that the prevalence of dementia in Korea was similar to its presence in Western countries but different from that previously reported in other Asian countries, e.g., China and Japan.

Cited by 61 publications

References 31 publications

Prevalence of Dementia and Its Subtypes in an Elderly Urban Korean Population: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

Prevalence of Dementia and Its Subtypes in an Elderly Urban Korean Population: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan

Comparative docking and ADMET study of some curcumin derivatives and herbal congeners targeting β-amyloid

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