Prevalence estimates for MS in the United States and evidence of an increasing trend for women

Noonan, Curtis W.; Kathman, Steven J.; White, Mary C.

doi:10.1212/wnl.58.1.136

Cited by 185 publications

(131 citation statements)

References 15 publications

(9 reference statements)

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“…27 However, a larger sample should be studied to verify whether the difference is real or just occurred by chance. A variety of infectious agents have been postulated as important in the etiology of multiple sclerosis, but a causal association has not been demonstrated convincingly for any infectious agent.…”

Section: Commentmentioning

confidence: 99%

“…A variety of infectious agents have been postulated as important in the etiology of multiple sclerosis, but a causal association has not been demonstrated convincingly for any infectious agent. [26][27][28][29] An increased risk for multiple sclerosis is likely to involve a combination of genetic susceptibility and environmental exposures. 30 In addition, a clustering of multiple sclerosis in Galion, OH, from 1982 to 1985 was attributed to an excess concentration of heavymetal wastes, especially cadmium and chromium, in sewage and river water.…”

Section: Commentmentioning

confidence: 99%

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Health Survey of Residents Living Near Farm Fields Permitted to Receive Biosolids

Khuder

Milz

Bisesi

et al. 2007

Archives of Environmental & Occupational Health

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The authors studied the health status of residents living in Wood County, OH, near farm fields that were permitted to receive biosolids. They mailed a health survey to 607 households and received completed surveys from 437 people exposed to biosolids (living on or within 1 mile of the fields where application was permitted) and from 176 people not exposed to biosolids (living more than 1 mile from the fields where application was permitted). The authors allowed for up to 6 surveys per household. Results revealed that some reported health-related symptoms were statistically significantly elevated among the exposed residents, including excessive secretion of tears, abdominal bloating, jaundice, skin ulcer, dehydration, weight loss, and general weakness. The frequency of reported occurrence of bronchitis, upper respiratory infection, and giardiasis were also statistically significantly elevated. The findings suggest an increased risk for certain respiratory, gastrointestinal, and other diseases among residents living near farm fields on which the use of biosolids was permitted. However, further studies are needed to address the limitations cited in this study.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Health Survey of Residents Living Near Farm Fields Permitted to Receive Biosolids

Khuder

Milz

Bisesi

et al. 2007

Archives of Environmental & Occupational Health

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show abstract

“…Third, our sample may not have been large enough to allow for the detection of the effect of PDDS score. Fourth, we tested more women than men; however, it should be noted that MS is more prevalent among women [31]. Finally, some participants did not undertake the faster walking trials; however, it should be considered that missing data do not present a problem in multilevel modeling.…”

Section: 1mentioning

confidence: 99%

Prediction of oxygen uptake during walking in ambulatory persons with multiple sclerosis

2016

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Abstract-People with multiple sclerosis (MS) have an increased rate of gross oxygen uptake (gross-VO 2 ) during treadmill walking, and their gross-VO 2 may further vary with walking impairment. This study attempted to develop an equation for predicting gross-VO 2 from walking speed and an index of walking impairment in persons with MS and examine its accuracy. Gross-VO 2 was measured with open-circuit spirometry in 43 persons with MS (47 +/-9 yr; 38 women) during five treadmill walking trials, each lasting 6 min, at 2.0, 2.5, 3.0, 3.5, and 4.0 mph (0.89, 1.12, 1.34, 1.56, and 1.79 m/s). The 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and the single-item Patient Determined Disease Steps scale (PDDS) provided indices of walking impairment. Multilevel modeling with random intercepts and slopes showed significant effects of speed and MSWS-12 on gross-VO 2 (p  0.014; R 2 = 0.70). PDDS was not a significant predictor. Gross-VO 2 estimated by the regression equation did not differ from actual gross-VO 2 across speeds. Mean absolute prediction error across speeds was 9.1%. The Bland-Altman plot indicated zero mean difference between actual and predicted gross-VO 2 with modest 95% confidence intervals. Therefore, speed and MSWS-12 score are jointly highly predictive of gross-VO 2 during treadmill walking in persons with MS.

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“…This is particularly the case for a condition like multiple sclerosis (MS). This disease is not routinely measured through existing surveillance programs and its causes are not well understood (Noonan et al, 2002). When scientific and resource issues make it impossible to meet community expectations, investigators need to invest the time necessary to help residents develop realistic expectations for a study and its objectives.…”

Section: Confronting Practical Limitationsmentioning

confidence: 99%

Communicating results to community residents: Lessons from recent ATSDR health investigations

White

Berger-Frank²,

Campagna³

et al. 2004

J Expo Sci Environ Epidemiol

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Health Investigations Branch, Division of Health Studies, Agency for Toxic Substances and Disease Registry, USA As a public health agency within the US Department of Health and Human Services, the Agency for Toxic Substances and Disease Registry (ATSDR) is responsible for implementing the health-related provisions of the Superfund Act. Much of its work is carried out to address health concerns in communities near sources of environmental contamination, usually in consultation with other local, state, and federal agencies. Over the last decade, ATSDR has considered, supported or conducted health investigations in a variety of different communities across the country. Communication with community residents has been an integral part of the process in all of these activities. The approach to communicating results needs to begin early by developing relationships and clarifying expectations, and it needs to remain flexible. Through examples taken from specific situations, we illustrate many of the lessons we have gained from trying to apply the principles of good community involvement to the design and conduct of health investigations and to the communication of study results.

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Prevalence estimates for MS in the United States and evidence of an increasing trend for women

Cited by 185 publications

References 15 publications

Health Survey of Residents Living Near Farm Fields Permitted to Receive Biosolids

Health Survey of Residents Living Near Farm Fields Permitted to Receive Biosolids

Prediction of oxygen uptake during walking in ambulatory persons with multiple sclerosis

Communicating results to community residents: Lessons from recent ATSDR health investigations

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