Prevalence, Distribution, and Impact of Mild Cognitive Impairment in Latin America, China, and India: A 10/66 Population-Based Study

Sosa, Ana Luisa; Albanese, Emiliano; Stephan, Blossom C M; Dewey, Michael; Acosta, Daisy; Ferri, Cleusa P.; Guerra, Mariella; Huang, Yueqin; Jacob, K. S.; Jiménez‐Velázquez, Ivonne Z.; Rodriguez, Juan J. Llibre; Salas, Aquiles; Williams, Joseph; Acosta, Isaac; González-Viruet, Maribella; Hernández, Milagros A. Guerra; Li, Shuran; Prince, Martin; Stewart, Robert

doi:10.1371/journal.pmed.1001170

Cited by 171 publications

(181 citation statements)

References 67 publications

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“…Declines in physical and cognitive function have been independently recognized as risks for disability [37][38][39]. Hence, it is plausible that the combination of cognitive and physical impairments could further increase the risk for becoming disabled.…”

Section: Discussionmentioning

confidence: 99%

Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability

Doi

Shimada

Makizako

et al. 2017

JAD

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Abstract.Background: It is important to examine the etiology of motoric cognitive risk syndrome (MCR) and its association with dementia and disability to obtain biological insights and to develop preventive strategies. Objective: This study aimed to examine the association of MCR with incidence of dementia and disability in a Japanese community-dwelling sample of older adults. Methods: Participants were 4,235 older adults (50% women, mean age: 72.0 years). MCR was diagnosed at baseline using established criteria in non-demented seniors with self-reported cognitive complaints and slow gait. Incident cases of dementia were identified from insurance data monthly. Disability was regarded as certification by long-term care insurance. Results: At baseline, 265 participants (6.3%) met criteria for MCR. During follow-up (mean duration: 29 months), there were 138 incident cases of dementia (3.3%) and 207 incident cases of disability (4.9%). Cox-proportional hazards models, adjusted for demographical data, lifestyle, and medical conditions, showed that presence of MCR at baseline was a major risk factor for developing dementia (HR 2.49, 95%CI 1.52-4.10, p < 0.001). MCR also predicted risk for disability (HR 1.69, 95%CI 1.08-2.02, p < 0.001). Conclusions: MCR is helpful in the short-term prediction of risk for dementia and disability in the elderly Japanese population. Identification of seniors with MCR is recommended for early detection and instituting preventive measures for reducing the risk of dementia and disability.

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Section: Discussionmentioning

confidence: 99%

Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability

Doi

Shimada

Makizako

et al. 2017

JAD

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“…But when latin american countries were compared, the results were more homogenous. In Mexico, the prevalence of MCI was 2.8%, with a modest association with male sex and less physical activity, but not with age or poor education 29 .…”

Section: Discussionmentioning

confidence: 89%

Clinical and Demographic Predictors of Conversion to Dementia in Mexican Elderly with Mild Cognitive Impairment

Aguilar-Navarro

Mimenza-Alvarado

Ávila-Fuñes

et al. 2017

RIC

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“…The associations between lower cognitive function scores and disability in late life were not attenuated after adjusting for chronic non‐communicable disorders. Our finding is similar to the observation by the 10/66 Dementia Research Group that dementia and amnesic mild cognitive impairment independently predict disability in late life (Sosa et al ., 2012). Unlike the previous 10/66 research reports from India that examined the impact of diagnostic categories of cognitive impairment (amnesic mild cognitive impairment and dementia) on disability, this study examined cognitive function as a continuous variable.…”

Section: Discussionmentioning

confidence: 99%

Cognitive function and disability in late life: an ecological validation of the 10/66 battery of cognitive tests among community‐dwelling older adults in South India

Krishna

Beulah

Jones

et al. 2015

Int J Geriat Psychiatry

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BackgroundThe 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population‐based studies in low‐income and middle‐income countries including India.AimsThis study examined the association between individual domains of the 10/66 battery of cognitive tests and ‘disability’ and ‘functional impairment’ in community‐dwelling older adults in South India.MethodsOne hundred twenty‐nine adults aged 60–90 years residing in Karunapura, in the city of Mysore, were interviewed in their own homes. Cognitive functioning was measured by administering the 10/66 battery of cognitive tests that composes of Community Screening Instrument for Dementia (CSI'D' COGSCORE), verbal fluency (VF) and word list memory recall (WLMR). A reliable informant was interviewed to ascertain if the subject's cognitive problems have resulted in functional impairment. Disability was measured by WHO Disability Schedule‐II (DAS).ResultsThe women had significantly lower CSI'D' COGSCORE score when compared with men (p = 0.002). The presence of ‘functional impairment’ resulting from cognitive decline was significantly associated with lower scores on VF (p = 0.03), WLMR (p = 0.03) and CSI'D' COGSCOREs (p < 0.01). There was a significant inverse association between WHO DAS II score and WLMR (p = 0.004), VF (0.006) and CSI'D' COGSCORE scores (p ≤ 0.001) even after adjusting for self‐reported ischaemic heart disease, stroke, chronic obstructive airway disease, hypertension and diabetes.ConclusionsLower scores on individual domains of the 10/66 battery of cognitive tests are associated with higher levels of disability and functional impairment in community‐dwelling older adults. These culture and education fair tests are suitable for use in population‐based research in India. Copyright © 2015 John Wiley & Sons, Ltd.

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Prevalence, Distribution, and Impact of Mild Cognitive Impairment in Latin America, China, and India: A 10/66 Population-Based Study

Abstract: A set of cross-sectional surveys carried out in Cuba, Dominican Republic, Peru, Mexico, Venezuela, Puerto Rico, China, and India reveal the prevalence and between-country variation in mild cognitive impairment at a population level.

Cited by 171 publications

References 67 publications

Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability

Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability

Clinical and Demographic Predictors of Conversion to Dementia in Mexican Elderly with Mild Cognitive Impairment

Cognitive function and disability in late life: an ecological validation of the 10/66 battery of cognitive tests among community‐dwelling older adults in South India

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