Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK

Jolliffe, David A.; Kilpin, Kate; MacLaughlin, Beverley; Greiller, Claire; Hooper, Richard; Barnes, Neil; Timms, Philip; Rajakulasingam, Raj K; Bhowmik, Angshu; Choudhury, Aklak; Simcock, David E; Hyppönen, Elina; Corrigan, Christopher; Griffiths, Christopher J.; Martineau, Adrian R.

doi:10.1016/j.jsbmb.2016.11.004

Cited by 18 publications

(11 citation statements)

References 29 publications

(10 reference statements)

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“…Vitamin D reportedly reduces eosinophilic airway inflammation in murine lung tissue [ 40 ] and sputum from asthma patients [ 41 ]. Even though the literature reports a positive correlation between sputum and serum eosinophilia [ 42 ], several articles mention that vitamin D supplements and serum 25-OH-VitD status do not seem to significantly influence serum eosinophils [ 18 , 43 ], similar to the finding reported in the current study. Our results can be explained by the fact that the link between the eosinophil count and serum 25-OH-VitD was only evaluated once, at the moment that the patient was included in the study, therefore offering only a snapshot of the inflammation, whereas monitoring the dynamics of the serum levels of both might yield a more accurate reflection of the evolution of inflammation during oral vitamin D 3 therapy [ 29 ].…”

Section: Discussionsupporting

confidence: 87%

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Adam-Bonci

Cherecheş-Panţa

Bonci

et al. 2020

IJERPH

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Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D3 intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month (p = 0.02). Even under seasonal oral vitamin D3 supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D3 status in regard to asthma, especially in symptomatic patients.

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Section: Discussionsupporting

confidence: 87%

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Adam-Bonci

Cherecheş-Panţa

Bonci

et al. 2020

IJERPH

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“…These studies suggest that there is no association between vitamin D status and markers of asthma severity and control which contrasts with results seen in children. 58 Similarly in a Danish study, no significant associations where found between serum vitamin D levels and the prevalence or incidence of atopy, asthma or wheezing in adults. 59 …”

Section: Adultsmentioning

confidence: 87%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

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Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations and overall worse outcomes in patients with asthma. Given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Several studies have found that low serum levels of vitamin D (< 20 ng/ml) are associated with increased exacerbations, increased airway inflammation, decreased lung function and poor prognosis in asthmatic patients. Results from the in vitro and in vivo studies in animals and human have suggested that supplementation with vitamin D can ameliorate several hallmark features of asthma. However, the findings obtained from clinical trials are controversial and do not unequivocally support the beneficial role of vitamin D in asthma. Largely, interventional studies in children, pregnant women and adults have primarily found little-to-no effect of vitamin D supplementation on improved asthma symptoms, onset or progression of the disease. This could be related to the severity of the disease process and other confounding factors. Despite the conflicting data obtained from clinical trials, vitamin D deficiency does influence the inflammatory response in the airways. Further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce anti-inflammatory effects. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in bronchial asthma.

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“…Vitamin D, apart from its classical role in bone mineral homeostasis, has been receiving attention for its extraskeletal effects. Deficiency of vitamin D (serum 25OH D3 levels < 30 ng mL −1 ) has been reported to be highly prevalent across different populations and geographical locations . Apart from reduced exposure to sunshine, conditions such as chronic renal failure may lead to low levels of active vitamin D in the body .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing Myocardial Insulin Resistance

Nizami

Katare

Prabhakar

et al. 2019

Molecular Nutrition Food Res

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Scope Cause‐effect relationship between vitamin D deficiency and cardiometabolic abnormalities remains undefined. The aim is to investigate the role of vitamin D deficiency in cardiac failure, through possible involvement in myocardial insulin signaling. Methods and results Male SD rats (n = 6) are fed a normal diet (Con), vitamin D‐deficient diet [Con(‐)], or high‐fat, high fructose diet (HFHFrD) for 20 weeks. Cardiac hypertrophy and fetal gene program are confirmed in Con(‐) group. Cardiac dysfunction is assessed by echocardiography. Elevated renin, TGF‐β and collagen‐1α mRNAs, p‐ERK1/2, and perivascular fibrosis indicate cardiac remodeling in Con(‐) group. Increased serum insulin, triglycerides, and blood pressure, and decreased glucose tolerance and HDL cholesterol are observed in Con(‐) rats. Decreased p‐Akt/Akt, GLUT4, SOD2, and catalase, and increased NF‐κB, TNF‐α, and IL‐6 are observed in Con(‐) hearts. In H9c2 cells, calcitriol attenuates palmitate‐induced insulin resistance. VDR‐silenced H9c2 cells show reduced Akt phosphorylation, GLUT4 translocation, and 2‐NBDG uptake. Findings in Con(‐) and HFHFrD groups are comparable. Conclusion Vitamin D deficiency in rats mimic high‐fat‐, high‐fructose‐induced metabolic syndrome and cardiac dysfunction. This study demonstrates that vitamin D deficiency is an independent risk factor for heart failure, at least in part, through induction of myocardial insulin resistance.

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Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK

Cited by 18 publications

References 29 publications

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing Myocardial Insulin Resistance

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