Prévalence des cancers dans la population afro-caribéenne atteinte de dermatomyosite et de syndrome des anti-synthétases : étude préliminaire au CHU de Pointe-à-Pitre, 2000–2012

Tersiguel, A.-C.; Longueville, C.; Beltan, Eric; Vincent, Thierry; Tressières, Benoît; Cordel, N.

doi:10.1016/j.annder.2014.04.112

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Interestingly, several dermatological manifestations of DM such as cutaneous necrosis, skin vasculitis or pruritus, or histological patterns such as leucocytoclastic vasculitis are reported to be associated with cancer whatever the ethnic group ( 27 , 28 ). Conversely, several features seem to protect against cancer such as Afro-Caribbean ethnicity ( 29 ).…”

Section: Dm Risk Of Cancer and Diagnostic Contribution Of Autoantibmentioning

confidence: 99%

Dermatomyositis and Immune-Mediated Necrotizing Myopathies: A Window on Autoimmunity and Cancer

2017

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Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the clinical course of myositis reflects that of cancer and the short delay between myositis and cancer onset support the notion that myositis may be an authentic paraneoplastic disorder. Thus, cancer-associated myositis raises the question of cancer as a cause rather than a consequence of autoimmunity. Among myositides, dermatomyositis and more recently, although to a lesser extent, immune-mediated necrotizing myopathies are the most documented forms associated with cancer. Interestingly, the current diagnostic approach for myositis is based on the identification of specific antibodies where each antibody determines specific clinical features and outcomes. Recent findings have shown that the autoantibodies anti-TIF1γ, anti-NXP2 and anti-HMGCR are associated with cancers in the course of myositis. Herein, we highlight the fact that the targets of these three autoantibodies involve cellular pathways that intervene in tumor promotion and we discuss the role of cancer mutations as autoimmunity triggers in adult myositis.

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Section: Dm Risk Of Cancer and Diagnostic Contribution Of Autoantibmentioning

confidence: 99%

Dermatomyositis and Immune-Mediated Necrotizing Myopathies: A Window on Autoimmunity and Cancer

2017

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“…DM is known for its clinical features that make it easily recognizable in fair‐skinned patients: violaceous to dusky rash of the eyelid margin, eyelid oedema, papules of bony prominences (hands, knees and elbows), periungual telangiectatic erythema, facial erythema, palmar violaceous macules/papules, erythema of the trunk and/or shoulders, erythema of the lateral hips, mechanic's hands, flagellate erythema, nonscarring alopecia, cutaneous necrosis and poikiloderma 1,2 . DM has been naturally described and can occur in PoC, 3–5 and our case illustrates the difficulties of such diagnosis in those patients.…”

Section: Discussionmentioning

confidence: 99%

Amyopathic anti‐TIF1‐γ antibody‐positive dermatomyositis in a young man

Kluger

2023

JEADV Clinical Practice

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Dermatomyositis (DM) is a rare idiopathic inflammatory disorder characterized by the association of typical skin and myositis. It may be associated with interstitial lung disease and/or malignancy. Diagnosis is usually easy in patients with fair skin due to very peculiar clinical features, but, among persons of colour (PoC), diagnosis can become challenging for an unexperienced eye, especially in case of lack of clinical myositis. We present the case of a young man with amyopathic DM that has evolved for 4 years before the proper diagnosis has been made. Our case highlights the pitfalls related to the clinical presentation of DM in PoC.

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“…21,22 This poor prognosis is not explained by patient wandering, leading to late diagnosis of advanced forms, nor by a high prevalence of associated cancers, a major prognostic factor in the disease, since the prevalence of paraneoplastic forms of dermatomyositis is very low in the Afro-Caribbean population. [23][24][25] This raises the question of a particularly severe disease phenotype in patients of African descent.…”

Section: Epidemiology and Prognosismentioning

confidence: 99%