Prevalence, Deaths, and Disability-Adjusted Life-Years Due to Asthma and Its Attributable Risk Factors in 204 Countries and Territories, 1990-2019

Safiri, Saeid; Carson‐Chahhoud, Kristin; Karamzad, Nahid; Sullman, Mark J.M.; Nejadghaderi, Seyed Aria; Taghizadieh, Ali; Bell, Arielle Wilder; Kolahi, Ali‐Asghar; Ansarin, Khalil; Mansournia, Mohammad Alì; Collins, Gary S.; Kaufman, Jay S.

doi:10.1016/j.chest.2021.09.042

Cited by 41 publications

(52 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These include demographic factors, such as age and sex; developmental factors, such as preterm birth; mode of delivery and history of infections; socioeconomic status-related factors, such as agricultural subsistence, income and daycare enrollment; dietary factors and medications; and, last but not least, inhaled exposures, such as tobacco, air pollution and air allergens [ 9 ]. The latest evidence from Global Burden of Disease placed smoking second among the leading risk factors for DALYs attributed to asthma [ 2 ].…”

Section: Smoking As a Risk Factor Of Asthmamentioning

confidence: 99%

“…Asthma is a common chronic airways disease characterized by variable expiratory airflow obstruction [ 1 ]. The latest Global Burden of Disease estimated the global prevalence of asthma at 262 million cases (95% UI, 224–309), based on available evidence from 2019 [ 2 ]. The trademarks of asthma are airway inflammation and airway hyperresponsiveness, manifesting with varying degrees of dyspnea, wheezing, cough and/or chest tightness.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Asthma and Tobacco Smoking

Bellou

Gogali

Κostikas

2022

JPM

View full text Add to dashboard Cite

Asthma is a prevalent chronic pulmonary condition with significant morbidity and mortality. Tobacco smoking is implicated in asthma pathophysiology, diagnosis, prognosis and treatment. Smokers display increased prevalence and incidence of asthma, but a causal association cannot be claimed using existing evidence. Second-hand smoking and passive exposure to tobacco in utero and early life have also been linked with asthma development. Currently, approximately one-fourth of asthma patients are smokers. Regular smokers with asthma might display accelerated lung function decline and non-reversible airflow limitation, making their distinction from chronic obstructive pulmonary disease patients challenging. Asthma patients who smoke typically have uncontrolled disease, as shown by increased symptoms, more exacerbations and impaired quality of life. On the other hand, smoking cessation improves lung function and asthma severity. Thus, asthma patients and their caregivers should be actively questioned about their smoking status at each medical encounter, and smoking cessation ought to be strongly encouraged both for patients with asthma and their close contacts. Smokers with asthma should be provided with comprehensive smoking cessation interventions on top of other anti-asthma medications.

show abstract

Section: Smoking As a Risk Factor Of Asthmamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Asthma and Tobacco Smoking

Bellou

Gogali

Κostikas

2022

JPM

View full text Add to dashboard Cite

show abstract

“…The model assumed that patients in each state are at risk of death. However, as only three patients died in TRIMARAN and two in TRIGGER, and asthma-related deaths are rare (and getting rarer) [18], the model included all-cause mortality (without excess asthma-related mortality), based on life tables from the UK Office for National Statistics [19].…”

Section: Model Transition Probabilitiesmentioning

confidence: 99%

Cost-effectiveness of single-inhaler extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium in patients with uncontrolled asthma in England

Orlović¹,

Magni²,

Lukyanov³

et al. 2022

Respiratory Medicine

View full text Add to dashboard Cite

“…While asthma prevalence is greater in male children than in females, it reverses at age 13 (which is mostly the onset of puberty) and continues to about age 65–70 years of adulthood ( 2 ). In 2019, the global prevalence of asthma was 136 per million in females, and 127 per million in males ( 3 ). In addition, females have been consistently shown to have a higher death rate due to asthma than males ( 1 , 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors

Ekpruke

Silveyra

2022

Front. Allergy

View full text Add to dashboard Cite

Asthma is characterized by an increase in the contraction and inflammation of airway muscles, resulting in airflow obstruction. The prevalence of asthma is lower in females than in males until the start of puberty, and higher in adult women than men. This sex disparity and switch at the onset of puberty has been an object of debate among many researchers. Hence, in this review, we have summarized these observations to pinpoint areas needing more research work and to provide better sex-specific diagnosis and management of asthma. While some researchers have attributed it to the anatomical and physiological differences in the male and female respiratory systems, the influences of hormonal interplay after puberty have also been stressed. Other hormones such as leptin have been linked to the sex differences in asthma in both obese and non-obese patients. Recently, many scientists have also demonstrated the influence of the sex-specific genomic framework as a key player, and others have linked it to environmental, social lifestyle, and occupational exposures. The majority of studies concluded that adult men are less susceptible to developing asthma than women and that women display more severe forms of the disease. Therefore, the understanding of the roles played by sex- and gender-specific factors, and the biological mechanisms involved will help develop novel and more accurate diagnostic and therapeutic plans for sex-specific asthma management.

show abstract

Prevalence, Deaths, and Disability-Adjusted Life-Years Due to Asthma and Its Attributable Risk Factors in 204 Countries and Territories, 1990-2019

Cited by 41 publications

References 35 publications

Asthma and Tobacco Smoking

Asthma and Tobacco Smoking

Cost-effectiveness of single-inhaler extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium in patients with uncontrolled asthma in England

Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors

Contact Info

Product

Resources

About