Prévalence de l’infection par le virus de l’hépatite-C au Maroc et évaluation des tests sérologiques de dépistage pour la prédiction de la virémie

Benouda, A.; Boujdiya, Z.; Ahid, Samir; Abouqal, Rédouane; Adnaoui, M.

doi:10.1016/j.patbio.2008.07.006

Cited by 33 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar picture was also found in Tunisia and Morocco, where the rates ranged from 1.7 to 2.9%, with higher rates in some regions [35,36]. Hepatitis C virus screening and surveillance is minimal at the national level in these countries.…”

Section: Discussionsupporting

confidence: 61%

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Daw

El-Bouzedi

2014

BMC Infect Dis

View full text Add to dashboard Cite

BackgroundLibya is one of the largest countries in Africa and has the longest coast in the Mediterranean basin facing southern Europe. High rates of prevalence of viral hepatitis have been observed in various regions in Africa, but the prevalence in Libya is not well documented. We report on a large-scale nationwide study that evaluated the epidemiology of hepatitis B and hepatitis C in Libya and assessed the risk factors involved.MethodsA cross-sectional study was carried out in 2008 on 65,761 individuals all over Libya. The country was divided into 12 regions according to the population density and sampling within each region was carried out under the supervision of the National Centre for Prevention of Infectious Diseases. Serum samples were collected from both males and females of all ages in both urban and rural areas and tested for HBsAg for hepatitis B and anti-HCV antibody for hepatitis C. Prevalence rates were determined in regions and in different groups and correlated with different demographic and risk factors involved in the spread of these viruses.ResultsThe prevalence of hepatitis B and hepatitis C viruses varied regionally across the country. The overall prevalence of hepatitis B was 2.2% (95% CI 2.1%-2.3%) and was higher among males than females (1.4:1.0). Hepatitis C virus (HCV) prevalence was 1.2% (95% CI 1.1-1.3) and it increased gradually after the age of 30 years (0.7-0.9% for < 30 years; 3.6% for ≥ 60 years). Prevalence of HBsAg was 0.8-0.9% below the age of 10 years, and higher but similar in older age groups (2.3-2.7%). There was an association between literacy and prevalence of hepatitis, particularly for HCV. Hospital admission, surgical operation, blood transfusion, and intravenous drug use were the main risk factors, and they were associated independently with a higher prevalence rate of viral hepatitis.ConclusionsLibya may be considered an area of low-intermediate endemicity for hepatitis B virus infection, with lower rates in young age groups, and an area of low endemicity for hepatitis C. The prevalence of hepatitis B and C across Libya is not homogeneous, with indications of the effect of the higher rates in some neighbouring countries. Libya should adopt full coverage national plans and guidelines to face the future consequences of viral hepatitis, particularly hepatitis C virus.

show abstract

Section: Discussionsupporting

confidence: 61%

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Daw

El-Bouzedi

2014

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…Closer to home, the overall prevalence of HCV in the general Moroccan population is lower and classified as ‘intermediate’, currently estimated at 1.58% and 1.93% (Baha et al; Benouda et al) [9,10]. We note a discrepancy with the reported prevalence rate from the previous decade, which was estimated to be 7.7% in patients hospitalized for various pathologies (Cacoub et al) [11].…”

Section: Introductioncontrasting

confidence: 58%

“…While several published Moroccan studies exist in the scientific literature on hemodialysis, haemophiliacs and chronic HCV-infected patients (Sekkak et al; Benouda et al; Benani et al; Benjelloun et al) [10,24-26], the IDU group in the Maghreb region has remained a largely under-studied cohort to date. Due to the paucity of published data, this study sought to characterize this elusive and high-risk group, as well as to elucidate key difference between it and other chronically HCV-infected patients in Morocco.…”

Section: Discussionmentioning

confidence: 99%

“…Age and seropositive status were shown to be positively correlated (Baha et al; Benouda et al; Mathei et al) [9,10,30], in that older subjects (as a group) were more likely to be seropositive as compared to younger subjects ( n =132). Due to our sufficient sub-sample size and wide range of ages, we were able to repeat the analysis by binning our IDU cohort into 7 age groups and calculating the average seropositivity for each group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The “hidden” epidemic: a snapshot of Moroccan intravenous drug users

Trimbitas

Serghini²,

Lazaar

et al. 2014

Virol J

View full text Add to dashboard Cite

BackgroundHepatitis C virus is a persistent epidemiological problem, with an estimated 170 million individuals infected worldwide, and the leading cause of asymptomatic chronic infection, liver cirrhosis and hepatocellular carcinoma. Injection drug users (IDUs) have the highest seroprevalence as compared to chronic hemodialysis and transfusion patients, and this cohort remains the most under-studied high-risk group in North Africa to date. This study first sought to characterize the demographic, epidemiological, and genotypic profile of a total sample size of 211 chronically-infected IDUs living in the Tangier region of Northern Morocco, and secondly to contrast this to other chronically-infected patients, in order to uncover possible discrepancies.ResultsThe general ‘profile’ of local IDUs marks a stark contrast to chronically-infected HCV Moroccan patients, other African countries, and neighboring European countries. The majority of Moroccan drug users were found to be middle-aged and celibate. A relatively high seroprevalence was found among drug users (60%), and this increased with age. The majority of drug users shared their needles and this hold implications for transmission, as seropositive status was significantly different between those users that shared vs. those that did not share their needles. In addition, IDUs exhibited genotypes 1a and 3a predominantly, as compared to the predominant 1b and 2a/2c genotypes found in chronically HCV-infected patients. The IDU genotypic profile closely matches the one in other European countries (Portugal, Spain, France, and Italy), which are invariably speculated as the potential source of currently-circulating genotypes in Moroccan IDUs.ConclusionThese findings have implications for disease prevention, transmission and treatment, as this distinct IDU subgroup cannot be collectively pooled along with other HCV-positive high-risk groups. Local government, practitioners, and health institutions should take this into account when treating, prescribing antiviral therapy, and designing preventative public health campaigns.

show abstract

“…HCV prevalence rate in Morocco is estimated to be 1.93 % 88. However, higher HCV prevalence rates reaching 35.1 and 42.4% are detected among special populations such as patients undergoing haemodialysis and haemophiliacs respectively 89,90,91…”

Section: Hepatitis C Virus (Hcv) Infectionmentioning

confidence: 99%

Viral hepatitis A to E in South Mediterranean Countries

Kamal¹,

Mahmoud²,

Hafez³

et al. 2010

Medit J Hematol Infect Dis

View full text Add to dashboard Cite

Viral hepatitis represents an important health problem in the South Mediterranean countries, Egypt, Libya, Tunisia, Algeria and Morocco. Emerging natural history and epidemiological information reveal differences in the overall epidemiology, risk factors and modes of transmission of viral hepatitis A, B, C, D, E infections in the South Mediterranean region. The differences in the in incidence and prevalence of viral hepatitis across North African countries is attributed to variations in health care and sanitation standards, risk factors and immunization strategies. The active continuous population movement through travel, tourism and migration from and to the South Mediterranean countries contribute to the spread of infections due to hepatitis viruses across borders leading to outbreaks and emergence of new patterns of infection or introduction of uncommon genotypes in other countries, particularly in Europe.

show abstract

Prévalence de l’infection par le virus de l’hépatite-C au Maroc et évaluation des tests sérologiques de dépistage pour la prédiction de la virémie

Cited by 33 publications

References 10 publications

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

The “hidden” epidemic: a snapshot of Moroccan intravenous drug users

Viral hepatitis A to E in South Mediterranean Countries

Contact Info

Product

Resources

About