Prévalence de l’asthme chez l’adulte en France, données de la cohorte Constances

Delmas, Marie-Christine; Bénézet, L.; Ribet, Céline; Iwatsubo, Y.; Provost, D.; Varraso, Raphäelle; Zins, Marie; Leynaert, Bénédicte; Nadif, Rachel; Roche, Nicolás

doi:10.1016/j.rmr.2021.05.007

Cited by 14 publications

(8 citation statements)

References 31 publications

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“…We observed a crude prevalence of ever asthma in adults of 13·5%, which is very close to the weighted prevalence of 14% recently reported in CONSTANCES 4 and that of 12·8% reported in the ASTHMAPOP survey. 2 The prevalence of current asthma was higher in our study than in ASTHMAPOP (9·5 vs. 6·4% respectively), likely explained by a difference in the current asthma definition.…”

Section: Discussionsupporting

confidence: 87%

“…Asthma is the second most common chronic respiratory disease in the world, 1 affecting around one in ten adults in France. 2 , 3 , 4 Although its common clinical manifestations are wheezing, shortness of breath, tightness and cough, asthma is a complex and very heterogeneous disease that encompasses various phenotypes. 5 Better understanding these phenotypes, in particular their specific clinical presentation and the underlying type of inflammation, would enhance our understanding and management of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort

et al. 2022

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort

et al. 2022

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“…Reports on asthma prevalence and disease characterization have revealed wide variations within and between countries [3][4][5][6][7]; thus, assessing the burden of asthma can be challenging. In France, the prevalence of current asthma in 2018 was estimated between 6.4 and 9.3% depending on the definition and the study [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the stability of asthma prevalence in France since 2006 [10], data on its economic burden are rare and old. The CONSTANCES cohort, which is a large sample of the general French adult population, offers the unique opportunity to better understand the economic and clinical burden of asthma in patients living with the disease.…”

Section: Introductionmentioning

confidence: 99%

Asthma Burden According to Treatment Steps in the French Population-Based Cohort CONSTANCES

et al. 2022

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“…A pooled analysis of national and international COPD surveys estimated that 81% of COPD patients were undiagnosed [ 3 ]. In France, the most recent estimate of the prevalence of current asthma in adults varies from 6 to 9% according to the definition [ 4 ]. In the early 2000s, the prevalence of airflow limitation (based on pre-bronchodilator tests) was estimated at 7.5% among non-asthmatic individuals aged 45 years and over [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort

et al. 2021

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Background The burden of undiagnosed obstructive lung disease (OLD) (mainly asthma and chronic obstructive pulmonary disease) is not fully established, and targets for corrective action are yet to be identified. We assessed the underdiagnosis of OLD and its determinants in France. Methods CONSTANCES is a French population-based cohort of adults aged 18–69 years at inception. We analysed data collected at inclusion in 2013–2014. Undiagnosed OLD was defined as spirometry-confirmed airflow limitation (FEV1/FVC < lower limit of normal) without prior diagnosis of asthma, chronic obstructive pulmonary disease, or bronchiectasis. Multivariate analysis was performed with weighted robust Poisson regression models to estimate the adjusted prevalence ratios (aPR) of undiagnosed OLD. Results Spirometry results were available for 19,398 participants. The prevalence of airflow limitation was 4.6%. Overall, 64.4% of adults with airflow limitation did not report a previous diagnosis of OLD. Individuals with high cumulative tobacco consumption (≥ 10 pack-years) (aPR: 1.72 [1.28–2.32]), without respiratory symptoms (aPR: 1.51 [1.28–1.78]), and with preserved lung function (aPR: 1.21 [1.04–1.41] for a 10-point increase in FEV1% predicted) had a higher risk of being undiagnosed. Half of symptomatic individuals with airflow limitation (45% of those with moderate to severe airflow limitation) were undiagnosed with OLD. Conclusion Underdiagnosis of OLD is very common among French adults, even in patients with respiratory symptoms. Efforts should be made in France to raise awareness about OLD in the general population, improve the detection of respiratory symptoms, and increase the use of spirometry among primary care professionals.

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Prévalence de l’asthme chez l’adulte en France, données de la cohorte Constances

Cited by 14 publications

References 31 publications

Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort

Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort

Asthma Burden According to Treatment Steps in the French Population-Based Cohort CONSTANCES

Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort

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