Prevalence, correlations, and impact of sleep disturbance in Chinese patients with primary pituitary adenomas

Abstract

Purpose Sleep disorders are prevalent among patients with pituitary adenoma (PA) and may lead to disease aggravation and decreased health-related quality of life (HRQoL). Relatively scarce information is available on sleep disturbance in primary PA patients in China. Therefore, this study aims to evaluate the sleeping quality in Chinese primary PA patients and the prevalence, correlates, and impact of sleep disturbance. Methods A total of 203 primary PA patients were involved in this cross-sectional study. A series of questionnaires (Pittsburgh Sleep Quality Index (PSQI), MD Anderson Symptom Inventory Brain Tumor for clinical manifestations (MDASI-BT), Hospital Anxiety and Depression Scale (HADS), Multidimensional Fatigue Inventory (MFI-20), and the Short Form 36 health survey (SF-36)) were applied. Independent samples t tests, Mann-Whitney U test, Chi-square analysis, and logistic regression were used to analyze these data. Results Our results found that the prevalence of sleep disturbance was 47.8% in primary PA patients. The significant differences were found on the place of residence, alcohol use, depression, anxiety, fatigue, somatic symptom scores and counts, among poor sleepers and good sleepers. Binary logistic regression indicated that fatigue and alcohol use were independently associated with sleep disturbance of primary PA patients. Meanwhile, HRQL of sleep poor patients is clearly lower than those with good sleep. Conclusions Primary PA patients in China suffered from sleep disturbance. The results emphasize the importance of fatigue and alcohol use in the sleep disturbance of PA patients. Medical personnel should pay more attention to PA patients with sleep disturbance before the initial diagnosis and preparation for surgery in order to take effective measures early to improve sleep disturbance, with the ultimate goal to improve their QoL.

Fatigue and Its Contributing Factors in Chinese Patients with Primary Pituitary Adenomas

“…The part of this manuscript was published as a preprint in https://www.researchsquare.com/article/rs-1702253/v1 [ 62 ]. In summary, this research reveals a high prevalence of fatigue in PA patients who are newly diagnosed and preparing for surgical procedures, providing useful knowledge and insights into fatigue and QoL.…”